scholarly journals Effect of Asiasarum Root Extract and Its Constituents on Interleukin-1β-Stimulated Matrix Metalloproteinase-1 Secretion from Human Gingival Fibroblasts

2016 ◽  
Vol 39 (5) ◽  
pp. 823-831 ◽  
Author(s):  
Megumi Futamura-Masuda ◽  
Mami Yokota-Honda ◽  
Takuya Anraku ◽  
Kanae Nakanishi ◽  
Kazuya Murata ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Human Gingival Fibroblasts ◽  
Interleukin 1Β ◽  
Root Extract ◽  
Gingival Fibroblasts ◽  
Matrix Metalloproteinase 1

Upregulation of matrix metalloproteinase-1 production by prostaglandin F2alpha in human gingival fibroblasts

2001 ◽  
Vol 36 (5) ◽  
pp. 334-339 ◽  
Author(s):  
Kazuyuki Noguchi ◽  
Yumiko Tominaga ◽  
Kenji Matsushita ◽  
Yuichi Izumi ◽  
Hirahito Endo ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Human Gingival Fibroblasts ◽  
Gingival Fibroblasts ◽  
Prostaglandin F2alpha ◽  
Matrix Metalloproteinase 1

Prostaglandin E2 Regulates Interleukin-1β-induced Matrix Metalloproteinase-3 Production in Human Gingival Fibroblasts

2004 ◽  
Vol 83 (3) ◽  
pp. 260-265 ◽  
Author(s):  
S.M.P.M. Ruwanpura ◽  
K. Noguchi ◽  
I. Ishikawa
Keyword(s):  
Matrix Metalloproteinase ◽  
Periodontal Disease ◽  
Prostaglandin E2 ◽  
Healthy Subjects ◽  
Human Gingival Fibroblasts ◽  
Interleukin 1Β ◽  
Prostaglandin E ◽  
Gingival Fibroblasts ◽  
Matrix Metalloproteinase 3 ◽  
Biological Actions

Prostaglandin E2 (PGE2) exerts its biological actions via EP receptors (EP1, EP2, EP3, and EP4). In the present study, we investigated whether PGE2 regulated interleukin (IL)-1β-induced matrix metalloproteinase (MMP)-3 production in human gingival fibroblasts (HGF) derived from periodontally healthy subjects and diseased patients. In HGF from healthy gingiva, PGE2 down-regulated IL-1β-induced MMP-3 production, whereas in HGF from periodontitis patients, PGE2 enhanced it. Butaprost (an EP2 agonist) and ONO-AE1-329 (an EP4 agonist) suppressed IL-1β-induced MMP-3 production, and 17-phenyl-ω-trinor PGE2 (an EP1 agonist) mimicked the PGE2 effect in HGF from healthy and periodontally diseased tissues, respectively. Analysis of these data suggests that, in HGF from healthy tissue, IL-1β-induced MMP-3 production is down-regulated by PGE2 via EP2 and EP4 receptors, whereas in cells from periodontally diseased tissue, IL-1β-induced MMP-3 production is up-regulated via EP1 receptors. Different regulation of IL-1β-induced MMP-3 production by PGE2 between healthy and periodontally diseased tissues may be involved in the pathogenesis of periodontal disease.

Sign in / Sign up

Export Citation Format

Share Document