scholarly journals Synthesis and Discovery of High Affinity Folate Receptor-Specific Glycinamide Ribonucleotide Formyltransferase Inhibitors with Antitumor Activity

2008 ◽  
Vol 51 (16) ◽  
pp. 5052-5063 ◽  
Author(s):  
Yijun Deng ◽  
Yiqiang Wang ◽  
Christina Cherian ◽  
Zhanjun Hou ◽  
Steven A. Buck ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Folate Receptor ◽  
Glycinamide Ribonucleotide Formyltransferase ◽  
High Affinity

scholarly journals The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway.

1990 ◽  
Vol 110 (3) ◽  
pp. 637-649 ◽  
Author(s):  
K G Rothberg ◽  
Y S Ying ◽  
J F Kolhouse ◽  
B A Kamen ◽  
R G Anderson
Keyword(s):  
Tissue Culture ◽  
Folate Receptor ◽  
Endocytic Pathway ◽  
Coated Pits ◽  
Folate Binding Protein ◽  
Glycosyl Phosphatidylinositol ◽  
High Affinity ◽  
Culture Cells ◽  
Tissue Culture Cells ◽  
Endocytic Machinery

The folate receptor, also known as the membrane folate-binding protein, is maximally expressed on the surface of folate-depleted tissue culture cells and mediates the high affinity accumulation of 5-methyltetrahydrofolic acid in the cytoplasm of these cells. Recent evidence suggests that this receptor recycles during folate internalization and that it is anchored in the membrane by a glycosyl-phosphatidylinositol linkage. Using quantitative immunocytochemistry, we now show that (a) this receptor is highly clustered on the cell surface; (b) these clusters are preferentially associated with uncoated membrane invaginations rather than clathrin-coated pits; and (c) the receptor is not present in endosomes or lysosomes. This receptor appears to physically move in and out of the cell using a novel uncoated pit pathway that does not merge with the clathrin-coated pit endocytic machinery.

scholarly journals Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity

2020 ◽  
Vol 19 (4) ◽  
pp. 1040-1051 ◽  
Author(s):  
Sun K. Ho ◽  
Zhenghai Xu ◽  
Archana Thakur ◽  
Melvin Fox ◽  
Siu Sze Tan ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Liver Toxicity ◽  
Cross Linking ◽  
High Affinity ◽  
Agonist Antibody

scholarly journals Antitumor Activity of a Novel Double-Targeted System for Folate Receptor-Mediated Delivery of Mitomycin C

ACS Omega ◽  
2020 ◽  
Vol 5 (41) ◽  
pp. 26864-26870
Author(s):  
Yan Xu ◽  
Xiangmei Jin ◽  
Jun Zhang ◽  
Kun Wang ◽  
Xiaoyan Jin ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Mitomycin C ◽  
Folate Receptor

Selective expression of the high-affinity isoform of the folate receptor (FR-α) in the human placental syncytiotrophoblast and choriocarcinoma cells

1994 ◽  
Vol 1223 (1) ◽  
pp. 71-75 ◽  
Author(s):  
Puttur D. Prasad ◽  
Sammanda Ramamoorthy ◽  
Aaron J. Moe ◽  
Carl H. Smith ◽  
Frederick H. Leibach ◽  
...  
Keyword(s):  
Folate Receptor ◽  
High Affinity ◽  
Selective Expression ◽  
Choriocarcinoma Cells

Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport

2011 ◽  
Vol 21 (16) ◽  
pp. 4852-4856 ◽  
Author(s):  
Xi Xiao ◽  
Ju Wu ◽  
Chiara Trigili ◽  
Hui Chen ◽  
Joseph W.K. Chu ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Drug Transport ◽  
Microtubule Binding ◽  
High Affinity

Preparation, In Vitro, and In Vivo Antitumor Activity of Folate Receptor-Targeted Nanoliposomes Containing Oridonin

2012 ◽  
Vol 74 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Chuan-Jin Wang ◽  
Guang-Jun Zhu ◽  
Li Yu ◽  
Bai-Hui Shi
Keyword(s):  
Antitumor Activity ◽  
Folate Receptor ◽  
In Vivo Antitumor Activity

scholarly journals Folate Receptor–Specific Antitumor Activity of EC131, a Folate-Maytansinoid Conjugate

2007 ◽  
Vol 67 (13) ◽  
pp. 6376-6382 ◽  
Author(s):  
Joseph A. Reddy ◽  
Elaine Westrick ◽  
Hari K.R. Santhapuram ◽  
Stephen J. Howard ◽  
Michael L. Miller ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Folate Receptor

scholarly journals High-affinity folate receptor in cardiac neural crest migration: A gene knockdown model using siRNA

2010 ◽  
Vol 239 (4) ◽  
pp. 1136-1144 ◽  
Author(s):  
Thomas H. Rosenquist ◽  
Tammy Chaudoin ◽  
Richard H. Finnell ◽  
Gregory D. Bennett
Keyword(s):  
Neural Crest ◽  
Folate Receptor ◽  
Gene Knockdown ◽  
Cardiac Neural Crest ◽  
High Affinity ◽  
Neural Crest Migration
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