Structure–activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors

Activity Relationship ◽

Sar Studies ◽

Polymerase Inhibitors ◽

Structure Activity ◽

Hcv Ns5b

Benzimidazole Derivatives Bearing Substituted Biphenyls as Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase Inhibitors: Structure−Activity Relationship Studies and Identification of a Potent and Highly Selective Inhibitor JTK-109

Journal of Medicinal Chemistry ◽

10.1021/jm060269e ◽

2006 ◽

Vol 49 (15) ◽

pp. 4721-4736 ◽

Cited By ~ 107

Author(s):

Shintaro Hirashima ◽

Takayoshi Suzuki ◽

Tomio Ishida ◽

Satoru Noji ◽

Shinji Yata ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Rna Polymerase ◽

Selective Inhibitor ◽

Activity Relationship ◽

Benzimidazole Derivatives ◽

Polymerase Inhibitors ◽

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

Journal of Medicinal Chemistry ◽

10.1021/jm030424e ◽

2004 ◽

Vol 47 (9) ◽

pp. 2283-2295 ◽

Cited By ~ 153

Author(s):

Anne B. Eldrup ◽

Charles R. Allerson ◽

C. Frank Bennett ◽

Sanjib Bera ◽

Balkrishen Bhat ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Rna Polymerase ◽

Activity Relationship ◽

Hepatitis C Virus Rna ◽

Structure Activity ◽

Virus Rna ◽

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2018.04.069 ◽

2018 ◽

Vol 28 (13) ◽

pp. 2324-2327 ◽

Cited By ~ 7

Author(s):

Gang Wang ◽

Siew Pheng Lim ◽

Yen-Liang Chen ◽

Jürg Hunziker ◽

Ranga Rao ◽

...

Keyword(s):

Dengue Virus ◽

Rna Polymerase ◽

Activity Relationship ◽

Structure Activity ◽

Virus Rna ◽

StructureActivity Relationship of Polypyridyl Ruthenium(II) Complexes as DNA Intercalators, DNA Photocleavage Reagents, and DNA Topoisomerase and RNA Polymerase Inhibitors

Chemistry & Biodiversity ◽

10.1002/cbdv.201100414 ◽

2013 ◽

Vol 10 (3) ◽

pp. 367-384 ◽

Cited By ~ 14

Author(s):

Xing Chen ◽

Feng Gao ◽

Wei-Yan Yang ◽

Zhu-Xin Zhou ◽

Jin-Qiang Lin ◽

...

Keyword(s):

Rna Polymerase ◽

Activity Relationship ◽

Dna Topoisomerase ◽

Dna Photocleavage ◽

Dna Intercalators ◽

Polymerase Inhibitors ◽

Structure Activity ◽

Structure Activity Relationship of Arylidene Pyrrolo and Pyrido [2,1-b] Quinazolones as Cytotoxic Agents: Synthesis, SAR Studies, Biological Evaluation and Docking Studies

Medicinal Chemistry ◽

10.2174/1573406411309050003 ◽

2013 ◽

Vol 9 (5) ◽

pp. 642-650 ◽

Cited By ~ 3

Author(s):

Veenu Mangla ◽

Kunal Nepali ◽

Gagandip Singh ◽

Jagjeet Singh ◽

Santosh Guru ◽

...

Keyword(s):

Docking Studies ◽

Biological Evaluation ◽

Cytotoxic Agents ◽

Activity Relationship ◽

Sar Studies ◽

Structure Activity ◽

Design, synthesis and structure–activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.10.037 ◽

2015 ◽

Vol 89 ◽

pp. 21-31 ◽

Cited By ~ 26

Author(s):

Ayyiliath M. Sajith ◽

K.K. Abdul Khader ◽

Nithin Joshi ◽

Manchala Nageswar Reddy ◽

M. Syed Ali Padusha ◽

...

Keyword(s):

Cytotoxic Agents ◽

Activity Relationship ◽

Design Synthesis ◽

Sar Studies ◽

Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure–activity relationship (SAR) studies

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.01.046 ◽

2016 ◽

Vol 111 ◽

pp. 138-159 ◽

Cited By ~ 17

Author(s):

Andrea Nuzzi ◽

Annalisa Fiasella ◽

Jose Antonio Ortega ◽

Chiara Pagliuca ◽

Stefano Ponzano ◽

...

Keyword(s):

Acid Ester ◽

Activity Relationship ◽

Carbamic Acid ◽

Sar Studies ◽

Structure–activity relationship of novel low-generation dendrimers for gene delivery

Organic & Biomolecular Chemistry ◽

10.1039/c8ob01767k ◽

2018 ◽

Vol 16 (42) ◽

pp. 7833-7842 ◽

Cited By ~ 4

Author(s):

Yong-Guang Gao ◽

Xiao Lin ◽

Kai Dang ◽

Shan-Feng Jiang ◽

Ye Tian ◽

...

Keyword(s):

Gene Delivery ◽

Activity Relationship ◽

Sar Studies ◽

Structure Activity ◽

Gene Vectors ◽

Structure–activity relationship (SAR) studies are very critical to design ideal gene vectors for gene delivery.

Design, synthesis and structure–activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: Dual activity as cholinesterase and Aβ-aggregation inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.02.030 ◽

2011 ◽

Vol 19 (7) ◽

pp. 2269-2281 ◽

Cited By ~ 25

Author(s):

Tarek Mohamed ◽

Xiaobei Zhao ◽

Lila K. Habib ◽

Jerry Yang ◽

Praveen P.N. Rao

Keyword(s):

Activity Relationship ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Sar Studies ◽

Structure Activity ◽

Aβ Aggregation ◽

Aggregation Inhibitors

Synthesis and Structure–Activity Relationship (SAR) Studies of Novel Pyrazolopyridine Derivatives as Inhibitors of Enterovirus Replication

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b01863 ◽

2018 ◽

Vol 61 (4) ◽

pp. 1688-1703 ◽

Cited By ~ 16

Author(s):

Yanpeng Xing ◽

Jun Zuo ◽

Paul Krogstad ◽

Michael E. Jung

Keyword(s):

Activity Relationship ◽

Sar Studies ◽