The Hippo Pathway and YAP/TAZ–TEAD Protein–Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

2015 ◽  
Vol 58 (12) ◽  
pp. 4857-4873 ◽  
Author(s):  
Matteo Santucci ◽  
Tatiana Vignudelli ◽  
Stefania Ferrari ◽  
Marco Mor ◽  
Laura Scalvini ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Cancer Treatment ◽  
Protein Interaction ◽  
Hippo Pathway ◽  
Protein Protein Interaction ◽  
The Hippo Pathway

scholarly journals Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2715
Author(s):  
Evan R. Barry ◽  
Vladimir Simov ◽  
Iris Valtingojer ◽  
Olivier Venier
Keyword(s):  
Regenerative Medicine ◽  
Small Molecules ◽  
Hippo Pathway ◽  
Therapeutic Approaches ◽  
Tumor Immune Evasion ◽  
Multiple Modalities ◽  
Protein Protein Interaction ◽  
Cancer Settings ◽  
The Hippo Pathway ◽  
Resistance To Chemotherapy

The Hippo pathway is an evolutionary conserved signaling network that regulates essential processes such as organ size, cell proliferation, migration, stemness and apoptosis. Alterations in this pathway are commonly found in solid tumors and can lead to hyperproliferation, resistance to chemotherapy, compensation for mKRAS and tumor immune evasion. As the terminal effectors of the Hippo pathway, the transcriptional coactivators YAP1/TAZ and the transcription factors TEAD1–4 present exciting opportunities to pharmacologically modulate the Hippo biology in cancer settings, inflammation and regenerative medicine. This review will provide an overview of the progress and current strategies to directly and indirectly target the YAP1/TAZ protein–protein interaction (PPI) with TEAD1–4 across multiple modalities, with focus on recent small molecules able to selectively bind to TEAD, block its autopalmitoylation and inhibit YAP1/TAZ–TEAD-dependent transcription in cancer.

scholarly journals Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction

2018 ◽  
Vol 72 (2) ◽  
pp. 328-340.e8 ◽  
Author(s):  
Han Han ◽  
Ruxi Qi ◽  
Jeff Jiajing Zhou ◽  
Albert Paul Ta ◽  
Bing Yang ◽  
...  
Keyword(s):  
Phosphatidic Acid ◽  
Protein Interaction ◽  
Hippo Pathway ◽  
Lipid Protein Interaction ◽  
The Hippo Pathway

scholarly journals Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

2020 ◽  
Vol 19 (7) ◽  
pp. 480-494 ◽  
Author(s):  
Anwesha Dey ◽  
Xaralabos Varelas ◽  
Kun-Liang Guan
Keyword(s):  
Wound Healing ◽  
Regenerative Medicine ◽  
Hippo Pathway ◽  
The Hippo Pathway

scholarly journals Defining the Protein–Protein Interaction Network of the Human Hippo Pathway

2013 ◽  
Vol 13 (1) ◽  
pp. 119-131 ◽  
Author(s):  
Wenqi Wang ◽  
Xu Li ◽  
Jun Huang ◽  
Lin Feng ◽  
Keithlee G. Dolinta ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Protein Interaction Network ◽  
Hippo Pathway ◽  
Interaction Network ◽  
Protein Protein Interaction ◽  
Protein Protein Interaction Network
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