An Aromatic Region To Induce a Switch between Agonism and Inverse Agonism at the Ghrelin Receptor

2012 ◽  
Vol 55 (17) ◽  
pp. 7437-7449 ◽  
Author(s):  
Sylvia Els ◽  
Enrico Schild ◽  
Pia Steen Petersen ◽  
Tom-Marten Kilian ◽  
Jacek Mokrosinski ◽  
...  
Keyword(s):  
Ghrelin Receptor ◽  
Inverse Agonism ◽  
Aromatic Region

C-terminus of a hexapeptidic ghrelin receptor inverse agonist can switch peptide behavior from inverse agonism to agonism

Biopolymers ◽  
2016 ◽  
Vol 106 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Sylvia Els-Heindl ◽  
Kathrin Bellmann-Sickert ◽  
Annette G. Beck-Sickinger
Keyword(s):  
Inverse Agonist ◽  
Ghrelin Receptor ◽  
Inverse Agonism ◽  
C Terminus ◽  
Receptor Inverse Agonist

scholarly journals Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling

2015 ◽  
Vol 290 (45) ◽  
pp. 27021-27039 ◽  
Author(s):  
Céline M'Kadmi ◽  
Jean-Philippe Leyris ◽  
Lauriane Onfroy ◽  
Céline Galés ◽  
Aude Saulière ◽  
...  
Keyword(s):  
Receptor Signaling ◽  
Ghrelin Receptor ◽  
Inverse Agonism

scholarly journals Identification of an Efficacy Switch Region in the Ghrelin Receptor Responsible for Interchange between Agonism and Inverse Agonism

2007 ◽  
Vol 282 (21) ◽  
pp. 15799-15811 ◽  
Author(s):  
Birgitte Holst ◽  
Jacek Mokrosinski ◽  
Manja Lang ◽  
Erik Brandt ◽  
Rie Nygaard ◽  
...  
Keyword(s):  
Switch Region ◽  
Ghrelin Receptor ◽  
Inverse Agonism

Modulation of Ghrelin, a cardiovascular hormone, and Ghrelin-receptor in the myocardium of patients with chronic heart failure

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
A Beiras-Fernandez ◽  
F Weis ◽  
T Pöttinger ◽  
S Kreth ◽  
I Kaczmarek ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Ghrelin Receptor

Ghrelin and Obesity-An Update

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Gandhi M. ◽  
Swaminathan S.
Keyword(s):  
Diabetes Mellitus ◽  
Cardiac Output ◽  
Energy Balance ◽  
Vascular Resistance ◽  
The Body ◽  
Ghrelin Receptor ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Natural Hormones

Ghrelin as human natural hormones is involved in fundamental regulatory process of eating and energy balance. It is a stomach derived hormone that acts as at the ghrelin receptor in multiple tissues throughout to the body. Its properties includes increasing appetite, decreasing systemic inflammation, decreasing vascular resistance ,increasing cardiac output, increasing glucose and IGF-1 levels, Hence it may play a significant role in Diabetes mellitus. Many studies have linked ghrelin to obesity and this paper is an attempt to bring out recent findings on the role of ghrelin in Diabetes Mellitus, particularly type2 Diabetes mellitus.

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