General Synthesis of β-Alanine-Containing Spider Polyamine Toxins and Discovery of Nephila Polyamine Toxins 1 and 8 as Highly Potent Inhibitors of Ionotropic Glutamate Receptors

2012 ◽  
Vol 55 (22) ◽  
pp. 10297-10301 ◽  
Author(s):  
Simon Lucas ◽  
Mette H. Poulsen ◽  
Niels G. Nørager ◽  
Anne F. Barslund ◽  
Tinna B. Bach ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Ionotropic Glutamate Receptors ◽  
General Synthesis ◽  
Polyamine Toxins

scholarly journals Illuminating Ionotropic Glutamate Receptors: Characterization of Fluorescent Antagonists Based on Polyamine Toxins

2013 ◽  
Vol 104 (2) ◽  
pp. 272a
Author(s):  
Christel B. Jensen ◽  
Niels G. Nørager ◽  
Anders S. Kristensen ◽  
Kristian Strømgaard
Keyword(s):  
Glutamate Receptors ◽  
Ionotropic Glutamate Receptors ◽  
Polyamine Toxins

Structure–Activity Relationship Studies of N-Methylated and N-Hydroxylated Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors

2014 ◽  
Vol 57 (11) ◽  
pp. 4940-4949 ◽  
Author(s):  
Niels G. Nørager ◽  
Mette H. Poulsen ◽  
Anna G. Jensen ◽  
Nanna S. Jeppesen ◽  
Anders S. Kristensen ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Structure Activity Relationship ◽  
Ionotropic Glutamate Receptors ◽  
Activity Relationship ◽  
Structure Activity ◽  
Polyamine Toxins

Development of Potent Fluorescent Polyamine Toxins and Application in Labeling of Ionotropic Glutamate Receptors in Hippocampal Neurons

2013 ◽  
Vol 8 (9) ◽  
pp. 2033-2041 ◽  
Author(s):  
Niels G. Nørager ◽  
Christel B. Jensen ◽  
Mette Rathje ◽  
Jacob Andersen ◽  
Kenneth L. Madsen ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Hippocampal Neurons ◽  
Ionotropic Glutamate Receptors ◽  
Polyamine Toxins

Structure-Activity Relationship Study of Spider Polyamine Toxins as Inhibitors of Ionotropic Glutamate Receptors

ChemMedChem ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. 2661-2670 ◽  
Author(s):  
Xiao-Feng Xiong ◽  
Mette H. Poulsen ◽  
Rama A. Hussein ◽  
Niels G. Nørager ◽  
Kristian Strømgaard
Keyword(s):  
Glutamate Receptors ◽  
Structure Activity Relationship ◽  
Ionotropic Glutamate Receptors ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study ◽  
Polyamine Toxins

Glycine agonism in ionotropic glutamate receptors

2021 ◽  
pp. 108631
Author(s):  
David Stroebel ◽  
Laetitia Mony ◽  
Pierre Paoletti
Keyword(s):  
Glutamate Receptors ◽  
Ionotropic Glutamate Receptors

Preparation of domoic acid analogues using a bioconversion system, and their toxicity in mice

2021 ◽  
Author(s):  
Yukari Maeno ◽  
Yuichi Kotaki ◽  
Ryuta Terada ◽  
Masafumi Hidaka ◽  
Yuko Cho ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chemical Synthesis ◽  
Glutamate Receptors ◽  
Domoic Acid ◽  
Ionotropic Glutamate Receptors ◽  
The Central Nervous System ◽  
Potent Agonist

Domoic acid (1, DA), a member of the natural kainoid family, is a potent agonist of ionotropic glutamate receptors in the central nervous system. The chemical synthesis of DA and...

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