Azaindenoisoquinolines as Topoisomerase I Inhibitors and Potential Anticancer Agents: A Systematic Study of Structure–Activity Relationships

Quantitative Structure-Activity Relationship Studies on Indenoisoquinoline Topoisomerase I Inhibitors as Anticancer Agents in Human Renal Cell Carcinoma Cell Line SN12C

International Journal of Molecular Sciences ◽

10.3390/ijms13056009 ◽

2012 ◽

Vol 13 (5) ◽

pp. 6009-6025 ◽

Cited By ~ 3

Author(s):

Yi Zhi ◽

Jin Yang ◽

Shengchao Tian ◽

Fang Yuan ◽

Yang Liu ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Anticancer Agents ◽

Topoisomerase I ◽

Carcinoma Cell ◽

Quantitative Structure Activity Relationship ◽

Quantitative Structure ◽

Human Renal Cell Carcinoma ◽

Renal Cell Carcinoma Cell ◽

The structure–activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.06.040 ◽

2010 ◽

Vol 18 (15) ◽

pp. 5535-5552 ◽

Cited By ~ 12

Author(s):

Maris A. Cinelli ◽

Andrew E. Morrell ◽

Thomas S. Dexheimer ◽

Keli Agama ◽

Surbhi Agrawal ◽

...

Keyword(s):

Topoisomerase I ◽

Binding Mode ◽

Synthesis, cytotoxic activities and structure–activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.02.036 ◽

2008 ◽

Vol 16 (8) ◽

pp. 4617-4625 ◽

Cited By ~ 41

Author(s):

Yu Cheng ◽

Lin-Kun An ◽

Ning Wu ◽

Xiao-Dong Wang ◽

Xian-Zhang Bu ◽

...

Keyword(s):

Topoisomerase I ◽

Cytotoxic Activities ◽

Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome

Molecular Autism ◽

10.1186/s13229-018-0228-2 ◽

2018 ◽

Vol 9 (1) ◽

Cited By ~ 14

Author(s):

Hyeong-Min Lee ◽

Ellen P. Clark ◽

M. Bram Kuijer ◽

Mark Cushman ◽

Yves Pommier ◽

...

Keyword(s):

Angelman Syndrome ◽

Topoisomerase I ◽

Structure Activity ◽

Ube3a Gene

Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: Investigating the hypothesis of shared structure–activity relationships

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.08.066 ◽

2009 ◽

Vol 17 (20) ◽

pp. 7145-7155 ◽

Cited By ~ 29

Author(s):

Maris A. Cinelli ◽

Brenda Cordero ◽

Thomas S. Dexheimer ◽

Yves Pommier ◽

Mark Cushman

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Structure Activity ◽

Synthesis And Biological Evaluation ◽

Shared Structure

Topoisomerase I Inhibitors Derived from Natural Products: Structure–Activity Relationships and Antitumor Potency

Studies in Natural Products Chemistry ◽

10.1016/b978-0-444-63603-4.00001-2 ◽

2016 ◽

pp. 1-28 ◽

Cited By ~ 2

Author(s):

Chunquan Sheng ◽

Zhenyuan Miao ◽

Wannian Zhang

Keyword(s):

Natural Products ◽

Topoisomerase I ◽

1,3,4-Oxadiazole-containing Hybrids as Potential Anticancer Agents: Recent Developments, Mechanism of Action and Structure-Activity Relationships

Journal of Saudi Chemical Society ◽

10.1016/j.jscs.2021.101284 ◽

2021 ◽

pp. 101284

Author(s):

Swarnagowri Nayak ◽

Santosh L. Gaonkar ◽

Ebraheem Abdu Musad ◽

Abdullah Mohammed AL. Dawsar

Keyword(s):

Mechanism Of Action ◽

Anticancer Agents ◽

Structure Activity ◽

Recent Developments

ChemInform Abstract: Structure-Activity Relationships for Analogues of the Phenazine-Based Dual Topoisomerase I/II Inhibitor XR11576.

ChemInform ◽

10.1002/chin.200224170 ◽

2010 ◽

Vol 33 (24) ◽

pp. no-no

Author(s):

Shouming Wang ◽

Warren Miller ◽

John Milton ◽

Nigel Vicker ◽

Alistair Stewart ◽

...

Keyword(s):

Topoisomerase I ◽

Structure Activity ◽

Abstract Structure

Back Cover: Photochemical Properties and Structure-Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents (Eur. J. Inorg. Chem. 12/2017)

European Journal of Inorganic Chemistry ◽

10.1002/ejic.201700259 ◽

2017 ◽

Vol 2017 (12) ◽

pp. 1842-1842

Author(s):

Dmytro Havrylyuk ◽

David K. Heidary ◽

Leona Nease ◽

Sean Parkin ◽

Edith C. Glazer

Keyword(s):

Anticancer Agents ◽

Back Cover ◽

Structure Activity ◽

Photochemical Properties

Selective and effective anticancer agents: Synthesis, biological evaluation and structure-activity relationships of novel carbazole derivatives

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104991 ◽

2021 ◽

pp. 104991

Author(s):

Wenbo Huang ◽

Zilin Gao ◽

Zhigang Zhang ◽

Wei Fang ◽

Zuoqian Wang ◽

...

Keyword(s):

Anticancer Agents ◽

Biological Evaluation ◽

Carbazole Derivatives ◽