scholarly journals Riboproteomics of the Hepatitis C Virus Internal Ribosomal Entry Site

2004 ◽  
Vol 3 (5) ◽  
pp. 949-957 ◽  
Author(s):  
Henry Lu ◽  
Weiqun Li ◽  
William Stafford Noble ◽  
Donald Payan ◽  
D. C. Anderson
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosomal Entry Site ◽  
Entry Site ◽  
Ribosomal Entry

scholarly journals CRISPR-Cas13a mediated targeting of hepatitis C virus internal-ribosomal entry site (IRES) as an effective antiviral strategy

2021 ◽  
Vol 136 ◽  
pp. 111239
Author(s):  
Muhammad Usman Ashraf ◽  
Hafiz Muhammad Salman ◽  
Muhammad Farhan Khalid ◽  
Muhammad Haider Farooq Khan ◽  
Saima Anwar ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosomal Entry Site ◽  
Entry Site ◽  
Ribosomal Entry

scholarly journals Hepatitis C Virus Translation Inhibitors Targeting the Internal Ribosomal Entry Site

2013 ◽  
Vol 57 (5) ◽  
pp. 1694-1707 ◽  
Author(s):  
Sergey M. Dibrov ◽  
Jerod Parsons ◽  
Maia Carnevali ◽  
Shu Zhou ◽  
Kevin D. Rynearson ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosomal Entry Site ◽  
Entry Site ◽  
Ribosomal Entry

Down-regulation of translation driven by hepatitis C virus internal ribosomal entry site by the 3′ untranslated region of RNA

2001 ◽  
Vol 146 (4) ◽  
pp. 729-741 ◽  
Author(s):  
K. Murakami ◽  
M. Abe ◽  
T. Kageyama ◽  
N. Kamoshita ◽  
A. Nomoto
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Untranslated Region ◽  
Internal Ribosomal Entry Site ◽  
Entry Site ◽  
Down Regulation ◽  
Regulation Of Translation ◽  
Ribosomal Entry

scholarly journals Ribosomal Protein S5 Interacts with the Internal Ribosomal Entry Site of Hepatitis C Virus

2001 ◽  
Vol 276 (24) ◽  
pp. 20824-20826 ◽  
Author(s):  
Shuetsu Fukushi ◽  
Masato Okada ◽  
Joachim Stahl ◽  
Tsutomu Kageyama ◽  
Fuminori B. Hoshino ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Ribosomal Protein ◽  
Internal Ribosomal Entry Site ◽  
Entry Site ◽  
Ribosomal Entry

scholarly journals microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Philipp Schult ◽  
Hanna Roth ◽  
Rebecca L. Adams ◽  
Caroline Mas ◽  
Lionel Imbert ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosomal Entry Site ◽  
Entry Site ◽  
Ribosomal Entry

scholarly journals An Enzymatic Footprinting Analysis of the Interaction of 40S Ribosomal Subunits with the Internal Ribosomal Entry Site of Hepatitis C Virus

2000 ◽  
Vol 74 (14) ◽  
pp. 6242-6250 ◽  
Author(s):  
Victoria G. Kolupaeva ◽  
Tatyana V. Pestova ◽  
Christopher U. T. Hellen
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Internal Ribosomal Entry Site ◽  
Initiation Codon ◽  
Entry Site ◽  
Interaction Sites ◽  
Ribosomal Entry ◽  
Binding Cleft ◽  
Domain Iii ◽  
Mrna Binding

ABSTRACT Hepatitis C virus translation is initiated on a ∼330-nucleotide (nt)-long internal ribosomal entry site (IRES) at the 5′ end of the genome. In this process, a 43S preinitiation complex (comprising a 40S ribosomal subunit, eukaryotic initiation factor 3 (eIF3), and a ternary [eIF2-GTP-initiator tRNA] complex) binds the IRES in a precise manner so that the initiation codon is placed at the ribosomal P site. This binding step involves specific interactions between the IRES and different components of the 43S complex. The 40S subunit and eIF3 can bind to the IRES independently; previous analyses revealed that eIF3 binds specifically to an apical half of IRES domain III. Nucleotides in the IRES that are involved in the interaction with the 40S subunit were identified by RNase footprinting and mapped to the basal half of domain III and in domain IV. Interaction sites were identified in locations that have been found to be essential for IRES function, including (i) the apical loop residues GGG266-268 in subdomain IIId and (ii) the pseudoknot. Extensive protection from RNase cleavage also occurred downstream of the pseudoknot in domain IV, flanking both sides of the initiation codon and corresponding in length to that of the mRNA-binding cleft of the 40S subunit. These results indicate that the 40S subunit makes multiple interactions with the IRES and suggest that only nucleotides in domain IV are inserted into the mRNA-binding cleft of the 40S subunit.

Cell cycle regulation of hepatitis C virus internal ribosomal entry site–directed translation

2000 ◽  
Vol 118 (1) ◽  
pp. 152-162 ◽  
Author(s):  
Masao Honda ◽  
Shuichi Kaneko ◽  
Eiki Matsushita ◽  
Kenichi Kobayashi ◽  
Geoffrey A. Abell ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cell Cycle Regulation ◽  
Internal Ribosomal Entry Site ◽  
Entry Site ◽  
Ribosomal Entry ◽  
Cycle Regulation
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