Male and female sexual behavior potential of male rats prenatally exposed to the influence of alcohol, stress, or both factors.

1994 ◽  
Vol 108 (6) ◽  
pp. 1188-1195 ◽  
Author(s):  
Ingeborg L. Ward ◽  
O. Byron Ward ◽  
Robert J. Winn ◽  
Dawn Bielawski
2013 ◽  
pp. S99-S108 ◽  
Author(s):  
R. ŠLAMBEROVÁ ◽  
E. MACÚCHOVÁ ◽  
K. NOHEJLOVÁ-DEYKUN ◽  
B. SCHUTOVÁ ◽  
L. HRUBÁ ◽  
...  

The aim of the present study was to compare the response to acute application of several drugs in adult male and female rats prenatally exposed to methamphetamine (MA). Spontaneous locomotor activity and exploratory behavior of adult male and female rats prenatally exposed to MA (5 mg/kg) or saline were tested in a Laboras apparatus (Metris B.V., Netherlands) for 1 h. Challenge dose of the examined drug [amphetamine – 5 mg/kg; cocaine – 5mg/kg; MDMA (3,4-methylenedioxymethamphetamine) – 5 mg/kg; morphine – 5 mg/kg; THC (delta9-tetrahydrocannabinol) – 2 mg/kg] or saline was injected prior to testing. Our data demonstrate that prenatal MA exposure did not affect behavior in male rats with cocaine or morphine treatment, but increased locomotion and exploration in females. Application of amphetamine and MDMA in adulthood increased activity in both sexes, while cocaine and THC only in female rats. Morphine, on the other hand, decreased the activity in the Laboras test in both sexes. As far as sex and estrous cycle is concerned, the present study shows that males were generally less active than females and also females in proestrus-estrus phase of the estrous cycle were more active than females in diestrus. In conclusion, the present study shows that the prenatal MA exposure does not induce general sensitization but affects the sensitivity to drugs dependently to mechanism of drug action and with respect to gonadal hormones.


1992 ◽  
Vol 652 (1) ◽  
pp. 180-193 ◽  
Author(s):  
ROSSANA ARLETTI ◽  
AUGUSTA BENELLI ◽  
ALFIO BERTOLINI

1986 ◽  
Vol 69 (2) ◽  
pp. 188-191 ◽  
Author(s):  
P. Södersten ◽  
G.J. Boer ◽  
G.J. De Vries ◽  
R.M. Buijs ◽  
P. Melin

1973 ◽  
Vol 4 (1-2) ◽  
pp. 129-141 ◽  
Author(s):  
Carol Sue Carter ◽  
Sharon J Michael ◽  
Alan H Morris

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