The effect of dopamine agonists on risk behavior in Parkinson's disease patients with and without impulse control disorder

2011 ◽  
Author(s):  
W. P. Van Den Wildenberg
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Risk Behavior ◽  
Impulse Control ◽  
Dopamine Agonists ◽  
Impulse Control Disorder

scholarly journals Dopamine and reward hypersensitivity in Parkinson’s disease with impulse control disorder

Brain ◽  
2020 ◽  
Vol 143 (8) ◽  
pp. 2502-2518
Author(s):  
Daniel S Drew ◽  
Kinan Muhammed ◽  
Fahd Baig ◽  
Mark Kelly ◽  
Youssuf Saleh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Dopamine Agonists ◽  
Impulse Control Disorders ◽  
Reward Sensitivity ◽  
Impulse Control Disorder ◽  
Dopaminergic Medication ◽  
Neuropsychiatric Complications ◽  
Pupillary Responses

Abstract Impulse control disorders in Parkinson’s disease are common neuropsychiatric complications associated with dopamine replacement therapy. Some patients treated with dopamine agonists develop pathological behaviours, such as gambling, compulsive eating, shopping, or disinhibited sexual behaviours, which can have a severe impact on their lives and that of their families. In this study we investigated whether hypersensitivity to reward might contribute to these pathological behaviours and how this is influenced by dopaminergic medication. We asked participants to shift their gaze to a visual target as quickly as possible, in order to obtain reward. Critically, the reward incentive on offer varied over trials. Motivational effects were indexed by pupillometry and saccadic velocity, and patients were tested ON and OFF dopaminergic medication, allowing us to measure the effect of dopaminergic medication changes on reward sensitivity. Twenty-three Parkinson’s disease patients with a history of impulse control disorders were compared to 26 patients without such behaviours, and 31 elderly healthy controls. Intriguingly, behavioural apathy was reported alongside impulsivity in the majority of patients with impulse control disorders. Individuals with impulse control disorders also exhibited heightened sensitivity to exogenous monetary rewards cues both ON and OFF (overnight withdrawal) dopamine medication, as indexed by pupillary dilation in anticipation of reward. Being OFF dopaminergic medication overnight did not modulate pupillary reward sensitivity in impulse control disorder patients, whereas in control patients reward sensitivity was significantly reduced when OFF dopamine. These effects were independent of cognitive impairment or total levodopa equivalent dose. Although dopamine agonist dose did modulate pupillary responses to reward, the pattern of results was replicated even when patients with impulse control disorders on dopamine agonists were excluded from the analysis. The findings suggest that hypersensitivity to rewards might be a contributing factor to the development of impulse control disorders in Parkinson’s disease. However, there was no difference in reward sensitivity between patient groups when ON dopamine medication, suggesting that impulse control disorders may not emerge simply because of a direct effect of dopaminergic drug level on reward sensitivity. The pupillary reward sensitivity measure described here provides a means to differentiate, using a physiological measure, Parkinson’s disease patients with impulse control disorder from those who do not experience such symptoms. Moreover, follow-up of control patients indicated that increased pupillary modulation by reward can be predictive of the risk of future emergence of impulse control disorders and may thereby provide the potential for early identification of patients who are more likely to develop these symptoms.

Impulse control disorder and rapid eye movement sleep behavior disorder in Parkinson's disease

2014 ◽  
Vol 20 (12) ◽  
pp. 1411-1414 ◽  
Author(s):  
Sophie Bayard ◽  
Yves Dauvilliers ◽  
Huan Yu ◽  
Muriel Croisier-Langenier ◽  
Alexia Rossignol ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Eye Movement ◽  
Impulse Control ◽  
Behavior Disorder ◽  
Impulse Control Disorder ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
Sleep Behavior

scholarly journals Problematic Mobile Gaming in Parkinson's Disease: An Impulse Control Disorder for the Smartphone

2016 ◽  
Vol 4 (2) ◽  
pp. 277-278 ◽  
Author(s):  
Nicholas B. Galifianakis ◽  
Erica A. Byrd ◽  
Jill L. Ostrem ◽  
Caroline M. Tanner ◽  
Caroline A. Racine
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Impulse Control Disorder ◽  
Mobile Gaming

Parkinson's disease, impulse control disorder and the D3 dopamine receptor system: Preliminary PET imaging studies with [11C](+)PHNO comparison with [11C]racloride

NeuroImage ◽  
2010 ◽  
Vol 52 ◽  
pp. S84
Author(s):  
Isabelle Boileau ◽  
Mark Guttman ◽  
John R. Adams ◽  
Sylvain Houle ◽  
Junchao Tong ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopamine Receptor ◽  
Pet Imaging ◽  
Impulse Control ◽  
Impulse Control Disorder ◽  
Imaging Studies ◽  
Receptor System

scholarly journals Impulse control disorder in the patients of Parkinson’s disease: various correlations

2020 ◽  
Vol 6 (2) ◽  
pp. 87-91
Author(s):  
Anis Jukkarwala ◽  
◽  
Varun Gupta ◽  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Impulse Control Disorder

scholarly journals Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
S. Jesús ◽  
◽  
M. A. Labrador-Espinosa ◽  
A. D. Adarmes ◽  
C. Méndel-Del Barrio ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Dopamine Agonists ◽  
Rating Scale ◽  
Disease Onset ◽  
Impulse Control Disorders ◽  
Nonmotor Symptoms ◽  
Premorbid Personality ◽  
Validated Questionnaire

Abstract The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.

scholarly journals The urge to move in restless legs syndrome associated with Parkinson’s disease: A motor impulse control disorder?

2019 ◽  
Vol 405 ◽  
pp. 88
Author(s):  
A. Marques ◽  
L. Fantini ◽  
C. Lambert ◽  
B. Pereira ◽  
T. Vidal ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Restless Legs Syndrome ◽  
Impulse Control ◽  
Impulse Control Disorder ◽  
Restless Legs

Impulse control disorder in patients with Parkinson's disease under dopamine agonist therapy: a multicentre study

2014 ◽  
Vol 85 (8) ◽  
pp. 840-844 ◽  
Author(s):  
P. J. Garcia-Ruiz ◽  
J. C. Martinez Castrillo ◽  
A. Alonso-Canovas ◽  
A. Herranz Barcenas ◽  
L. Vela ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multicentre Study ◽  
Dopamine Agonist ◽  
Impulse Control ◽  
Impulse Control Disorder ◽  
Agonist Therapy ◽  
Dopamine Agonist Therapy

scholarly journals Impulse control disorder-linked hypersexuality complicated by disseminated gonococcal infection in a patient with Parkinson's disease

2020 ◽  
Vol 176 (4) ◽  
pp. 292-293 ◽  
Author(s):  
C. Moegle ◽  
A. Grillon ◽  
M. Anheim ◽  
D. Lipsker ◽  
C. Velter
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Impulse Control ◽  
Impulse Control Disorder ◽  
Gonococcal Infection
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