Design, Synthesis, and Characterization of Novel Iron Chelators:  Structure−Activity Relationships of the 2-Benzoylpyridine Thiosemicarbazone Series and Their 3-Nitrobenzoyl Analogues as Potent Antitumor Agents

Danuta S. Kalinowski;  Yu; Philip C. Sharpe; Mohammad Islam; Yi-Tyng Liao; David B. Lovejoy; Naresh Kumar; Paul V. Bernhardt; Des R. Richardson

doi:10.1021/jm070445z

Design, Synthesis, and Characterization of Novel Iron Chelators: Structure−Activity Relationships of the 2-Benzoylpyridine Thiosemicarbazone Series and Their 3-Nitrobenzoyl Analogues as Potent Antitumor Agents

Journal of Medicinal Chemistry ◽

10.1021/jm070445z ◽

2007 ◽

Vol 50 (15) ◽

pp. 3716-3729 ◽

Cited By ~ 150

Author(s):

Danuta S. Kalinowski ◽

Yu ◽

Philip C. Sharpe ◽

Mohammad Islam ◽

Yi-Tyng Liao ◽

...

Keyword(s):

Antitumor Agents ◽

Iron Chelators ◽

Synthesis And Characterization ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Design, Synthesis, and Characterization of New Iron Chelators with Anti-Proliferative Activity: Structure−Activity Relationships of Novel Thiohydrazone Analogues

Journal of Medicinal Chemistry ◽

10.1021/jm070839q ◽

2007 ◽

Vol 50 (24) ◽

pp. 6212-6225 ◽

Cited By ~ 66

Author(s):

Danuta S. Kalinowski ◽

Philip C. Sharpe ◽

Paul V. Bernhardt ◽

Des R. Richardson

Keyword(s):

Proliferative Activity ◽

Iron Chelators ◽

Synthesis And Characterization ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Activity Structure

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Design, synthesis, and structure–activity relationships of novel 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.08.019 ◽

2013 ◽

Vol 69 ◽

pp. 77-89 ◽

Cited By ~ 44

Author(s):

Qidong Tang ◽

Yanfang Zhao ◽

Xinming Du ◽

Lian'e Chong ◽

Ping Gong ◽

...

Keyword(s):

Antitumor Agents ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Potential Antitumor

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ChemInform Abstract: Antimitotic Antitumor Agents: Synthesis, Structure-Activity Relationships, and Biological Characterization of N-Aryl-N′-(2-chloroethyl)ureas as New Selective Alkylating Agents.

ChemInform ◽

10.1002/chin.200125095 ◽

2010 ◽

Vol 32 (25) ◽

pp. no-no

Author(s):

Emmanuelle Mounetou ◽

Jean Legault ◽

Jacques Lacroix ◽

Rene C-Gaudreault

Keyword(s):

Antitumor Agents ◽

Alkylating Agents ◽

Biological Characterization ◽

Structure Activity Relationships ◽

Structure Activity

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Design, synthesis and structure–activity relationships of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety as potential antitumor agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.06.068 ◽

2014 ◽

Vol 83 ◽

pp. 581-593 ◽

Cited By ~ 18

Author(s):

Shunguang Zhou ◽

Huimin Liao ◽

Chao He ◽

Yanan Dou ◽

Mingyan Jiang ◽

...

Keyword(s):

Antitumor Agents ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity ◽

Potential Antitumor

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Antitumor Agents 286. Design, Synthesis, and Structure−Activity Relationships of 3′R,4′R-Disubstituted-2′,2′-dimethyldihydropyrano[2,3-f]chromone (DSP) Analogues as Potent Chemosensitizers to Overcome Multidrug Resistance

Journal of Medicinal Chemistry ◽

10.1021/jm101249z ◽

2010 ◽

Vol 53 (24) ◽

pp. 8700-8708 ◽

Cited By ~ 20

Author(s):

Ting Zhou ◽

Qian Shi ◽

Kenneth F. Bastow ◽

Kuo-Hsiung Lee

Keyword(s):

Multidrug Resistance ◽

Antitumor Agents ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Design, Synthesis, Structure−Activity Relationships, and Biological Characterization of Novel Arylalkoxyphenylalkylamine σ Ligands as Potential Antipsychotic Drugs

Journal of Medicinal Chemistry ◽

10.1021/jm980212v ◽

1999 ◽

Vol 42 (6) ◽

pp. 1076-1087 ◽

Cited By ~ 24

Author(s):

Atsuro Nakazato ◽

Kohmei Ohta ◽

Yoshinori Sekiguchi ◽

Shigeru Okuyama ◽

Shigeyuki Chaki ◽

...

Keyword(s):

Antipsychotic Drugs ◽

Biological Characterization ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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Design, synthesis, and characterization of a model peptide having potent calcitonin-like biological activity: implications for calcitonin structure/activity

Biochemistry ◽

10.1021/bi00329a026 ◽

1985 ◽

Vol 24 (8) ◽

pp. 1971-1976 ◽

Cited By ~ 69

Author(s):

Gregory R. Moe ◽

E. T. Kaiser

Keyword(s):

Biological Activity ◽

Synthesis And Characterization ◽

Model Peptide ◽

Design Synthesis ◽

Structure Activity

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Design, synthesis, and structure–activity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.08.058 ◽

2014 ◽

Vol 86 ◽

pp. 257-269 ◽

Cited By ~ 24

Author(s):

Junjie Ma ◽

Dong Chen ◽

Kuan Lu ◽

Lihui Wang ◽

Xiaoqi Han ◽

...

Keyword(s):

Antitumor Agents ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Benzothiazole Derivatives ◽

Structure Activity

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Design, synthesis and characterization of novel chromone based-copper(ii) antitumor agents with N,N-donor ligands: comparative DNA/RNA binding profile and cytotoxicity

RSC Advances ◽

10.1039/c8ra06722h ◽

2018 ◽

Vol 8 (65) ◽

pp. 37375-37390 ◽

Cited By ~ 15

Author(s):

Farukh Arjmand ◽

Zeenat Afsan ◽

Thierry Roisnel

Keyword(s):

Anticancer Agents ◽

Rna Binding ◽

Antitumor Agents ◽

Donor Ligands ◽

Synthesis And Characterization ◽

Design Synthesis ◽

Binding Profile

New chromone-based Cu(ii) tRNA targeted complexes 1–3 as potential anticancer agents have been synthesized and thoroughly characterized.

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Design, Synthesis, and Structure–Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody–Drug Conjugates

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c01385 ◽

2020 ◽

Vol 63 (22) ◽

pp. 13913-13950

Author(s):

Naidu S. Chowdari ◽

Yong Zhang ◽

Ivar McDonald ◽

Walter Johnson ◽

David R. Langley ◽

...

Keyword(s):

Antitumor Agents ◽

Design Synthesis ◽

Antibody Drug Conjugates ◽

Structure Activity Relationships ◽

Drug Conjugates ◽

Structure Activity ◽

Antibody Drug

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