scholarly journals Design, synthesis and characterization of novel chromone based-copper(ii) antitumor agents with N,N-donor ligands: comparative DNA/RNA binding profile and cytotoxicity

RSC Advances ◽  
2018 ◽  
Vol 8 (65) ◽  
pp. 37375-37390 ◽  
Author(s):  
Farukh Arjmand ◽  
Zeenat Afsan ◽  
Thierry Roisnel
Keyword(s):  
Anticancer Agents ◽  
Rna Binding ◽  
Antitumor Agents ◽  
Donor Ligands ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Binding Profile

New chromone-based Cu(ii) tRNA targeted complexes 1–3 as potential anticancer agents have been synthesized and thoroughly characterized.

Design, synthesis, and characterization of oxadiazolopyrazine analogs with application as anticancer agents

2021 ◽  
Author(s):  
Wei‐Chia Chen ◽  
Chia‐Ling Chen ◽  
Tzu‐Ting Chang ◽  
Feng‐Chun Hsieh ◽  
Wei‐Sheng Chen ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Synthesis And Characterization ◽  
Design Synthesis

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

2012 ◽  
Vol 22 (6) ◽  
pp. 2204-2208 ◽  
Author(s):  
Aldo Bianchi ◽  
Marcello Ugazzi ◽  
Luca Ferrante ◽  
Daniele Lecis ◽  
Cinzia Scavullo ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Rational Design ◽  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Smac Mimetics ◽  
Potent Drug

scholarly journals Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5814
Author(s):  
Marina Porchia ◽  
Maura Pellei ◽  
Fabio Del Bello ◽  
Carlo Santini
Keyword(s):  
Human Body ◽  
Anticancer Agents ◽  
Antitumor Agents ◽  
Physiological Role ◽  
Zinc Complexes ◽  
Redox Activity ◽  
Donor Ligands ◽  
Design Synthesis ◽  
Biological Studies ◽  
Ligands Exchange

The search for anticancer metal-based drugs alternative to platinum derivatives could not exclude zinc derivatives due to the importance of this metal for the correct functioning of the human body. Zinc, the second most abundant trace element in the human body, is one of the most important micro-elements essential for human physiology. Its ubiquity in thousands of proteins and enzymes is related to its chemical features, in particular its lack of redox activity and its ability to support different coordination geometries and to promote fast ligands exchange. Analogously to other trace elements, the impairment of its homeostasis can lead to various diseases and in some cases can be also related to cancer development. However, in addition to its physiological role, zinc can have beneficial therapeutic and preventive effects on infectious diseases and, compared to other metal-based drugs, Zn(II) complexes generally exert lower toxicity and offer few side effects. Zinc derivatives have been proposed as antitumor agents and, among the great number of zinc coordination complexes which have been described so far, this review focuses on the design, synthesis and biological studies of zinc complexes comprising N-donor ligands and that have been reported within the last five years.

Synthesis and Characterization of Methyl-Palladium and -Platinum Complexes Supported by N,O- and N,S-Donor Ligands

2016 ◽  
Vol 2016 (6) ◽  
pp. 874-879 ◽  
Author(s):  
Daniel Ruiz Plaza ◽  
José C. Alvarado-Monzón ◽  
Gabriel A. Andreu de Riquer ◽  
Gerardo González-García ◽  
Herbert Höpfl ◽  
...  
Keyword(s):  
Platinum Complexes ◽  
Donor Ligands ◽  
Synthesis And Characterization ◽  
Palladium And Platinum Complexes

scholarly journals Design of an n-type low glass transition temperature radical polymer

2021 ◽  
Author(s):  
Teng Chi ◽  
Siddhartha Akkiraju ◽  
Zihao Liang ◽  
Ying Tan ◽  
Ho Joong Kim ◽  
...  
Keyword(s):  
Glass Transition ◽  
Transition Temperature ◽  
Glass Transition Temperature ◽  
Synthesis And Characterization ◽  
Design Synthesis

We document the design, synthesis, and characterization of the first low glass transition temperature, n-type (i.e., preferentially-reduced) radical polymer.

Design, Synthesis, and Characterization of Novel CXCR4 Antagonists Featuring Cyclic Amines

ChemMedChem ◽  
2020 ◽  
Vol 15 (13) ◽  
pp. 1150-1162
Author(s):  
Yu Lin ◽  
Zhanhui Li ◽  
Haikuo Ma ◽  
Yujie Wang ◽  
Xu Wang ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Cyclic Amines ◽  
Cxcr4 Antagonists

Ferrocenyl-nitrogen donor ligands. Synthesis and characterization of rhodium(I) complexes of ferrocenylpyridine and related ligands

2006 ◽  
Vol 691 (22) ◽  
pp. 4573-4588 ◽  
Author(s):  
Jaisheila Rajput ◽  
Alan T. Hutton ◽  
John R. Moss ◽  
Hong Su ◽  
Christopher Imrie
Keyword(s):  
Donor Ligands ◽  
Synthesis And Characterization ◽  
Nitrogen Donor Ligands ◽  
Nitrogen Donor
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