Encapsulation and Diffusion of Water-Soluble Dendrimers in a Bicontinuous Cubic Phase

Langmuir ◽  
2002 ◽  
Vol 18 (4) ◽  
pp. 1073-1076 ◽  
Author(s):  
Sang Won Jeong ◽  
Greger Orädd ◽  
Göran Lindblom
1993 ◽  
Vol 331 ◽  
Author(s):  
S. Puvvada ◽  
J. Naciri ◽  
B. R. Ratna

AbstractRelease studies from a lipid-based matrix, known as the bicontinuous cubic phase, are presented. This matrix consists of nano-sized pores within which various proteins and drugs can be dispersed and subsequently released to the exterior. To control the release rate, the aqueous pores of the cubic phase were gelled using sodium alginate, a water soluble polysaccharide. Studies show that the release rate is significantly lowered upon gelation and the first order release profile exhibited by the ungelled cubic phase is converted to a zeroorder linear profile. Further, it has been shown that the release trends can be reversed by degelation. This opens up the possibility of releasing large quantities of the protein when required (drugs on demand concept) by degelling the gelled samples.


2003 ◽  
Vol 260 (2) ◽  
pp. 404-413 ◽  
Author(s):  
Matthew L. Lynch ◽  
Akua Ofori-Boateng ◽  
Amanda Hippe ◽  
Kelly Kochvar ◽  
Patrick T. Spicer

Author(s):  
David M. Anderson ◽  
Tomas Landh

First discovered in surfactant-water liquid crystalline systems, so-called ‘bicontinuous cubic phases’ have the property that hydropnilic and lipophilic microdomains form interpenetrating networks conforming to cubic lattices on the scale of nanometers. Later these same structures were found in star diblock copolymers, where the simultaneous continuity of elastomeric and glassy domains gives rise to unique physical properties. Today it is well-established that the symmetry and topology of such a morphology are accurately described by one of several triply-periodic minimal surfaces, and that the interface between hydrophilic and hydrophobic, or immiscible polymer, domains is described by a triply-periodic surface of constant, nonzero mean curvature. One example of such a dividing surface is shown in figure 5.The study of these structures has become of increasing importance in the past five years for two reasons:1)Bicontinuous cubic phase liquid crystals are now being polymerized to create microporous materials with monodispersed pores and readily functionalizable porewalls; figure 3 shows a TEM from a polymerized surfactant / methylmethacrylate / water cubic phase; and2)Compelling evidence has been found that these same morphologies describe biomembrane systems in a wide range of cells.


Soft Matter ◽  
2021 ◽  
Author(s):  
Patrick Li ◽  
Maria I. Reinhardt ◽  
Samantha S. Dyer ◽  
Kara E. Moore ◽  
Omar Q. Imran ◽  
...  

Seven homologues of an amphiphilic gemini monomer were synthesized; and four of them (highlighted in red in the table) were found to form a bicontinuous cubic (Q) phase with glycerol or water and could be radically cross-linked with phase retention.


Nanoscale ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 2471-2478 ◽  
Author(s):  
Thomas G. Meikle ◽  
Shenggen Yao ◽  
Alexandru Zabara ◽  
Charlotte E. Conn ◽  
Calum J. Drummond ◽  
...  

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 68685-68694 ◽  
Author(s):  
Thomas G. Meikle ◽  
Charlotte E. Conn ◽  
Frances Separovic ◽  
Calum J. Drummond

Lipid based bicontinuous cubic mesophases provide a low-cost, robust membrane mimetic nanomaterial which allows for the incorporation of membrane peptides and proteins.


2016 ◽  
Vol 55 (5) ◽  
pp. 464-471 ◽  
Author(s):  
Timothy J. Larkin ◽  
Christopher J. Garvey ◽  
Dmitry Shishmarev ◽  
Philip W. Kuchel ◽  
Konstantin I. Momot

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