A lymphocyte-inhibiting factor isolated from normal human liver

Nature ◽  
1974 ◽  
Vol 251 (5476) ◽  
pp. 655-656 ◽  
Author(s):  
KURT SCHUMACHER ◽  
GISEALA MAERKER-ALZER ◽  
URSEL WEHMER
2009 ◽  
Vol 18 (10) ◽  
pp. 1417-1422 ◽  
Author(s):  
Katalin Dezső ◽  
Sándor Paku ◽  
Veronika Papp ◽  
Eszter Turányi ◽  
Peter Nagy

Biochemistry ◽  
1990 ◽  
Vol 29 (12) ◽  
pp. 3030-3039 ◽  
Author(s):  
Katsuko Yamashita ◽  
Koji Inui ◽  
Kazuhide Totani ◽  
Naohisa Kochibe ◽  
Masumi Furukawa ◽  
...  

2018 ◽  
Vol 120 (5) ◽  
pp. 7907-7917 ◽  
Author(s):  
Paolo Fais ◽  
Martina Leopizzi ◽  
Valeria Di Maio ◽  
Lucia Longo ◽  
Carlo Della Rocca ◽  
...  

10.4081/965 ◽  
2009 ◽  
Vol 49 (4) ◽  
pp. 371 ◽  
Author(s):  
D Fanni ◽  
L Pilloni ◽  
S Orrù ◽  
P Coni

1980 ◽  
Vol 58 (6) ◽  
pp. 494-498 ◽  
Author(s):  
M. Pagé ◽  
J. Lagueux ◽  
C. Gauthier

We describe a method for the purification of normal human liver ferritin by ultrafiltration, gel filtration on Sephacryl S-300, and affinity chromatography on DEAE-Affi Gel Blue. The purity of the ferritin obtained was verified by immunoelectrophoresis, Ouchterlony immunodiffusion, polyacrylamide gel electrophoresis, and electrofocusing. This rapid method yields 32% of the original ferritin.


Toxins ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 164 ◽  
Author(s):  
Lv Chen ◽  
Shu Yang ◽  
Cong Wen ◽  
Shuilin Zheng ◽  
Yue Yang ◽  
...  

Microcystin-LR is a cyclic heptapeptide hepatotoxin produced by harmful cyanobacteria. A panel of microRNAs containing miR-451a were found to be significantly changed in normal human liver cells HL7702 after exposure to microcystin-LR (MC-LR) in our previous study. However, the functions of miR-451a in hepatotoxicity induced by MC-LR remained unclear. The study aimed to investigate the impacts of miR-451a in HL7702 cells following treatment with 5 or 10 μM MC-LR. The comet assay indicated that MC-LR can influence Olive tail moment (OTM) in HL7702 cells. Furthermore, increase of miR-451a significantly repressed DNA damage and the protein expression level of γ-H2AX induced by MC-LR. Moreover, over-expression of miR-451a inhibited the expression level of p-AKT1 protein in cells following treatment by MC-LR. These results showed that miR-451a may protect from MC-LR-induced DNA damage by down-regulating the expression of p-AKT1, which provides new clues for the diagnosis and therapy policies for liver damage induced by MC-LR.


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