Radical Addition Reactions to Allylstannanes Having Substituents at C-1. Highly Efficient Synthesis of Enantiomerically Pure .alpha.-Alkylcyclopentenones, the Key Component for Synthesis of Prostaglandins by the Two-Component Coupling Process

1994 ◽  
Vol 59 (21) ◽  
pp. 6153-6155 ◽  
Author(s):  
Yukio Yoshida ◽  
Naoya Ono ◽  
Fumie Sato
Keyword(s):  
Radical Addition ◽  
Addition Reactions ◽  
Efficient Synthesis ◽  
Enantiomerically Pure ◽  
Coupling Process ◽  
Highly Efficient ◽  
Two Component

Rhodium(iii)-catalyzed tandem reaction: efficient synthesis of dihydrobenzo thiadiazine 1-oxide derivatives

2019 ◽  
Vol 6 (9) ◽  
pp. 1458-1462 ◽  
Author(s):  
Yang Li ◽  
Chen-Fei Liu ◽  
Xin-Yang Liu ◽  
Yan-Jun Xu ◽  
Lin Dong
Keyword(s):  
Tandem Reaction ◽  
Efficient Synthesis ◽  
Highly Efficient ◽  
Two Component

A tandem annulation reaction triggered by rhodium(iii)-catalyzed C–H bond functionalizations has been well developed for highly efficient synthesis of dihydrobenzo thiadiazine 1-oxide derivatives from free NH-sulfoximine and two-component benzyl azides.

scholarly journals Synthesis of enantiomerically pure N-(2,3-dihydroxypropyl)arylamides via oxidative esterification

2013 ◽  
Vol 9 ◽  
pp. 2129-2136 ◽  
Author(s):  
Akula Raghunadh ◽  
Satish S More ◽  
T Krishna Chaitanya ◽  
Yadla Sateesh Kumar ◽  
Suresh Babu Meruva ◽  
...  
Keyword(s):  
Ring Opening ◽  
Efficient Synthesis ◽  
Enantiomerically Pure ◽  
Step Process ◽  
Oxidative Esterification ◽  
Highly Efficient ◽  
Chiral Purity ◽  
High Yields ◽  
Nitrogen Heterocyclic

A highly efficient synthesis of enantiomerically pure (S) and (R)-isomers of N-(2,3-dihydroxypropyl)arylamides has been developed with good overall yields in a two step process. The key step involves the ring opening of the chiral epoxide with a nitrogen heterocyclic carbene (NHC) and further rearrangement to chiral N-(2,3-dihydroxypropyl)arylamides in high yields and enantioselectivity. During the reaction, no erosion in chiral purity was observed.

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