Cyberspace possesses unique characteristics, which should be taken into consideration in order to ensure the success of cyber operations or joint operations. How can the unique characteristics be addressed in strategic decision making? How can relatively more effective and efficient courses of action be selected or generated in cyberspace within a short period of time? These questions need to be addressed. This chapter briefly discusses the key requirements for strategic decision making. After a discussion about the key unique characteristics of cyberspace, it reveals the challenges that traditional strategic decision-making models are facing. Based on this analysis, this chapter proposes a new strategic decision-making framework in cyberspace, which helps to select or generate relatively more effective and efficient courses of action for a specific environment within a short period of time, thus guaranteeing the success in missions.