Biarylpyrazolyl Oxadiazole as Potent, Selective, Orally Bioavailable Cannabinoid-1 Receptor Antagonists for the Treatment of Obesity

2008 ◽  
Vol 51 (22) ◽  
pp. 7216-7233 ◽  
Author(s):  
Suk Ho Lee ◽  
Hee Jeong Seo ◽  
Sung-Han Lee ◽  
Myung Eun Jung ◽  
Ji-Hyun Park ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Cannabinoid 1 Receptor ◽  
Orally Bioavailable ◽  
Treatment Of Obesity

Methylsulfonylpyrazolyl oxadiazoles and thiadiazoles as potent, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesity

2009 ◽  
Vol 1 (5) ◽  
pp. 947-967 ◽  
Author(s):  
Hee Jeong Seo ◽  
Min Ju Kim ◽  
Kwang-Seop Song ◽  
Sung-Han Lee ◽  
Myung Eun Jung ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Cannabinoid 1 Receptor ◽  
Orally Bioavailable ◽  
Treatment Of Obesity

Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity

2007 ◽  
Vol 17 (10) ◽  
pp. 2706-2711 ◽  
Author(s):  
Roger A. Smith ◽  
Zahra Fathi ◽  
Furahi Achebe ◽  
Christiana Akuche ◽  
Su-Ellen Brown ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Cannabinoid 1 Receptor ◽  
Amide Derivatives ◽  
Treatment Of Obesity

Discovery of orally bioavailable NK1 receptor antagonists

2003 ◽  
Vol 13 (3) ◽  
pp. 437-442 ◽  
Author(s):  
C. Genicot ◽  
B. Christophe ◽  
P. Collart ◽  
M. Gillard ◽  
L. Goossens ◽  
...  
Keyword(s):  
Nk1 Receptor ◽  
Receptor Antagonists ◽  
Orally Bioavailable ◽  
Nk1 Receptor Antagonists

1-Sulfonyl-4-acylpiperazines as Selective Cannabinoid-1 Receptor (CB1R) Inverse Agonists for the Treatment of Obesity

2009 ◽  
Vol 52 (8) ◽  
pp. 2550-2558 ◽  
Author(s):  
Petr Vachal ◽  
Joan M. Fletcher ◽  
Tung M. Fong ◽  
Cathy C. R.-R. Huang ◽  
Julie Lao ◽  
...  
Keyword(s):  
Inverse Agonists ◽  
Cannabinoid 1 Receptor ◽  
Treatment Of Obesity

Discovery of cannabinoid-1 receptor antagonists by virtual screening

2010 ◽  
Vol 20 (17) ◽  
pp. 5130-5132 ◽  
Author(s):  
Gil Nam Lee ◽  
Kwang Rok Kim ◽  
Sung-Hoon Ahn ◽  
Myung Ae Bae ◽  
Nam Sook Kang
Keyword(s):  
Virtual Screening ◽  
Receptor Antagonists ◽  
Cannabinoid 1 Receptor

ChemInform Abstract: Prospective Therapeutic Agents for Obesity: Molecular Modification Approaches of Centrally and Peripherally Acting Selective Cannabinoid 1 Receptor Antagonists

ChemInform ◽  
2014 ◽  
Vol 45 (29) ◽  
pp. no-no
Author(s):  
Mayank Kumar Sharma ◽  
Prashant R. Murumkar ◽  
Ashish M. Kanhed ◽  
Rajani Giridhar ◽  
Mange Ram Yadav
Keyword(s):  
Therapeutic Agents ◽  
Receptor Antagonists ◽  
Molecular Modification ◽  
Cannabinoid 1 Receptor
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