Prädilektion des Malleolus medialis beim mit hämolytischer Anämie assoziierten Ulcus cruris

VASA ◽  
2002 ◽  
Vol 31 (3) ◽  
pp. 191-193 ◽  
Author(s):  
Sawhney ◽  
Weedon ◽  
Gillette ◽  
Solomon ◽  
Braverman
Keyword(s):  
Sickle Cell ◽  
Hereditary Spherocytosis ◽  
Ulcus Cruris ◽  
Venous Stasis ◽  
Leg Ulcers ◽  
Cell Disease ◽  
Common Site ◽  
The Difference ◽  
Ischemic Ulcers ◽  
Chronic Hemolytic Anemia

Backround: Ischemic ulcers are usually found above the lateral, and venous stasis ulcers at the medial malleoli. Leg ulcers occur in at least 25% of sickle cell disease (SSD) patients in clinic populations, usually in the malleolar region. The function of the large leg veins in most SSD patients is unimpaired. Patients and methods: We determined leg ulcer location in 41 sickle cell anemia (SS), and 4 sickle-b0 thalassemic patients with longstanding chronic and/or recurrent leg ulceration, and reviewed published reports of leg ulcers in hereditary spherocytosis and thalassemias. Results: Of the 57 legs of the 45 SSD patients with only 1 ulcer, 42 (74%) were medial and 15 lateral. The difference was significant (p < 0.001). Of patients with only a single ulcer, 22 were medial and 4 lateral. Of 15 reported patients with leg ulcers related to spherocytosis or thalassemia, 20/24 (83%) ulcers were medial. Conclusions: The medial malleoli are the most common site of leg ulceration in SSD and in other chronic hemolytic anemias. This suggests that stasis may play a role in the leg ulceration associated with chronic hemolytic anemia.

scholarly journals Treatment dilemmas: strategies for priapism, chronic leg ulcer disease, and pulmonary hypertension in sickle cell disease

Hematology ◽  
2021 ◽  
Vol 2021 (1) ◽  
pp. 411-417
Author(s):  
Roberta C.G. Azbell ◽  
Payal Chandarana Desai
Keyword(s):  
Pulmonary Hypertension ◽  
Sickle Cell Disease ◽  
Hemolytic Anemia ◽  
Sickle Cell ◽  
Acute Chest Syndrome ◽  
Leg Ulcers ◽  
Cell Disease ◽  
Ulcer Disease ◽  
Multiorgan Disease ◽  
Chronic Hemolytic Anemia

Abstract Sickle cell disease is a disorder characterized by chronic hemolytic anemia and multiorgan disease complications. Although vaso-occlusive episodes, acute chest syndrome, and neurovascular disease frequently result in complication and have well-documented guidelines for management, the management of chronic hemolytic and vascular-related complications, such as priapism, leg ulcers, and pulmonary hypertension, is not as well recognized despite their increasing reported prevalence and association with morbidity and mortality. This chapter therefore reviews the current updates on diagnosis and management of priapism, leg ulcers, and pulmonary hypertension.

scholarly journals Effects of Genotypes and Treatment on Oxygenscan Parameters in Sickle Cell Disease

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 811
Author(s):  
Camille Boisson ◽  
Minke A. E. Rab ◽  
Elie Nader ◽  
Céline Renoux ◽  
Celeste Kanne ◽  
...  
Keyword(s):  
Steady State ◽  
Sickle Cell Disease ◽  
Blood Cell ◽  
Sickle Cell ◽  
Red Blood Cell ◽  
Cell Disease ◽  
Oxygen Gradient ◽  
Acute Complication ◽  
Adults And Children ◽  
The Difference

(1) Background: The aim of the present study was to compare oxygen gradient ektacytometry parameters between sickle cell patients of different genotypes (SS, SC, and S/β+) or under different treatments (hydroxyurea or chronic red blood cell exchange). (2) Methods: Oxygen gradient ektacytometry was performed in 167 adults and children at steady state. In addition, five SS patients had oxygenscan measurements at steady state and during an acute complication requiring hospitalization. (3) Results: Red blood cell (RBC) deformability upon deoxygenation (EImin) and in normoxia (EImax) was increased, and the susceptibility of RBC to sickle upon deoxygenation was decreased in SC patients when compared to untreated SS patients older than 5 years old. SS patients under chronic red blood cell exchange had higher EImin and EImax and lower susceptibility of RBC to sickle upon deoxygenation compared to untreated SS patients, SS patients younger than 5 years old, and hydroxyurea-treated SS and SC patients. The susceptibility of RBC to sickle upon deoxygenation was increased in the five SS patients during acute complication compared to steady state, although the difference between steady state and acute complication was variable from one patient to another. (4) Conclusions: The present study demonstrates that oxygen gradient ektacytometry parameters are affected by sickle cell disease (SCD) genotype and treatment.

Common, But Neglected: A Comprehensive Review of Leg Ulcers in Sickle Cell Disease

2021 ◽  
Vol 34 (8) ◽  
pp. 423-431
Author(s):  
Tarun Sahu ◽  
Henu Kumar Verma ◽  
Satyaki Ganguly ◽  
Meenakshi Sinha ◽  
Ramanjan Sinha
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Leg Ulcers ◽  
Cell Disease ◽  
Comprehensive Review

Interventions for treating leg ulcers in people with sickle cell disease

2010 ◽  
Author(s):  
Arturo J Martí-Carvajal ◽  
Maria José Martinez-Zapata ◽  
Jennifer M Knight-Madden
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Leg Ulcers ◽  
Cell Disease

scholarly journals Comparison of pulse oximetry and earlobe blood gas with CO-oximetry in children with sickle cell disease: a retrospective review

2020 ◽  
Vol 4 (1) ◽  
pp. e000690
Author(s):  
Michele Arigliani ◽  
Sean Zheng ◽  
Gary Ruiz ◽  
Subarna Chakravorty ◽  
Cara J Bossley ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Oxygen Saturation ◽  
Pulse Oximetry ◽  
Sickle Cell ◽  
Blood Gas ◽  
Cell Disease ◽  
Arterial Blood ◽  
Ambulatory Patients ◽  
The Difference ◽  
Age Range

ObjectivesTo investigate the agreement between pulse oximetry (SpO2) and oxygen saturation (SaO2) measured by CO-oximetry on arterialised earlobe blood gas (EBG) in children and adolescents with sickle cell disease (SCD).Design and settingWe retrospectively reviewed 39 simultaneous and paired SaO2 EBG and SpO2 measurements from 33 ambulatory patients with SCD (32 subjects with Haemoglobin SS and one with Haemoglobin Sß+, 52% male, mean±SD age 11.0±3.6, age range 5–18). Measurements were performed between 2012 and 2015 when participants were asymptomatic. Hypoxaemia was defined as SaO2 ≤93%. A Bland-Altman analysis was performed to assess the accuracy of SpO2 as compared with EBG SaO2.ResultsThe mean±SD SpO2 and SaO2 values in the same patients were, respectively, 93.6%±3.7% and 94.3%±2.9%. The bias SpO2–SaO2 was −0.7% (95% limits of agreement from −5.4% to 4.1%) and precision was 2.5%. In 9/39 (23%) cases, the difference in SpO2–SaO2 was greater than the expected error range ±2%, with SaO2 more often underestimated by SpO2 (6/9), especially at SpO2values ≤93%. Thirteen participants (33%) were hypoxaemic. The sensitivity of SpO2 for hypoxaemia was 100%, specificity 85% and positive predictive value 76%.ConclusionsPulse oximetry was inaccurate in almost a quarter of measurements in ambulatory paediatric patients with SCD, especially at SpO2values ≤93%. In these cases, oxygen saturation can be confirmed through EBG CO-oximetry, which is easier to perform and less painful than traditional arterial blood sampling.

scholarly journals A new treatment paradigm for sickle cell disease leg ulcers: Topical cannabis‐based medicines

2020 ◽  
Author(s):  
Vincent Maida ◽  
Runjie Bill Shi ◽  
Francesco Gabriele Tatangelo Fazzari ◽  
Lydia‐Marie Zomparelli
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Leg Ulcers ◽  
Cell Disease ◽  
Treatment Paradigm ◽  
New Treatment

scholarly journals Leg Ulcers in Sickle-Cell Disease: Treatment Update

2020 ◽  
Vol 9 (6) ◽  
pp. 348-356 ◽  
Author(s):  
Jean-Benoît Monfort ◽  
Patricia Senet
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Leg Ulcers ◽  
Cell Disease ◽  
Disease Treatment

scholarly journals Treatment of leg ulcers in sickle cell disease [letter] [published erratum appears in Blood 1990 Aug 1;76(3):654] [comment]

Blood ◽  
1990 ◽  
Vol 75 (12) ◽  
pp. 2467-2467 ◽  
Author(s):  
M Fried ◽  
J Golan ◽  
M] Moshe F$[corrected to Fried
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Leg Ulcers ◽  
Cell Disease

Long‐term hematologic and clinical outcomes of splenectomy in children with hereditary spherocytosis and sickle cell disease

2020 ◽  
Vol 67 (8) ◽  
Author(s):  
Bria J. Hall ◽  
Audra J. Reiter ◽  
Brian R. Englum ◽  
Jennifer A. Rothman ◽  
Henry E. Rice ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Clinical Outcomes ◽  
Sickle Cell ◽  
Hereditary Spherocytosis ◽  
Cell Disease
Sign in / Sign up

Export Citation Format

Share Document