The pain management in oncologic patients requires a multidisciplinary approach. Considering bone metastases, multiple myeloma and lymphoma, percutaneous procedures like vertebroplasty can provide rapid pain relief. However, percutaneous vertebroplasty must be placed in order to not delay systemic therapy or other modalities of treatment. In this article, we described our 15 years’ experience in collaborating with a multidisciplinary team, reviewing literature and special issues percutaneous vertebroplasty for spinal tumoral fractures.