Antitumor Activity, X-ray Crystal Structure, and DNA Binding Properties of Thiocoraline A, a Natural Bisintercalating Thiodepsipeptide

2007 ◽  
Vol 50 (14) ◽  
pp. 3322-3333 ◽  
Author(s):  
Ana Negri ◽  
Esther Marco ◽  
Verónica García-Hernández ◽  
Alberto Domingo ◽  
Antonio L. Llamas-Saiz ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Antitumor Activity ◽  
Binding Properties ◽  
X Ray ◽  
Dna Binding Properties

scholarly journals Synthesis, Crystal Structure and DNA-binding Properties of a Nickel(II) Complex with 2, 6-Bis(2-benzimidazolyl)pyridine

2010 ◽  
Vol 65 (11) ◽  
pp. 1334-1340 ◽  
Author(s):  
Huilu Wu ◽  
Xingcai Huang ◽  
Jingkun Yuan ◽  
Fan Kou ◽  
Guisheng Chen ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Fluorescence Spectra ◽  
Distorted Octahedral Geometry ◽  
Spectral Measurements ◽  
X Ray Diffraction ◽  
Binding Properties ◽  
X Ray ◽  
Distorted Octahedral ◽  
Dna Binding Properties

A novel complex of nickel(II) picrate (pic) with the V-shaped ligand 2, 6-bis(2-benzimidazolyl) pyridine (bbp) was synthesized and characterized by elemental analysis, electrical conductivity, and IR and UV/Vis spectral measurements. The crystal structure of the nickel(II) complex ([Ni(bbp)2](pic)2·2DMF) has been determined by single-crystal X-ray diffraction. The Ni(II) cation is bonded to two bbp ligands through six nitrogen atoms, resulting in a distorted octahedral geometry. The DNA-binding properties of the nickel(II) complex were investigated by electronic absorption and fluorescence spectra and by viscosity measurements. The experimental results suggest that the nickel(II) complex binds to DNA in an intercalation mode.

The X-ray structure, antitumor activity and DNA-binding properties of the new Pt bis-(imidazol-2-YL) compounds lacking a NH moiety

1995 ◽  
Vol 59 (2-3) ◽  
pp. 222 ◽  
Author(s):  
Marieke J. Bloemink ◽  
Holger Engelking ◽  
Nicole Gütschow ◽  
Stephan Karentzolpoulos ◽  
Bernt Krebs ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antitumor Activity ◽  
Binding Properties ◽  
X Ray ◽  
Dna Binding Properties

The crystal structure of a natural DNA polymerase complexed with mirror DNA

2020 ◽  
Vol 56 (14) ◽  
pp. 2186-2189
Author(s):  
Jinsu An ◽  
Jaewoo Choi ◽  
Dohyeon Hwang ◽  
Jihyun Park ◽  
Charles W. Pemble ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Dna Polymerase ◽  
Binding Properties ◽  
Dna Binding Properties

The intrinsic l-DNA binding properties of a natural DNA polymerase was discovered.

Synthesis, crystal structure and characterization of three novel copper complexes of Levofloxacin. Study of their DNA binding properties and biological activities

2014 ◽  
Vol 423 ◽  
pp. 207-218 ◽  
Author(s):  
Anastasia Galani ◽  
Eleni K. Efthimiadou ◽  
George Mitrikas ◽  
Yiannis Sanakis ◽  
Vassilis Psycharis ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Copper Complexes ◽  
Biological Activities ◽  
Binding Properties ◽  
Dna Binding Properties

Synthesis, Crystal Structure, DNA-binding Properties and Antioxidant Activities of a Lutetium(III) Complex with the Bis(N-salicylidene)-3- oxapentane-1,5-diamine Ligand

2013 ◽  
Vol 68 (3) ◽  
pp. 257-266 ◽  
Author(s):  
Guolong Pan ◽  
Yuchen Bai ◽  
Hua Wang ◽  
Jin Kong ◽  
Furong Shi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Binding Mode ◽  
Binding Properties ◽  
Metal Centers ◽  
Spectrophotometric Methods ◽  
Dna Binding Properties

A Schiff base ligand bis(N-salicylidene)-3-oxapentane-1,5-diamine (H2L) and its lutetium(III) complex, with composition Lu2(L)2(NO3)2, were synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Lu(III) complex has been determined by single-crystal X-ray diffraction. It reveals a centrosymmetric binuclear neutral entity where Lu(III) metal centers are bridged by two phenoxo oxygen atoms. The DNA-binding properties of the Lu(III) complex were investigated by spectrophotometric methods and viscosity measurements, and the results suggest that the Lu(III) complex binds to DNA via a groove binding mode. Additionally, the antioxidant activity of the Lu(III) complex was determined by the superoxide and hydroxyl radical scavenging methods in vitro, which indicate that it is a scavenger for OH· and O-· 2 radicals.

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