Effect of Ascorbic Acid on Skin Permeability in Adrenalectomized Rats

Nature ◽  
1951 ◽  
Vol 168 (4264) ◽  
pp. 119-120 ◽  
Author(s):  
BENGT H. PERSSON
Keyword(s):  
Ascorbic Acid ◽  
Skin Permeability ◽  
Adrenalectomized Rats

PITUITARY AND BLOOD CORTICOTROPHIN CHANGES IN ADRENALECTOMIZED RATS MAINTAINED ON PHYSIOLOGICAL DOSES OF CORTICOSTEROIDS

1962 ◽  
Vol 39 (1) ◽  
pp. 79-86 ◽  
Author(s):  
J. R. Hodges ◽  
Joan Vernikos-Danellis
Keyword(s):  
Ascorbic Acid ◽  
Pituitary Gland ◽  
Replacement Therapy ◽  
Daily Treatment ◽  
Mild Stress ◽  
Acid Control ◽  
Small Doses ◽  
Response To Stress ◽  
Adrenalectomized Rats

ABSTRACT Pituitary and blood corticotrophin (ACTH) concentrations were estimated in adrenalectomized rats maintained on cortisol or crude adrenocortical extract (ACE) with and without ascorbic acid. Blood ACTH levels were also determined in similarly treated animals after subjection to mild stress. Thirty days after adrenalectomy there were marked rises in pituitary and blood corticotrophin concentration which were prevented by daily treatment with small doses of cortisol or ACE. In contrast to intact animals, adrenalectomized rats exhibited markedly increased adrenocorticotrophic responses to mild stress. This pituitary hyperexcitability was not diminished by replacement therapy with corticoids alone but was considerably reduced by ascorbic acid given in conjunction with ACE. It is suggested that corticoids control the rate at which ACTH is synthesised in the pituitary gland and that other factors, including ascorbic acid, control the excitability of the pituitary gland in its adrenocorticotrophic response to stress.

FURTHER STUDIES ON THYROID - ADRENAL - ASCORBIC ACID RELATIONS IN ANIMALS EXPOSED TO COLD

1956 ◽  
Vol 34 (1) ◽  
pp. 1251-1260 ◽  
Author(s):  
André DesMarais
Keyword(s):  
Ascorbic Acid ◽  
Thyroid Hormones ◽  
Deleterious Effect ◽  
Low Doses ◽  
Growth And Survival ◽  
Beneficial Effects ◽  
Alarm Reaction ◽  
Different Doses ◽  
Adrenalectomized Rats

The effect of ascorbate administration on resistance to cold and thyroid function was studied in adrenalectomized rats receiving various amounts of cortisone and/or DCA; in thyroidectomized rats given different doses of of thyroxine, the effect of ascorbate administration was evaluated on both resistance to cold and adrenal function.In adrenalectomized rats given large doses of cortisone (2.5 mgm.) and exposed to cold, the administration of either ascorbate (150 mgm.) or DCA (2.5 mgm.) enhances the survival, reduces the extent of thymolysis, and decreases the activation of the thyroid. In adrenalectomized rats receiving no cortisone or DCA or low doses (0.4 and 0.1 mgm.) of these hormones, ascorbate administration (150 mgm.) still retains some of its beneficial effects on resistance to cold (better growth and survival); when low doses of DCA (0.1 mgm.) are given without cortisone, ascorbate administration seems to have a deleterious effect on the growth and survival during exposure to cold, with a greater increase in thyroid activity.In thyroidectomized rats exposed to cold, ascorbate administration (150 mgm.) has no effect in the absence of thyroxine, but increases the efficiency of low doses (3 μgm.) of thyroxine, preventing at the same time some of the typical signs of an alarm reaction: thymolysis and adrenal enlargement.These results are interpreted as showing that the role of the cortical hormones in resistance to cold might be limited to a "conditioning" action and that the beneficial effects of ascorbate administration would be mediated through the thyroid hormones.

FURTHER STUDIES ON THYROID - ADRENAL - ASCORBIC ACID RELATIONS IN ANIMALS EXPOSED TO COLD

1956 ◽  
Vol 34 (6) ◽  
pp. 1251-1260 ◽  
Author(s):  
André DesMarais
Keyword(s):  
Ascorbic Acid ◽  
Thyroid Hormones ◽  
Deleterious Effect ◽  
Low Doses ◽  
Growth And Survival ◽  
Beneficial Effects ◽  
Alarm Reaction ◽  
Different Doses ◽  
Adrenalectomized Rats

The effect of ascorbate administration on resistance to cold and thyroid function was studied in adrenalectomized rats receiving various amounts of cortisone and/or DCA; in thyroidectomized rats given different doses of of thyroxine, the effect of ascorbate administration was evaluated on both resistance to cold and adrenal function.In adrenalectomized rats given large doses of cortisone (2.5 mgm.) and exposed to cold, the administration of either ascorbate (150 mgm.) or DCA (2.5 mgm.) enhances the survival, reduces the extent of thymolysis, and decreases the activation of the thyroid. In adrenalectomized rats receiving no cortisone or DCA or low doses (0.4 and 0.1 mgm.) of these hormones, ascorbate administration (150 mgm.) still retains some of its beneficial effects on resistance to cold (better growth and survival); when low doses of DCA (0.1 mgm.) are given without cortisone, ascorbate administration seems to have a deleterious effect on the growth and survival during exposure to cold, with a greater increase in thyroid activity.In thyroidectomized rats exposed to cold, ascorbate administration (150 mgm.) has no effect in the absence of thyroxine, but increases the efficiency of low doses (3 μgm.) of thyroxine, preventing at the same time some of the typical signs of an alarm reaction: thymolysis and adrenal enlargement.These results are interpreted as showing that the role of the cortical hormones in resistance to cold might be limited to a "conditioning" action and that the beneficial effects of ascorbate administration would be mediated through the thyroid hormones.

Ascorbic acid metabolism in adrenalectomized rats

Metabolism ◽  
1971 ◽  
Vol 20 (11) ◽  
pp. 1036-1043 ◽  
Author(s):  
Mahesh G. Nathani ◽  
Idrees Bhai ◽  
N. Nath ◽  
H.F. Daginawala ◽  
M.C. Nath
Keyword(s):  
Ascorbic Acid ◽  
Acid Metabolism ◽  
Adrenalectomized Rats

Distribution of newly formed hepatic glycogen in adrenalectomized rats as observed by radioautography after injection of 3H-galactose

1984 ◽  
Vol 42 ◽  
pp. 228-229
Author(s):  
J. E. Michaels ◽  
J. T. Hung ◽  
E. L. Cardell ◽  
R. R. Cardell
Keyword(s):  
Glycogen Synthesis ◽  
Hepatic Glycogen ◽  
Electron Microscopic ◽  
Routine Procedures ◽  
Silver Grains ◽  
Synthetic Glucocorticoid ◽  
Adrenalectomized Rats

In order to study early events of glycogen synthesis, we have used adrenalectomized (ADX) rats fasted overnight and injected with the synthetic glucocorticoid dexamethasone (DEX) to stimulate glycogen synthesis. Rats were given DEX 0-5 hr prior to sacrifice and injected with 2 mCi 3H-galactose 1 hr prior to sacrifice. Liver was prepared for light (LM) and electron microscopic (EM) radioautography by routine procedures.The concentration of silver grains over hepatic cytoplasm was measured in LM radioautographs using a Zeiss Videoplan. The hepatocytes were categorized as unlabeled if no silver grains (gr) were present, lightly labeled (<10gr/100 μm2 cytoplasm) or intensely labeled (>10 gr/1002 μm cytoplasm). Although very few hepatocytes showed heavy labeling after 1 hr treatment with DEX, by 2 hr after DEX treatment 8% of the cells distributed throughout the lobule were intensely labeled.

Comparative Study of Ascorbic Acid Levels in Gastric Secretion, Blood, Urine and Saliva

1951 ◽  
Vol 18 (2) ◽  
pp. 224-229 ◽  
Author(s):  
Joseph T. Freeman ◽  
Roberta Hafkesbring
Keyword(s):  
Ascorbic Acid ◽  
Gastric Secretion ◽  
Comparative Study
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