Induction of collagenase-2 (matrix metalloproteinase-8) gene expression by interleukin-1β in human gingival fibroblasts

2001 ◽  
Vol 36 (3) ◽  
pp. 153-159 ◽  
Author(s):  
M. Abe ◽  
K. Kawamoto ◽  
H. Okamoto ◽  
N. Horiuchi
Keyword(s):  
Gene Expression ◽  
Matrix Metalloproteinase ◽  
Human Gingival Fibroblasts ◽  
Interleukin 1Β ◽  
Gingival Fibroblasts

Prostaglandin E2 Regulates Interleukin-1β-induced Matrix Metalloproteinase-3 Production in Human Gingival Fibroblasts

2004 ◽  
Vol 83 (3) ◽  
pp. 260-265 ◽  
Author(s):  
S.M.P.M. Ruwanpura ◽  
K. Noguchi ◽  
I. Ishikawa
Keyword(s):  
Matrix Metalloproteinase ◽  
Periodontal Disease ◽  
Prostaglandin E2 ◽  
Healthy Subjects ◽  
Human Gingival Fibroblasts ◽  
Interleukin 1Β ◽  
Prostaglandin E ◽  
Gingival Fibroblasts ◽  
Matrix Metalloproteinase 3 ◽  
Biological Actions

Prostaglandin E2 (PGE2) exerts its biological actions via EP receptors (EP1, EP2, EP3, and EP4). In the present study, we investigated whether PGE2 regulated interleukin (IL)-1β-induced matrix metalloproteinase (MMP)-3 production in human gingival fibroblasts (HGF) derived from periodontally healthy subjects and diseased patients. In HGF from healthy gingiva, PGE2 down-regulated IL-1β-induced MMP-3 production, whereas in HGF from periodontitis patients, PGE2 enhanced it. Butaprost (an EP2 agonist) and ONO-AE1-329 (an EP4 agonist) suppressed IL-1β-induced MMP-3 production, and 17-phenyl-ω-trinor PGE2 (an EP1 agonist) mimicked the PGE2 effect in HGF from healthy and periodontally diseased tissues, respectively. Analysis of these data suggests that, in HGF from healthy tissue, IL-1β-induced MMP-3 production is down-regulated by PGE2 via EP2 and EP4 receptors, whereas in cells from periodontally diseased tissue, IL-1β-induced MMP-3 production is up-regulated via EP1 receptors. Different regulation of IL-1β-induced MMP-3 production by PGE2 between healthy and periodontally diseased tissues may be involved in the pathogenesis of periodontal disease.

scholarly journals Effects of cleaning methods for custom abutment surfaces on gene expression of human gingival fibroblasts

2017 ◽  
Vol 59 (4) ◽  
pp. 533-539 ◽  
Author(s):  
Kazunori Nakajima ◽  
Tetsurou Odatsu ◽  
Ayano Shinohara ◽  
Koumei Baba ◽  
Yasuaki Shibata ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts ◽  
Cleaning Methods
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