scholarly journals Design, Synthesis, and Biological Evaluation of 3,4-Dihydroquinolin-2(1H)-one and 1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors

2011 ◽  
Vol 54 (15) ◽  
pp. 5562-5575 ◽  
Author(s):  
Jailall Ramnauth ◽  
Joanne Speed ◽  
Shawn P. Maddaford ◽  
Peter Dove ◽  
Subhash C. Annedi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Neuronal Nitric Oxide Synthase ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Oxide Synthase ◽  
Synthesis And Biological Evaluation

scholarly journals N,N′-Disubstituted thiourea and urea derivatives: design, synthesis, docking studies and biological evaluation against nitric oxide synthase

MedChemComm ◽  
2016 ◽  
Vol 7 (4) ◽  
pp. 667-678 ◽  
Author(s):  
Mariem Chayah ◽  
M. Encarnación Camacho ◽  
M. Dora Carrión ◽  
Miguel A. Gallo ◽  
Miguel Romero ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Docking Studies ◽  
Biological Evaluation ◽  
Urea Derivatives ◽  
Design Synthesis ◽  
Inos Inhibitors ◽  
Oxide Synthase

N,N′-Disubstituted thioureas and ureas as nNOS and iNOS inhibitors were synthesized. Thiourea 4g was the best inhibitor without eNOS inhibition.

Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): Synthesis and biological evaluation

2009 ◽  
Vol 17 (17) ◽  
pp. 6180-6187 ◽  
Author(s):  
Rosa M. Claramunt ◽  
Concepción López ◽  
Carlos Pérez-Medina ◽  
Marta Pérez-Torralba ◽  
José Elguero ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Biological Evaluation ◽  
Selective Inhibitors ◽  
Oxide Synthase ◽  
Synthesis And Biological Evaluation
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