Methotrexate analogs. 15. A methotrexate analogue designed for active-site-directed irreversible inactivation of dihydrofolate reductase

1982 ◽  
Vol 25 (8) ◽  
pp. 960-964 ◽  
Author(s):  
A. Rosowsky ◽  
J. E. Wright ◽  
C. Ginty ◽  
J. Uren
Keyword(s):  
Dihydrofolate Reductase ◽  
Active Site

scholarly journals Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase

2011 ◽  
Vol 176 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Vivian Cody ◽  
Jim Pace ◽  
Jennifer Piraino ◽  
Sherry F. Queener
Keyword(s):  
Binding Site ◽  
Dihydrofolate Reductase ◽  
Active Site ◽  
Crystallographic Analysis ◽  
Human Dihydrofolate Reductase

scholarly journals Correlations of Inhibitor Kinetics forPneumocystis jiroveciiand Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes†‡

Biochemistry ◽  
2009 ◽  
Vol 48 (8) ◽  
pp. 1702-1711 ◽  
Author(s):  
Vivian Cody ◽  
Jim Pace ◽  
Jennifer Makin ◽  
Jennifer Piraino ◽  
Sherry F. Queener ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Active Site ◽  
Structural Data ◽  
Mutant Enzyme ◽  
Human Dihydrofolate Reductase ◽  
Enzyme Complexes ◽  
Inhibitor Kinetics

Role of the Active-Site Carboxylate in Dihydrofolate Reductase: Kinetic and Spectroscopic Studies of the Aspartate 26 .fwdarw. Asparagine Mutant of the Lactobacillus casei Enzyme

Biochemistry ◽  
1995 ◽  
Vol 34 (9) ◽  
pp. 2872-2882 ◽  
Author(s):  
J. Basran ◽  
M. G. Casarotto ◽  
I. L. Barsukov ◽  
G. C. K. Roberts
Keyword(s):  
Dihydrofolate Reductase ◽  
Active Site ◽  
Lactobacillus Casei ◽  
Spectroscopic Studies

ACTIVE-SITE DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE

1971 ◽  
Vol 186 (1 Folate Antago) ◽  
pp. 214-226 ◽  
Author(s):  
B. R. Baker
Keyword(s):  
Dihydrofolate Reductase ◽  
Active Site ◽  
Irreversible Inhibitors

Free Energy Simulations of Active-Site Mutants of Dihydrofolate Reductase

2014 ◽  
Vol 119 (3) ◽  
pp. 906-916 ◽  
Author(s):  
Dvir Doron ◽  
Vanja Stojković ◽  
Lokesh Gakhar ◽  
Alexandra Vardi-Kilshtain ◽  
Amnon Kohen ◽  
...  
Keyword(s):  
Free Energy ◽  
Dihydrofolate Reductase ◽  
Active Site ◽  
Energy Simulations ◽  
Active Site Mutants

Solvent environments significantly affect the enzymatic function of Escherichia coli dihydrofolate reductase: Comparison of wild-type protein and active-site mutant D27E

2013 ◽  
Vol 1834 (12) ◽  
pp. 2782-2794 ◽  
Author(s):  
Eiji Ohmae ◽  
Yurina Miyashita ◽  
Shin-ichi Tate ◽  
Kunihiko Gekko ◽  
Soichiro Kitazawa ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Dihydrofolate Reductase ◽  
Active Site ◽  
Wild Type ◽  
Enzymatic Function ◽  
Type Protein ◽  
Wild Type Protein

Atomic Scale Determination of Enzyme Flexibility and Active Site Stability through Static Modes: Case of Dihydrofolate Reductase

2011 ◽  
Vol 115 (7) ◽  
pp. 1616-1622 ◽  
Author(s):  
Marie Brut ◽  
Alain Estève ◽  
Georges Landa ◽  
Guillaume Renvez ◽  
Mehdi Djafari Rouhani ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Active Site ◽  
Atomic Scale
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