Australine, a Novel Pyrrolizidine Alkaloid Glucosidase Inhibitor from Castanospermum australe

1988 ◽  
Vol 51 (6) ◽  
pp. 1198-1206 ◽  
Author(s):  
Russell J. Molyneux ◽  
Mabry Benson ◽  
Rosalind Y. Wong ◽  
Joseph E. Tropea ◽  
Alan D. Elbein
Keyword(s):  
Pyrrolizidine Alkaloid ◽  
Glucosidase Inhibitor ◽  
Castanospermum Australe

Naturally Occurring Pyrrolizidines: Inhibition of α-Glucosidase 1 and Anti-HIV Activity of One Stereoisomer

1992 ◽  
Vol 3 (5) ◽  
pp. 273-277 ◽  
Author(s):  
D. L. Taylor ◽  
R. Nash ◽  
L. E. Fellows ◽  
M. S. Kang ◽  
A. S. Tyms
Keyword(s):  
Inhibitory Activity ◽  
Pyrrolizidine Alkaloid ◽  
Virus Growth ◽  
Processing Enzymes ◽  
Naturally Occurring ◽  
Antiviral Effects ◽  
Castanospermum Australe ◽  
Glycoprotein Processing ◽  
Anti Hiv ◽  
Hiv 1

Alexine, a naturally occurring pyrrolizidine alkaloid, isolated from Alexa leiopetala, and four stereoisomers, isolated from Castanospermum australe, were investigated for inhibitory activity against the growth of HIV-1. Only treatment with the 7,7a-diepialexine restricted virus growth (IC50 0.38 mm) although it was less active than the indolizidine alkaloid castanospermine (IC50 0.02 mm). The antiviral effects of 7,7a-diepialexine, like castanospermine, correlated with the inhibitory activity against purified pig kidney α-glucosidase 1 of the glycoprotein processing enzymes and the reduced cleavage of the precursor HIV-1 glycoprotein gp160.

Isolation of the pyrrolizidine alkaloid 1-epialexine from Castanospermum australe

2010 ◽  
Vol 3 (3) ◽  
pp. 133-135 ◽  
Author(s):  
Laurence Jones ◽  
Jacqueline Hollinshead ◽  
George W.J. Fleet ◽  
Amber L. Thompson ◽  
David J. Watkin ◽  
...  
Keyword(s):  
Pyrrolizidine Alkaloid ◽  
Castanospermum Australe

1-Epiastraline, a new pyrrolizidine alkaloid from Castanospermum australe

1989 ◽  
Vol 30 (42) ◽  
pp. 5685-5688 ◽  
Author(s):  
Constance M. Harris ◽  
Thomas M. Harris ◽  
Russell J. Molyneux ◽  
Joseph E. Tropea ◽  
Alan D. Elbein
Keyword(s):  
Pyrrolizidine Alkaloid ◽  
Castanospermum Australe

α-amylase and α-glucosidase inhibitor activities of secondary metabolites from Arcytophyllum thymifolium

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
M De Leo ◽  
A Braca ◽  
MB Vera Saltos ◽  
I Faraone ◽  
N Malafronte ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Glucosidase Inhibitor

Acute lung injury induced by the pyrrolizidine alkaloid monocrotaline in mice

Pneumologie ◽  
2006 ◽  
Vol 60 (S 1) ◽  
Author(s):  
R Dumitrascu ◽  
S Köbrich ◽  
H Traupe ◽  
E Dony ◽  
S Pullamsetti ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Pyrrolizidine Alkaloid
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