Susceptible locus for obese type 2 diabetes mellitus in the 5′-flanking region of the tumor necrosis factor-α gene

2000 ◽  
Vol 55 (5) ◽  
pp. 449-452 ◽  
Author(s):  
S. Kamizono ◽  
K. Yamada ◽  
N. Seki ◽  
T. Higuchi ◽  
A. Kimura ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Flanking Region ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals The tumor necrosis factor-α gene polymorphism (-308g/a) in type 2 diabetes mellitus patients with tuberculosis infection

2019 ◽  
Vol 1317 ◽  
pp. 012035
Author(s):  
Mutiara Indah Sari ◽  
Milahayati Daulay ◽  
Tri Widyawati ◽  
Dwi Rita Anggraini ◽  
Dian Dwi Wahyuni ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Gene Polymorphism ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

Tumor necrosis factor α −238G>A genotype alters postprandial plasma levels of free fatty acids in obese individuals with type 2 diabetes mellitus

Metabolism ◽  
2007 ◽  
Vol 56 (5) ◽  
pp. 649-655 ◽  
Author(s):  
Bénédicte Fontaine-Bisson ◽  
Thomas M.S. Wolever ◽  
Jean-Louis Chiasson ◽  
Rémi Rabasa-Lhoret ◽  
Pierre Maheux ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Upregulation of Tumor Necrosis Factor-α-Induced Protein 8-Like 2 mRNA Is Negatively Correlated with Serum Concentrations of Tumor Necrosis Factor-α and Interleukin 6 in Type 2 Diabetes Mellitus

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Yongliang Liu ◽  
Xinmei Wang ◽  
Yan Zhao ◽  
Peiqing Zhao ◽  
Lianqing Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Healthy Controls ◽  
Factor Α ◽  
Necrosis Factor

Background. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a negative regulator of natural and adaptive immunity. The role of TIPE2 in type 2 diabetes mellitus (T2DM) remains unknown, although TIPE2 plays key roles in preserving inflammatory homeostasis. Methods. TIPE2 expression was measured by Western blotting and real-time polymerase chain reaction (RT-PCR) in peripheral blood mononuclear cells (PBMCs) isolated from T2DM patients and healthy controls, and tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and other related biometabolic parameters were detected using a nephelometer or by ELISA. Differentiated THP-1 cells were exposed to siTIPE2 and TIPE2 adenovirus. Results. TIPE2 was significantly increased in PBMCs from T2DM patients compared with those from healthy controls and was negatively correlated with serum TNF-α, IL-6, and hsCRP concentrations but positively correlated with HbA1c and LDL-C in T2DM patients. High glucose treatment (50 mmol/L) can upregulate the expression of TIPE2 and cytokine secretion in differentiated THP-1 cells. siTIPE2 infection exacerbated the increased TNF-α and IL-6 concentrations in differentiated THP-1 cells under high glucose conditions (50 mmol/L), while infection with TIPE2 adenovirus reversed the increased TNF-α concentration. Conclusions. The present study indicates that TIPE2 may participate in T2DM by regulating TNF-α production.

scholarly journals Tumor necrosis factor-α, interleukin-4 and -6 in the serum of health, chronic periodontitis, and type 2 diabetes mellitus

2016 ◽  
Vol 20 (5) ◽  
pp. 509 ◽  
Author(s):  
AnirudhBalakrishna Acharya ◽  
Srinath Thakur ◽  
MahadevayyaVeerayya Muddapur ◽  
RaghavendraDhirendra Kulkarni
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 4 ◽  
Factor Α ◽  
Necrosis Factor

Relationship between serum tumor necrosis factor-α and insulin resistance in obese men with Type 2 diabetes mellitus

2001 ◽  
Vol 52 (2) ◽  
pp. 119-123 ◽  
Author(s):  
Yasuo Mishima ◽  
Ayako Kuyama ◽  
Atsuhiko Tada ◽  
Kiyoshi Takahashi ◽  
Tatsuji Ishioka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor ◽  
Serum Tumor Necrosis
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