scholarly journals 1,3,4-Oxadiazole-containing Hybrids as Potential Anticancer Agents: Recent Developments, Mechanism of Action and Structure-Activity Relationships

2021 ◽  
pp. 101284
Author(s):  
Swarnagowri Nayak ◽  
Santosh L. Gaonkar ◽  
Ebraheem Abdu Musad ◽  
Abdullah Mohammed AL. Dawsar
Keyword(s):  
Mechanism Of Action ◽  
Anticancer Agents ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Recent Developments

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

2020 ◽  
Vol 44 (6) ◽  
pp. 2247-2255
Author(s):  
Qifan Zhou ◽  
Lina Jia ◽  
Fangyu Du ◽  
Xiaoyu Dong ◽  
Wanyu Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Activity Assay ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Enhancer Of Zeste

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining with in vitro biological activity assay and docking results.

5-Cinnamoyl-6-aminouracil derivatives as novel anticancer agents. Synthesis, biological evaluation, and structure-activity relationships

1985 ◽  
Vol 28 (4) ◽  
pp. 497-502 ◽  
Author(s):  
Jean Luc Bernier ◽  
Jean Pierre Henichart ◽  
Vincent Warin ◽  
Chantal Trentesaux ◽  
Jean Claude Jardillier
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Structure Activity Relationships ◽  
Structure Activity

Thiazole in the targeted anticancer drug discovery

2019 ◽  
Vol 11 (15) ◽  
pp. 1929-1952 ◽  
Author(s):  
Adileh Ayati ◽  
Saeed Emami ◽  
Setareh Moghimi ◽  
Alireza Foroumadi
Keyword(s):  
Drug Discovery ◽  
Cancer Therapy ◽  
Mechanism Of Action ◽  
Anticancer Agents ◽  
Causes Of Death ◽  
Structure Activity ◽  
The World ◽  
Cancerous Cells ◽  
Potential Use ◽  
Anticancer Drug Discovery

Cancer is known as one of the main causes of death in the world; and many compounds have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile heterocycle, found in the structure of many drugs in use as well as anticancer agents. This review provides an overview of recent advances in thiazole-bearing compounds as anticancer agents with particular emphasis on their mechanism of action in cancerous cells. Chemical designs, structure–activity relationships and relevant preclinical properties have been comprehensively described.

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