Supplemental Material for What Is in a Word? No Versus Yes Differentially Engage the Lateral Orbitofrontal Cortex

Theories of orbitofrontal cortex (OFC) function have evolved substantially over the last few decades. There is now a general consensus that the OFC is important for predicting aspects of future events and for using these predictions to guide behavior. Yet the precise content of these predictions and the degree to which OFC contributes to agency contingent upon them has become contentious, with several plausible theories advocating different answers to these questions. In this review we will focus on three of these ideas - the economic value, credit assignment, and cognitive map hypotheses – describing both their successes and failures. We will propose that these failures hint at a more nuanced role for the OFC in supporting the proposed functions when an underlying model or map of the causal structures in the environment must be constructed or updated.

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Faculty Opinions recommendation of Orbitofrontal cortex encodes willingness to pay in everyday economic transactions.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1090841.544176 ◽

2007 ◽

Author(s):

Kent Berridge

Keyword(s):

Willingness To Pay ◽

Orbitofrontal Cortex

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Faculty Opinions recommendation of Orbitofrontal cortex neurons as a common target for classic and glutamatergic antipsychotic drugs.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1137845.594930 ◽

2008 ◽

Author(s):

Guoping Feng ◽

Jonathan Ting

Keyword(s):

Orbitofrontal Cortex ◽

Antipsychotic Drugs ◽

Common Target

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Faculty Opinions recommendation of Different time courses for learning-related changes in amygdala and orbitofrontal cortex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13484096.14861224 ◽

2012 ◽

Author(s):

Andrew Bell

Keyword(s):

Orbitofrontal Cortex ◽

Time Courses

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Faculty Opinions recommendation of Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717547804.792952807 ◽

2012 ◽

Author(s):

Brian Baldo

Keyword(s):

Nucleus Accumbens ◽

Alcohol Consumption ◽

Orbitofrontal Cortex ◽

Endogenous Opioid

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Faculty Opinions recommendation of Neural estimates of imagined outcomes in the orbitofrontal cortex drive behavior and learning.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718149132.793486635 ◽

2013 ◽

Author(s):

Paul Fletcher ◽

Phil Corlett

Keyword(s):

Orbitofrontal Cortex

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The Orbitofrontal Cortex

10.1093/oso/9780198845997.001.0001 ◽

2019 ◽

Cited By ~ 12

Author(s):

Edmund T. Rolls

Keyword(s):

Bipolar Disorder ◽

Human Brain ◽

Obsessive Compulsive Disorder ◽

Orbitofrontal Cortex ◽

Multidisciplinary Approach ◽

Animal Behaviour ◽

Obsessive Compulsive ◽

Undergraduate Level ◽

Compulsive Disorder

The book will be valuable for those in the fields of neuroscience, neurology, psychology, psychiatry, biology, animal behaviour, economics, and philosophy, from the undergraduate level upwards. The book is unique in providing a coherent multidisciplinary approach to understanding the functions of one of the most interesting regions of the human brain, in both health and in disease, including depression, bipolar disorder, autism, and obsessive-compulsive disorder. There is no competing book published in the last 10 years.

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