scholarly journals A critical role of nucleus accumbens dopamine D1-family receptors in renewal of alcohol seeking after punishment-imposed abstinence.

2015 ◽  
Vol 129 (3) ◽  
pp. 281-291 ◽  
Author(s):  
Nathan J. Marchant ◽  
Konstantin Kaganovsky
Keyword(s):  
Nucleus Accumbens ◽  
Critical Role ◽  
Alcohol Seeking

Decreases in rat locomotor activity as a result of changes in synaptic transmission to neurons within the mesencephalic locomotor region

1993 ◽  
Vol 71 (5-6) ◽  
pp. 394-406 ◽  
Author(s):  
Stefan M. Brudzynski ◽  
Michael Wu ◽  
Gordon J. Mogenson
Keyword(s):  
Nucleus Accumbens ◽  
Synaptic Transmission ◽  
Synaptic Input ◽  
Cobalt Chloride ◽  
Critical Role ◽  
Ventral Pallidum ◽  
Functional Region ◽  
Mesencephalic Locomotor Region ◽  
Freely Behaving

The mesencephalic locomotor region is defined as a functional region sending signals to the spinal cord generators of rhythmical limb movements for locomotion. It has been shown that the mesencephalic locomotor region plays a critical role in locomotion initiated from the nucleus accumbens or from the subpallidal region. However, there are conflicting data on whether synaptic input from the nucleus accumbens – subpallidal region to the mesencephalic locomotor region mediates locomotion. The purpose of the study was to determine the role of synaptic input to different subregions of the mesencephalic locomotor region in locomotion induced by injecting dopamine into the nucleus accumbens or by injecting picrotoxin into the subpallidal region in freely behaving rats. Synaptic transmission in the mesencephalic locomotor region was eliminated by excitotoxic lesions or was reversibly interrupted by injecting cobalt chloride, which can block synaptic transmission. Excitotoxic lesions or injections of cobalt into subregions of the mesencephalic locomotor region significantly decreased, although did not completely block, locomotion. The most effective sites for cobalt- and lesion-induced reduction in locomotion were consistent with localization of the mesencephalic locomotor region. Effective sites for cobalt and lesions markedly overlapped but were not identical. The results indicate that synaptic transmission within the mesencephalic locomotor region contributes to dopamine- or picrotoxin-induced locomotion.Key words: locomotion, mesencephalic locomotor region, nucleus accumbens, ventral pallidum, dopamine, picrotoxin, excitotoxins, cobalt chloride.

scholarly journals A Critical Role of Lateral Hypothalamus in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence

2014 ◽  
Vol 34 (22) ◽  
pp. 7447-7457 ◽  
Author(s):  
N. J. Marchant ◽  
R. Rabei ◽  
K. Kaganovsky ◽  
D. Caprioli ◽  
J. M. Bossert ◽  
...  
Keyword(s):  
Lateral Hypothalamus ◽  
Critical Role ◽  
Alcohol Seeking

scholarly journals A Critical Role of Basolateral Amygdala–to–Nucleus Accumbens Projection in Sleep Regulation of Reward Seeking

2020 ◽  
Vol 87 (11) ◽  
pp. 954-966 ◽  
Author(s):  
Yao Wang ◽  
Zheng Liu ◽  
Li Cai ◽  
Rong Guo ◽  
Yan Dong ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Basolateral Amygdala ◽  
Critical Role ◽  
Sleep Regulation ◽  
Reward Seeking

Orexin-1 receptor signaling within the lateral hypothalamus, but not bed nucleus of the stria terminalis, mediates context-induced relapse to alcohol seeking

2020 ◽  
Vol 34 (11) ◽  
pp. 1261-1270
Author(s):  
Erin J Campbell ◽  
Mitchell KRI Hill ◽  
Xavier J Maddern ◽  
Shubo Jin ◽  
Terence Y Pang ◽  
...  
Keyword(s):  
Lateral Hypothalamus ◽  
Critical Role ◽  
Stria Terminalis ◽  
Receptor Signaling ◽  
Receptor System ◽  
Receptor Antagonism ◽  
Bed Nucleus ◽  
Seeking Behavior ◽  
Alcohol Seeking

Background: The lateral hypothalamic orexin (hypocretin) system has a well-established role in the motivation for reward. This has particular relevance to substance use disorders since orexin-1 receptors play a critical role in alcohol-seeking behavior, acting at multiple nodes in relapse-associated networks. Aims: This study aimed to further our understanding of the role of orexin-1 receptor signaling within the lateral hypothalamus and bed nucleus of the stria terminalis, specifically in context-induced relapse to alcohol-seeking following punishment-imposed abstinence. Methods: We trained inbred male alcohol-preferring rats to self-administer alcohol in one environment or context (Context A) and subsequently punished their alcohol-reinforced lever presses in a different environment (Context B) using contingent foot shock punishment. Finally, we tested rats for relapse-like behavior in either context following systemic, intra-lateral hypothalamus or intra-bed nucleus of the stria terminalis orexin-1 receptor antagonism with SB-334867. Results/outcomes: We found that systemic orexin-1 receptor antagonism significantly reduced alcohol-seeking in both contexts. Intra-lateral hypothalamus orexin-1 receptor antagonism significantly reduced alcohol-seeking in Context A whereas intra-bed nucleus of the stria terminalis orexin-1 receptor antagonism had no effect on alcohol-seeking behavior. Conclusions/interpretation: Our results suggest a role for the orexin-1 receptor system in context-induced relapse to alcohol-seeking. Specifically, intra-lateral hypothalamus orexin microcircuits contribute to alcohol-seeking.

Role of melanin-concentrating hormone in the nucleus accumbens shell in rats behaviourally sensitized to methamphetamine

2013 ◽  
Vol 16 (8) ◽  
pp. 1767-1780 ◽  
Author(s):  
Li-li Sun ◽  
Yan Zhang ◽  
Jian-feng Liu ◽  
Jun Wang ◽  
Wei-li Zhu ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopaminergic System ◽  
Critical Role ◽  
Locomotor Sensitization ◽  
Nucleus Accumbens Shell ◽  
Erk Phosphorylation ◽  
Melanin Concentrating Hormone ◽  
Erk Activity ◽  
The Brain

Abstract Melanin-concentrating hormone (MCH) is a neuropeptide and its receptor is extensively expressed throughout the brain. MCH has been suggested to regulate the rewarding and reinforcing effects of psychostimulants by potentiating the dopaminergic system within the midbrain. Moreover, MCH and its receptor can regulate ERK activity. The present study investigated the role of MCH in the nucleus accumbens (NAc) in rats behaviourally sensitized to methamphetamine (Meth). We found that the development of Meth-induced locomotor sensitization was attenuated by MCH infused into the NAc shell but not core. Moreover, the elevation of ERK phosphorylation in the NAc shell induced by Meth was inhibited by locally infused MCH. Infusion of the MCH receptor 1 (MCHR1) antagonist SNAP 94847 into the NAc shell but not core augmented the initiation of locomotor sensitization and amplitude of elevated phosphorylated ERK levels induced by Meth. The expression of Meth-induced locomotor sensitization and ERK alterations after 1 wk withdrawal were not affected by either MCH or SNAP 94847 infused into the NAc shell or core. These results indicate that MCH in the NAc shell plays a critical role in the development but not expression of Meth-induced locomotor sensitization in rats, which might be mediated by the ERK signalling pathway. Our study suggests that MCH might be a potential target for the treatment of Meth addiction.

scholarly journals Dopaminergic Projections From the Ventral Tegmental Area to the Nucleus Accumbens Modulate Sevoflurane Anesthesia in Mice

2021 ◽  
Vol 15 ◽  
Author(s):  
Huan Gui ◽  
Chengxi Liu ◽  
Haifeng He ◽  
Jie Zhang ◽  
Hong Chen ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Critical Role ◽  
Sevoflurane Anesthesia ◽  
Loss Of Righting Reflex ◽  
Delta Band ◽  
Dopaminergic Pathway ◽  
Righting Reflex ◽  
Ventral Tegmental

The role of the dopaminergic pathway in general anesthesia and its potential mechanisms are still unknown. In this study, we usedc-Fos staining combined with calcium fiber photometry recording to explore the activity of ventral tegmental area (VTA) dopaminergic neurons(VTA-DA) and nucleus accumbens (NAc) neurons during sevoflurane anesthesia. A genetically encoded dopamine (DA) sensor was used to investigate thefunction of the NAc in sevoflurane anesthesia. Chemogenetics and optogenetics were used to explore the role of the VTA-DA in sevofluraneanesthesia. Electroencephalogram (EEG) spectra, time of loss of righting reflex (LORR) and recovery of righting reflex (RORR) were recorded asassessment indicators. We found that VTA-DA and NAc neurons were inhibited during the induction period and were activated during the recoveryperiod of sevoflurane anesthesia. The fluorescence signals of dopamine decreased in the induction of and increased in the emergence from sevoflurane anesthesia.Activation of VTA-DA and the VTADA-NAc pathway delayed the induction and facilitated the emergence accompanying with thereduction of delta band and the augmentation of the gamma band. These data demonstrate that VTA-DA neurons play a critical role in modulating sevofluraneanesthesia via the VTADA-NAc pathway.

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