Facile synthesis of .beta.-aryl- or .beta.-alkenyl-.beta.-methyl-.alpha.,.beta.-unsaturated carbonyl compounds by palladium catalyzed reaction of 1,2-dien-4-ols with aryl or alkenyl halides

1985 ◽  
Vol 50 (4) ◽  
pp. 537-539 ◽  
Author(s):  
Isao Shimizu ◽  
Teruo Sugiura ◽  
Jiro Tsuji
Keyword(s):  
Carbonyl Compounds ◽  
Facile Synthesis ◽  
Palladium Catalyzed ◽  
Alpha Beta

A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

2015 ◽  
Vol 12 (1) ◽  
pp. 3910-3918 ◽  
Author(s):  
Dr Remon M Zaki ◽  
Prof Adel M. Kamal El-Dean ◽  
Dr Nermin A Marzouk ◽  
Prof Jehan A Micky ◽  
Mrs Rasha H Ahmed
Keyword(s):  
Biological Activity ◽  
Carbonyl Compounds ◽  
Mass Spectra ◽  
The Other ◽  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
High Biological Activity ◽  
Basic Hydrolysis ◽  
Pyridine Carboxylate ◽  
Hydrolysis Of

 Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

Palladium‐Catalyzed Regioselective Coupling of Amidines and 1,2,3‐Triiodobenzenes: Facile Synthesis of 2,3‐Diiodinated N ‐Arylbenzimidamides as Potential MDM 2 and MDM 4 Inhibitors

2021 ◽  
Vol 6 (14) ◽  
pp. 3417-3423
Author(s):  
Raed M. Al‐Zoubi ◽  
Walid K. Al‐Jammal ◽  
Mazhar S. Al‐Zoubi ◽  
Michael J. Ferguson ◽  
Ahmad Zarour ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Palladium Catalyzed

Facile Synthesis of α-Keto Acids and Esters by Palladium-Catalyzed Decarboxylation Reactions of Diallyl α-Oxalcarboxylates

1989 ◽  
Vol 18 (8) ◽  
pp. 1457-1460 ◽  
Author(s):  
Isao Shimizu ◽  
Toshiyuki Makuta ◽  
Masato Oshima
Keyword(s):  
Facile Synthesis ◽  
Keto Acids ◽  
Palladium Catalyzed

scholarly journals Hypervalent iodine oxidation of .ALPHA.,.BETA.-unsaturated carbonyl compounds.

1987 ◽  
Vol 35 (2) ◽  
pp. 570-577 ◽  
Author(s):  
YASUMITSU TAMURA ◽  
TAKAYUKI YAKURA ◽  
HIROAKI TERASHI ◽  
JUN-ICHI HARUTA ◽  
YASUYUKI KITA
Keyword(s):  
Carbonyl Compounds ◽  
Hypervalent Iodine ◽  
Alpha Beta

Organic reactions using sodium hydrogentelluride. 3. The Reaction of Sodium Hydrogentelluride with .alpha.,.beta.-Unsaturated Carbonyl Compounds

1994 ◽  
Vol 59 (12) ◽  
pp. 3500-3502 ◽  
Author(s):  
Masakazu Yamashita ◽  
Yoshifumi Tanaka ◽  
Akishi Arita ◽  
Minoru Nishida
Keyword(s):  
Carbonyl Compounds ◽  
Organic Reactions ◽  
Alpha Beta
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