Pharmacophore Models of Group I and Group II Metabotropic Glutamate Receptor Agonists. Analysis of Conformational, Steric, and Topological Parameters Affecting Potency and Selectivity

Receptor Agonists ◽

Metabotropic Glutamate ◽

Topological Parameters ◽

Group I ◽

Group Ii ◽

Pharmacophore Models

Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons

Journal of Neuroscience ◽

10.1523/jneurosci.1225-08.2008 ◽

2008 ◽

Vol 28 (32) ◽

pp. 8003-8013 ◽

Cited By ~ 75

Author(s):

I. Dumalska ◽

M. Wu ◽

E. Morozova ◽

R. Liu ◽

A. van den Pol ◽

...

Keyword(s):

Glutamate Receptor ◽

Gonadotropin Releasing Hormone ◽

Releasing Hormone ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Group I ◽

Phosphoinositide hydrolysis in vivo with group I metabotropic glutamate receptor agonists

Brain Research ◽

10.1016/s0006-8993(99)01065-3 ◽

1999 ◽

Vol 821 (2) ◽

pp. 539-545 ◽

Cited By ~ 19

Author(s):

Michael P Johnson ◽

Maryjo Chamberlain ◽

Gerard M Kelly

Keyword(s):

Glutamate Receptor ◽

Phosphoinositide Hydrolysis ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Group I ◽

Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists

British Journal of Pharmacology ◽

10.1038/sj.bjp.0701626 ◽

1998 ◽

Vol 123 (3) ◽

pp. 581-589 ◽

Cited By ~ 23

Author(s):

Rajendra Mistry ◽

Nicki Golding ◽

R A. John Challiss

Keyword(s):

Cerebral Cortex ◽

Glutamate Receptor ◽

Neonatal Rat ◽

Rat Cerebral Cortex ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Phosphoinositide Turnover ◽

Group I ◽

Acute pancreatitis decreases the sensitivity of pancreas-projecting dorsal motor nucleus of the vagus neurones to group II metabotropic glutamate receptor agonists in rats

The Journal of Physiology ◽

10.1113/jphysiol.2013.270108 ◽

2014 ◽

Vol 592 (6) ◽

pp. 1411-1421 ◽

Cited By ~ 4

Author(s):

Tanja Babic ◽

R. Alberto Travagli

Keyword(s):

Acute Pancreatitis ◽

Glutamate Receptor ◽

Motor Nucleus ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Dorsal Motor Nucleus ◽

Neuroprotective action of group I metabotropic glutamate receptor agonists against oxygen–glucose deprivation-induced neuronal death

Brain Research ◽

10.1016/s0006-8993(99)02166-6 ◽

2000 ◽

Vol 853 (2) ◽

pp. 370-373 ◽

Cited By ~ 21

Author(s):

Anti Kalda ◽

Allen Kaasik ◽

Vitali Vassiljev ◽

Paavo Pokk ◽

Alexander Zharkovsky

Keyword(s):

Glutamate Receptor ◽

Neuronal Death ◽

Glucose Deprivation ◽

Oxygen Glucose Deprivation ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Group I ◽

Neuroprotective Action

Group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia

European Journal of Pharmacology ◽

10.1016/j.ejphar.2009.12.041 ◽

2010 ◽

Vol 639 (1-3) ◽

pp. 59-66 ◽

Cited By ~ 41

Author(s):

Shigeyuki Chaki

Keyword(s):

Glutamate Receptor ◽

Potential Drug ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Pharmacophore Identification and Bioactivity Prediction for Group I Metabotropic Glutamate Receptor Agonists by the Electron-Conformational QSAR Method

Quantitative Structure-Activity Relationships ◽

10.1002/1521-3838(200111)20:4<327::aid-qsar327>3.0.co;2-q ◽

2001 ◽

Vol 20 (4) ◽

pp. 327-334 ◽

Cited By ~ 10

Author(s):

Eran Rosines ◽

Isaac B. Bersuker ◽

James E. Boggs

Keyword(s):

Glutamate Receptor ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Bioactivity Prediction ◽

Group I ◽

Pharmacophore Identification ◽

Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia

Neuropharmacology ◽

10.1016/j.neuropharm.2011.06.007 ◽

2012 ◽

Vol 62 (3) ◽

pp. 1473-1483 ◽

Cited By ~ 66

Author(s):

Matthew J. Fell ◽

David L. McKinzie ◽

James A. Monn ◽

Kjell A. Svensson

Keyword(s):

Glutamate Receptor ◽

Allosteric Modulators ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Novel Treatments ◽

Positive Allosteric Modulators ◽

Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV

European Journal of Pharmacology ◽

10.1016/s0014-2999(98)00526-3 ◽

1998 ◽

Vol 356 (2-3) ◽

pp. 149-157 ◽

Cited By ~ 64

Author(s):

John Kilbride ◽

LingQian Huang ◽

Michael J. Rowan ◽

Roger Anwyl

Keyword(s):

Glutamate Receptor ◽

Inhibitory Action ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Anti-epileptic activity of group II metabotropic glutamate receptor agonists (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (−)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795)

Neuropharmacology ◽

10.1016/s0028-3908(01)00044-2 ◽

2001 ◽

Vol 41 (1) ◽

pp. 8-18 ◽

Cited By ~ 43

Author(s):

R.X. Moldrich ◽

M. Jeffrey ◽

A. Talebi ◽

P.M. Beart ◽

A.G. Chapman ◽

...

Keyword(s):

Glutamate Receptor ◽

Epileptic Activity ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽