For years, behavioral scientists have been examining the process of coping with life-threatening illnesses. In fact, much of the work in this area has been influenced by cognitive-behavioral theories (e.g., Lazarus & Folkman, 1984). The purpose of this article is to apply Beck’s model of cognitive therapy to coping, to discuss specific cognitive processes related to life-threatening illnesses, and to suggest specific interventions appropriate for individuals diagnosed with life-threatening illnesses. AIDS, cancer, and myocardial infarction are discussed in terms of the emotional reactions they may produce (e.g., anxiety, depression, and anger). Cognitive processes related to these emotions are examined and cognitive therapy techniques are suggested for helping individuals with maladaptive emotional and behavioral coping responses.