The effect of dopexamine on regional tissue oxygenation, systemic inflammation and amino acid exchange in major abdominal surgery

2000 ◽  
Vol 44 (5) ◽  
pp. 564-570 ◽  
Author(s):  
R. T. Suojaranta-Ylinen ◽  
E. T. Ruokonen ◽  
J. A. Takala
Keyword(s):  
Amino Acid ◽  
Abdominal Surgery ◽  
Systemic Inflammation ◽  
Tissue Oxygenation ◽  
Major Abdominal Surgery ◽  
Amino Acid Exchange ◽  
Acid Exchange

Increased plasma plant sterol concentrations and a heterozygous amino acid exchange in ATP binding cassette transporter ABCG5: A case report

2011 ◽  
Vol 54 (4) ◽  
pp. e458-e460 ◽  
Author(s):  
Sylvia Keller ◽  
Danielle Prechtl ◽  
Charalampos Aslanidis ◽  
Uta Ceglarek ◽  
Joachim Thiery ◽  
...  
Keyword(s):  
Case Report ◽  
Amino Acid ◽  
Plant Sterol ◽  
Atp Binding ◽  
Amino Acid Exchange ◽  
Atp Binding Cassette Transporter ◽  
Acid Exchange ◽  
Plasma Plant ◽  
Atp Binding Cassette

scholarly journals Collapse of the native structure caused by a single amino acid exchange in human NAD (P)H:quinone oxidoreductase 1

FEBS Journal ◽  
2014 ◽  
Vol 281 (20) ◽  
pp. 4691-4704 ◽  
Author(s):  
Wolf‐Dieter Lienhart ◽  
Venugopal Gudipati ◽  
Michael K. Uhl ◽  
Alexandra Binter ◽  
Sergio A. Pulido ◽  
...  
Keyword(s):  
Amino Acid ◽  
Single Amino Acid ◽  
Native Structure ◽  
Amino Acid Exchange ◽  
Acid Exchange

Apical and basolateral 4F2hc and the amino acid exchange of L-DOPA in renal LLC-PK1 cells

Amino Acids ◽  
2005 ◽  
Vol 29 (3) ◽  
pp. 213-219 ◽  
Author(s):  
P. Soares-da-Silva ◽  
M. P. Serrão
Keyword(s):  
Amino Acid ◽  
Amino Acid Exchange ◽  
Acid Exchange

scholarly journals Integration of computational modeling with membrane transport studies reveals new insights into amino acid exchange transport mechanisms

2015 ◽  
Vol 29 (6) ◽  
pp. 2583-2594 ◽  
Author(s):  
Kate L. Widdows ◽  
Nuttanont Panitchob ◽  
Ian P. Crocker ◽  
Colin P. Please ◽  
Mark A. Hanson ◽  
...  
Keyword(s):  
Amino Acid ◽  
Computational Modeling ◽  
Membrane Transport ◽  
Transport Mechanisms ◽  
Amino Acid Exchange ◽  
Transport Studies ◽  
Acid Exchange

scholarly journals Impact of Capsid Conformation and Rep-Capsid Interactions on Adeno-Associated Virus Type 2 Genome Packaging

2006 ◽  
Vol 80 (2) ◽  
pp. 810-820 ◽  
Author(s):  
Svenja Bleker ◽  
Michael Pawlita ◽  
Jürgen A. Kleinschmidt
Keyword(s):  
Amino Acid ◽  
Capsid Protein ◽  
Amino Acid Exchange ◽  
Genome Packaging ◽  
Adeno Associated Virus ◽  
Rep Proteins ◽  
Axes Of Symmetry ◽  
Conserved Amino Acids ◽  
Acid Exchange

ABSTRACT Single-stranded genomes of adeno-associated virus (AAV) are packaged into preformed capsids. It has been proposed that packaging is initiated by interaction of genome-bound Rep proteins to the capsid, thereby targeting the genome to the portal of encapsidation. Here we describe a panel of mutants with amino acid exchanges in the pores at the fivefold axes of symmetry on AAV2 capsids with reduced packaging and reduced Rep-capsid interaction. Mutation of two threonines at the rim of the fivefold pore nearly completely abolished Rep-capsid interaction and packaging. This suggests a Rep-binding site at the highly conserved amino acids at or close to the pores formed by the capsid protein pentamers. A different mutant (P. Wu, W. Xiao, T. Conlon, J. Hughes, M. Agbandje-McKenna, T. Ferkol, T. Flotte, and N. Muzyczka, J. Virol. 74:8635-8647, 2000) with an amino acid exchange at the interface of capsid protein pentamers led to a complete block of DNA encapsidation. Analysis of the capsid conformation of this mutant revealed that the pores at the fivefold axes were occupied by VP1/VP2 N termini, thereby preventing DNA introduction into the capsid. Nevertheless, the corresponding capsids had more Rep proteins bound than wild-type AAV, showing that correct Rep interaction with the capsid depends on a defined capsid conformation. Both mutant types together support the conclusion that the pores at the fivefold symmetry axes are involved in genome packaging and that capsid conformation-dependent Rep-capsid interactions play an essential role in the packaging process.

The pattern of amino acid exchange across the brain is unaffected by intravenous glutamine supplementation in head trauma patients

2008 ◽  
Vol 27 (6) ◽  
pp. 816-821 ◽  
Author(s):  
Agneta Berg ◽  
Bo Michael Bellander ◽  
Michael Wanecek ◽  
Åke Norberg ◽  
Urban Ungerstedt ◽  
...  
Keyword(s):  
Amino Acid ◽  
Head Trauma ◽  
Glutamine Supplementation ◽  
Trauma Patients ◽  
Amino Acid Exchange ◽  
The Brain ◽  
Acid Exchange

scholarly journals Renal metabolism of amino acids: its role in interorgan amino acid exchange

2004 ◽  
Vol 79 (2) ◽  
pp. 185-197 ◽  
Author(s):  
Marcel CG van de Poll ◽  
Peter B Soeters ◽  
Nicolaas EP Deutz ◽  
Kenneth CH Fearon ◽  
Cornelis HC Dejong
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Exchange ◽  
Renal Metabolism ◽  
Acid Exchange

Emergence of canine distemper in Bavarian wildlife associated with a specific amino acid exchange in the haemagglutinin protein

2011 ◽  
Vol 187 (3) ◽  
pp. 399-401 ◽  
Author(s):  
Karin Sekulin ◽  
Angela Hafner-Marx ◽  
Jolanta Kolodziejek ◽  
Dirk Janik ◽  
Peter Schmidt ◽  
...  
Keyword(s):  
Amino Acid ◽  
Canine Distemper ◽  
Amino Acid Exchange ◽  
Specific Amino Acid ◽  
Acid Exchange
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