Peptide-Based Inhibitors of the Hepatitis C Virus NS3 Protease:  Structure−Activity Relationship at theC-Terminal Position

2004 ◽  
Vol 47 (10) ◽  
pp. 2511-2522 ◽  
Author(s):  
Jean Rancourt ◽  
Dale R. Cameron ◽  
Vida Gorys ◽  
Daniel Lamarre ◽  
Martin Poirier ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Terminal Position ◽  
Structure Activity ◽  
Ns3 Protease

Discovery and Structure−Activity Relationship of P1−P3Ketoamide Derived Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease

2009 ◽  
Vol 52 (2) ◽  
pp. 336-346 ◽  
Author(s):  
Srikanth Venkatraman ◽  
Francisco Velazquez ◽  
Wanli Wu ◽  
Melissa Blackman ◽  
Kevin X. Chen ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of ◽  
Ns3 Protease

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

2004 ◽  
Vol 47 (9) ◽  
pp. 2283-2295 ◽  
Author(s):  
Anne B. Eldrup ◽  
Charles R. Allerson ◽  
C. Frank Bennett ◽  
Sanjib Bera ◽  
Balkrishen Bhat ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Hepatitis C Virus Rna ◽  
Rna Dependent Rna Polymerase ◽  
Structure Activity ◽  
Virus Rna ◽  
Relationship Of

Imidazopyridazine Hepatitis C Virus Polymerase Inhibitors. Structure–Activity Relationship Studies and the Discovery of a Novel, Traceless Prodrug Mechanism

2013 ◽  
Vol 57 (5) ◽  
pp. 1964-1975 ◽  
Author(s):  
Martin Leivers ◽  
John F. Miller ◽  
Stephanie A. Chan ◽  
Ryan Lauchli ◽  
Sebastian Liehr ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Polymerase Inhibitors ◽  
Structure Activity

Large-scale structure-activity relationship study of hepatitis C virus NS5B polymerase inhibition using SMILES-based descriptors

2015 ◽  
Vol 19 (4) ◽  
pp. 955-964 ◽  
Author(s):  
Apilak Worachartcheewan ◽  
Virapong Prachayasittikul ◽  
Alla P. Toropova ◽  
Andrey A. Toropov ◽  
Chanin Nantasenamat
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Large Scale ◽  
Large Scale Structure ◽  
Structure Activity Relationship ◽  
Scale Structure ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study ◽  
Ns5b Polymerase

scholarly journals Sulfur(vi) fluoride exchange as a key reaction for synthesizing biaryl sulfate core derivatives as potent hepatitis C virus NS5A inhibitors and their structure–activity relationship studies

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31803-31821 ◽  
Author(s):  
Youngsu You ◽  
Hee Sun Kim ◽  
Jung Woo Park ◽  
Gyochang Keum ◽  
Sung Key Jang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design And Synthesis ◽  
Structure Activity

SuFEx chemistry was utilized for the design and synthesis of potent HCV NS5A inhibitors featuring a biaryl sulfate core.

Structure−Activity Relationship of New Anti-Hepatitis C Virus Agents: Heterobicycle−Coumarin Conjugates

2009 ◽  
Vol 52 (5) ◽  
pp. 1486-1490 ◽  
Author(s):  
Johan Neyts ◽  
Erik De Clercq ◽  
Raghunath Singha ◽  
Yung Hsiung Chang ◽  
Asish R. Das ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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