Studies Directed toward the Stereochemical Structure Determination of the Naturally Occurring Glucosidase Inhibitor, Kotalanol: Synthesis and Inhibitory Activities against Human Maltase Glucoamylase of Seven-Carbon, Chain-Extended Homologues of Salacinol

2008 ◽  
Vol 73 (16) ◽  
pp. 6172-6181 ◽  
Author(s):  
Ravindranath Nasi ◽  
Brian O. Patrick ◽  
Lyann Sim ◽  
David R. Rose ◽  
B. Mario Pinto

2005 ◽  
Vol 358 (11) ◽  
pp. 3272-3276 ◽  
Author(s):  
Esther de la Encarnación ◽  
Josefina Pons ◽  
Ramón Yáñez ◽  
Josep Ros






1986 ◽  
Vol 51 (9) ◽  
pp. 1615-1616 ◽  
Author(s):  
Florence K. Gleason ◽  
Joseph Porwoll ◽  
Judith L. Flippen-Anderson ◽  
Clifford George


The Copley Medal is awarded to Professor R. B. Woodward, ForMem. R. S. Professor Woodward is universally acknowledged to be the leading organic chemist of his generation. He has constantly been attracted by the chemistry of naturally occurring substances and his work has transformed the field. He recognized at a very early stage that spectroscopy allowed a control of synthetic and degradative research that could not previously have been contemplated. He made major contributions to the structure determination of complex molecules from widely different classes of compounds, including penicillin, strych­nine, patulin, gelsemine, cevine, aureomycin, calycanthine and tetrodotoxin.



The Copley Medal is awarded to Professor R. B. Woodward, For.Mem.R. S. Professor Woodward is universally acknowledged to be the leading organic chemist of his generation. He has constantly been attracted by the chemistry of naturally occurring substances and his work has transformed the field. He recognized at a very early stage that spectroscopy allowed a control of synthetic and degradative research that could not previously have been contemplated. He made major contributions to the structure determination of complex molecules from widely different classes of compounds, including penicillin, strychnine, patulin, gelsemine, cevine, aureomycin, calycanthine and tetrodotoxin. However, Woodward’s brilliance can best be seen in his many beautiful syntheses, for which he was awarded the Nobel Prize for Chemistry in 1965. Some of his most important syntheses are of quinine, cholesterol cortisone, reserpine, lysergic acid, strychnine, chlorophyll, and cephalosporin. Quite recently he has accomplished, in collaboration with Eschenmoser, the most demanding synthesis ever attempted, that of vitamin B 12 . Woodward brings to his synthetic attack a logic of remarkable precision, a profound understanding of reaction mechanism and stereochemistry, and an indomitable courage.





1990 ◽  
Vol 43 (1) ◽  
pp. 49-53 ◽  
Author(s):  
SONOKO ATSUMI ◽  
KAZUO UMEZAWA ◽  
HIRONOBU IINUMA ◽  
HIROSHI NAGANAWA ◽  
HIKARU NAKAMURA ◽  
...  


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