Behavioral disruption of memory reconsolidation: From bench to bedside and back again.

AbstractThe majority of smokers relapse even after successfully quitting because of the craving to smoking after unexpectedly re-exposed to smoking-related cues. This conditioned craving is mediated by reward memories that are frequently experienced and stubbornly resistant to treatment. Reconsolidation theory posits that well-consolidated memories are destabilized after retrieval, and this process renders memories labile and vulnerable to amnestic intervention. This study tests the retrieval reconsolidation procedure to decrease nicotine craving among people who smoke. In this study, 52 male smokers received a single dose of propranolol (n = 27) or placebo (n = 25) before the reactivation of nicotine-associated memories to impair the reconsolidation process. Craving for smoking and neural activity in response to smoking-related cues served as primary outcomes. Functional magnetic resonance imaging was performed during the memory reconsolidation process. The disruption of reconsolidation by propranolol decreased craving for smoking. Reactivity of the postcentral gyrus in response to smoking-related cues also decreased in the propranolol group after the reconsolidation manipulation. Functional connectivity between the hippocampus and striatum was higher during memory reconsolidation in the propranolol group. Furthermore, the increase in coupling between the hippocampus and striatum positively correlated with the decrease in craving after the reconsolidation manipulation in the propranolol group. Propranolol administration before memory reactivation disrupted the reconsolidation of smoking-related memories in smokers by mediating brain regions that are involved in memory and reward processing. These findings demonstrate the noradrenergic regulation of memory reconsolidation in humans and suggest that adjunct propranolol administration can facilitate the treatment of nicotine dependence. The present study was pre-registered at ClinicalTrials.gov (registration no. ChiCTR1900024412).

Download Full-text

Changing Technology or Behavior? The Impacts of a Behavioral Disruption

Sustainability ◽

10.3390/su13115861 ◽

2021 ◽

Vol 13 (11) ◽

pp. 5861

Author(s):

Marianne Pedinotti-Castelle ◽

Pierre-Olivier Pineau ◽

Kathleen Vaillancourt ◽

Ben Amor

Keyword(s):

Energy Transition ◽

Energy System ◽

Behavior Changes ◽

Ghg Emission ◽

The North ◽

Behavioral Disruption ◽

Transportation Sector ◽

Key Factor ◽

Additional Costs

Transportation is a key factor in the fight against climate change. Consumer behavior changes in transportation are underrepresented in energy policies, even if they could be essential to achieve the fixed GHG emission reduction targets. To help quantify the role of behaviors in energy transition and their implications on the dynamics of an energy system, this study is conducted using the North American TIMES Energy Model, adapted to Quebec (Canada). A behavioral disruption scenario (an increase in carpooling) is introduced in the model’s transportation sector and is compared to a massive electrification scenario. Our results highlight the fact that a behavioral disruption can lead to the same GHG emission reductions (65%) by 2050 as an electrification policy, while alleviating different efforts (such as additional electrical capacity and additional costs) associated with massive electrification. Moreover, the results are sensitive to behavior-related parameters, such as social discount rates and car lifetimes.

Download Full-text