Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes

Preclinical Species and Human Disposition of PF-04971729, a Selective Inhibitor of the Sodium-Dependent Glucose Cotransporter 2 and Clinical Candidate for the Treatment of Type 2 Diabetes Mellitus

Drug Metabolism and Disposition ◽

10.1124/dmd.111.040675 ◽

2011 ◽

Vol 39 (9) ◽

pp. 1609-1619 ◽

Cited By ~ 53

Author(s):

Amit S. Kalgutkar ◽

Meera Tugnait ◽

Tong Zhu ◽

Emi Kimoto ◽

Zhuang Miao ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Selective Inhibitor ◽

Sodium Dependent ◽

Preclinical Species ◽

Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Journal of Medicinal Chemistry ◽

10.1021/jm2014887 ◽

2012 ◽

Vol 55 (3) ◽

pp. 1318-1333 ◽

Cited By ~ 87

Author(s):

Jeffrey A. Pfefferkorn ◽

Angel Guzman-Perez ◽

John Litchfield ◽

Robert Aiello ◽

Judith L. Treadway ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Nicotinic Acid ◽

Glucokinase Activator ◽

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

MedChemComm ◽

10.1039/c1md00116g ◽

2011 ◽

Vol 2 (9) ◽

pp. 828 ◽

Cited By ~ 48

Author(s):

Jeffrey A. Pfefferkorn ◽

Angel Guzman-Perez ◽

Peter J. Oates ◽

John Litchfield ◽

Gary Aspnes ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Glucokinase Activators ◽

Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes

European Journal of Pharmacology ◽

10.1016/j.ejphar.2014.10.053 ◽

2015 ◽

Vol 746 ◽

pp. 50-55 ◽

Cited By ~ 19

Author(s):

Bradford S. Hamilton ◽

Frank Himmelsbach ◽

Herbert Nar ◽

Annette Schuler-Metz ◽

Paula Krosky ◽

...

Keyword(s):

Type 2 Diabetes ◽

Hydroxysteroid Dehydrogenase ◽

Pharmacological Characterization ◽

Cardiovascular disease and risk factors in persons with type 2 diabetes diagnosed in a large population screening: The Nord-Trondelag Diabetes Study, Norway

Journal of Internal Medicine ◽

10.1046/j.1365-2796.2000.00759.x ◽

2000 ◽

Vol 248 (6) ◽

pp. 492-500 ◽

Cited By ~ 16

Author(s):

T. Claudi ◽

K. Midthjell ◽

J. Holmen ◽

K. Fougner ◽

O. Kruger ◽

...

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Large Population ◽

Population Screening

M.530 Elevated ambulatory pulse pressure in patients with type 2 diabetes mellitus

Atherosclerosis ◽

10.1016/s0021-9150(04)90528-x ◽

2004 ◽

Vol 5 (1) ◽

pp. 122-123

Author(s):

R HERMIDA

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Pulse Pressure ◽

Ambulatory Pulse Pressure

M.463 Use of rosuvastatin versus atorvastatin in type 2 diabetes mellitus subjects: Results of the uranus study

Atherosclerosis ◽

10.1016/s0021-9150(04)90461-3 ◽

2004 ◽

Vol 5 (1) ◽

pp. 107 ◽

Cited By ~ 1

Author(s):

C BERNE

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus

M.479 Prevalence of an altered nocturnal decline of blood pressure in hypertensive patients with type 2 diabetes

Atherosclerosis ◽

10.1016/s0021-9150(04)90477-7 ◽

2004 ◽

Vol 5 (1) ◽

pp. 111

Author(s):

C CALVO

Keyword(s):

Blood Pressure ◽

Type 2 Diabetes ◽

Hypertensive Patients

1045: Pioglitazone Ameliorates Penile Corpora Veno-Occlusive Dysfunction (CVOD) in a Rat Model of Type 2 Diabetes

The Journal of Urology ◽

10.1016/s0022-5347(18)35201-7 ◽

2005 ◽

Vol 173 (4S) ◽

pp. 283-284

Author(s):

Istvan Kovanecz ◽

Monica G. Ferrini ◽

Hugo H. Davila ◽

Jacob Rajfer ◽

Nestor F. Gonzalez-Cadavid

Keyword(s):

Type 2 Diabetes ◽

Rat Model

Youths With Type 2 Diabetes May Face Triple the CV Risk

Pediatric News ◽

10.1016/s0031-398x(08)70481-8 ◽

2008 ◽

Vol 42 (10) ◽

pp. 1-4

Author(s):

MIRIAM E. TUCKER

Keyword(s):

Type 2 Diabetes