Anti-thrombotic treatment enhances antibiotic efficiency in a humanized model of meningococcemia

Meningococcal infections remain particularly difficult to treat. Despite antibiotic therapy, the state of the patients often rapidly deteriorates. Early clinical studies suggest that meningococci acquire a form of resistance to antibiotic treatments during infections. Taking advantage of a humanized animal model of infection, we confirm that adherent bacteria become highly resistant to antibiotic treatments as early as 3-6 hours post infection, although fully sensitive in vitro. Within this time frame, meningococci adhere to the endothelium via their type IV pili, proliferate and eventually fill the vessel lumen. Using intravital imaging, we show that rapidly upon infection blood flow is dramatically decreased, thus limiting antibiotic access to infected vessels. Concomitantly, fibrin is deposited inside infected vessels in proximity to bacterial aggregates. Pharmacologically impairing thrombin generation by inhibiting Factor X activity not only improves blood flow in infected vessels, but also enhances the efficacy of the antibiotic treatment. Our results indicate that the combined administration of anticoagulants together with antibiotics might represent a therapeutic approach to treat meningococcal sepsis more efficiently.

The Implementation of Supervision of Madrasah Principal in Developing A Guidance and Counseling Program

The results of this study indicate that: 1) The implementation of the supervision of the madrasah principal in developing the guidance and counseling program has been well implemented and can help, guide, and provide direction to BK teachers in compiling and developing guidance and counseling programs. The steps are carried out in several steps, including preparing a schedule and supervision instrument, notifying the BK teacher who will be supervised, carrying out supervision to the BK teacher by checking the program and monitoring its implementation, and evaluating or assessing the BK program. The technique used in the implementation of the supervision of the madrasah principal is individual and group techniques. Meanwhile, the approach to the supervision of the head of the madrasah is a direct and indirect approach. 2) Factors supporting the implementation of the supervision of the madrasah Principal in developing guidance and counseling programs are cooperation and support from all parties in the school, the existence of a program or supervision schedule, and BK tools in the form of programs and RPL. While the inhibiting factor is the existence of an agenda or schedule for the madrasa principal that coincides with the schedule for the implementation of supervision for BK teachers so that supervision can be delayed. 3) The solution to overcome obstacles in implementing the supervision of the madrasa principal in developing a counseling guidance program is to arrange or change the supervision schedule to another time and coordinate with the BK teacher so that supervision can still be carried out.

Komunikasi Keluarga Penyintas Covid-19 di Pedesaan: (Studi Kasus Banyumas dan Cilacap)

The Covid-19 pandemic that has lasted for more than a year has changed many things. One thing that has changed is family communication, especially one whose members have been confirmed positive for Covid-19. This study aims to determine: 1) the communication patterns of the families of covid-19 survivors; 2) the supporting and inhibiting factors in healing psychological trauma due to Covid-19; and 3) the communication patterns of the survivors before, during, and after recovering from Covid-19. The research method used is a case study conducted in Sawitan Village, Banyumas Regency, and Rikmayung Village, Cilacap Regency. The study results show that: 1) family members are the prominent supporters of communication during survivors experiencing symptoms of Covid-19, and during the initial recovery period and socializing with the community; 2) the supporting factor for healing psychological trauma is family communication with a positive tone and good communication with neighbours and the environment, while the inhibiting factor is communication avoidance, and 3) Covid-19 survivors tend to communicate more empathy with other sufferers and are more careful in carrying out health protocols.

DIPLOMASI DIGITAL DAN IMPLEMENTASI APLIKASI SAFE TRAVEL DI KEMENTERIAN LUAR NEGERI

Public Service-Based Information Technology and Communication (ICT), Electronics Neighborhood/Pillars of Citizens (e-RT/RW) (Study of e-Government in Kelurahan Talang Semut Kecamatan Bukit Kecil Kota Palembang). This study is based on the new way to manage public sector-oriented management services to the community forward, rather than the interests of the government. E-Government Program is a program of e-RT/RW Surabaya. The results showed the program e-RT/RW sourced from Palembang Mayor Factors supporting the program e-RT/RW in the Kelurahan Talang Semut, Bukit Kecil, Palembang is the full support of the government and relevant parties, the basic service standards and infrastructure are qualified. Whereas the inhibiting factor is the public interest, a lack of internal party support, and lack of maintenance of infrastructure. From the research, the researchers suggest that the necessary socialization harder, but not merely socialization but also training to people to operate online. Transparent financial accountability. Holding intense communication forum, addition of website content, and control of technical problems with a thorough evaluation.

Non-Opioid Peptides Targeting Opioid Effects

Opioids are the most potent widely used analgesics, primarily, but not exclusively, in palliative care. However, they are associated with numerous side effects, such as tolerance, addiction, respiratory depression, and cardiovascular events. This, in turn, can result in their overuse in cases of addiction, the need for dose escalation in cases of developing tolerance, and the emergence of dose-related opioid toxicity, resulting in respiratory depression or cardiovascular problems that can even lead to unintentional death. Therefore, a very important challenge for researchers is to look for ways to counteract the side effects of opioids. The use of peptides and their related compounds, which have been shown to modulate the effects of opioids, may provide such an opportunity. This short review is a compendium of knowledge about the most important and recent findings regarding selected peptides and their modulatory effects on various opioid actions, including cardiovascular and respiratory responses. In addition to the peptides more commonly reported in the literature in the context of their pro- and/or anti-opioid activity—such as neuropeptide FF (NPFF), cholecystokinin (CCK), and melanocyte inhibiting factor (MIF)—we also included in the review nociceptin/orphanin (N/OFQ), ghrelin, oxytocin, endothelin, and venom peptides.

Implementation of the Andragogy Learning Model in Andragogy Competency Training for PKBM Tutors

This study aims to determine the implementation of the Andragogy Learning Model in Andragogy Competency Training for PKBM Tutors in Kampar Regency. The method used is descriptive qualitative. Researchers used observation, interviews and documentation. Sources of data are 2 tutors 5 students. The results showed that the implementation of the andragogy learning model was the delivery of material from the tutor/training instructor according to the material that had been mutually agreed upon, then there was a question and answer or discussion for joint evaluation. The results of the andragogy learning model showed that there was an increase and change in terms of knowledge, attitudes and skills. In knowledge knowing about andragogy competencies and how to apply them in adult learning. In attitude that the trainees are very good in attitude, behavior and activity so that enthusiasm in learning is very good. In terms of skills, participants have been able to practice in learning about andragogy competencies because they have in-depth understanding of andragogy competencies for tutors after training. The supporting factors are the enthusiasm of the participants, the focus of the participants, supported by PKBM Mutiara Kampar, the network between PKBM and tutors who are able to guide the participants well, and teach the material as expected. The inhibiting factor is the timing and delivery of materials that adapt to the understanding of the participants.

Implementation of java cultural education in elementary school in Yogyakarta

The purpose of the study was to describe the implementation of Javanese cultural education in elementary schools in Yogyakarta. The research method is a qualitative descriptive approach. Data collection techniques used field observation techniques, in-depth interviews, and documentation studies. Analysis of the data that has been collected is reduced and presented. Conclusions on the implementation of Javanese education and culture are as follows: (1). Implementation of the school's vision, mission and goals (2). Curriculum development in Javanese cultural education (3). Javanese cultural education learning (4). Habituation in Javanese cultural educators. Supporting factors are (a) good school background (b). Local government regulations support (c). Complete facilities and infrastructure (d) support from all school components (e). Good school management 6). Students come from Javanese society. Inhibiting factor (a). There are no expert instructors (b). There are no standard guidelines (c). Student interest is changing, (d). Lack of teachers in developing Javanese cultural education (e). Not maximal in utilizing learning media.

Accounting in Marketing Perspective Training Batch III, Sekolah Bisnis dan Manajemen – Institut Teknologi Bandung (SBM-ITB)

Managerial accounting is an activity or process that produces information that is useful for management for making economic decisions in carrying out management functions. Sekolah Binis dan Manajemen – Institut Teknologi Bandung (SBM-ITB) collaborated with the MarkPlus Institute to carry out the OMNI MBA Program 2020 Batch III on February 5, 2021. Out of the twelve subject topics contained in the program, one of them is entitled Accounting in Marketing Perspective that scheduled on Friday, 5 February 2021 with the author as the facilitator. The subjects include the Break-Even Point (BEP) theory, the Cost Classifications theory with the concept of Different Cost for Different Purposes, as well as related case studies. This training is expected to increase the competence and productivity of company managers in maximizing their role. This training went smoothly because of the strong enthusiasm of the participants. In addition, the inhibiting factor is the limited training time.

STRATEGI PENGEMBANGAN BADAN USAHA MILIK DESA (BUM Desa) DENGAN PENDEKATAN FORCE FIELD ANALYSIS

The purpose of this research is to analyze a BUM Desa development strategy in Lumajang Regency. The research was conducted at BUM Desa Labruk Lor according to recommendations from the Lumajang Regency Government of East Java Province. The business units managed by BUM Desa Labruk Lor are fisheries, trade, agriculture, and culinary tourism businesses. Data were analyzed using the FFA (Force Field Analysis) approach by considering the driving factors for the development of BUM Desa (D) and the factors inhibiting the development of BUM Desa (H). The results show that the driving factor (key) is having formal legality (Village Regulations and AD/ART) and the formation of management is carried out democratically, while the inhibiting factor (key) is that business activities are still limited to the provision of production facilities and marketing services for fish-based processed products of catfish. The conclusion of this research is that the value of the strength field is smaller than the field of weakness, so it requires certain efforts to develop BUM Desa Labruk Lor. The recommendation for the BUM Desa development strategy is by expanding the network of cooperation with suppliers of fishery production facilities and the use of information technology as a medium for processed marketing. Tujuan penelitian ini ialah menganalisis strategi pengembangan Badan Usaha Milik Desa (BUM Desa) di Kabupaten Lumajang. Penelitian dilakukan pada BUM Desa Labruk Lor sesuai rekomendasi dari Pemerintah Kabupaten Lumajang Provinsi Jawa Timur. Unit usaha yang dikelola BUM Desa Labruk Lor ialah usaha perikanan, perdagangan, pertanian, dan wisata kuliner. Data dianalisis menggunakan pendekatan FFA (Force Field Analysis) dengan mempertimbangkan faktor pendorong pengembangan BUM Desa dan faktor penghambat pengembangan BUM Desa. Hasil penelitian menunjukkan bahwa faktor pendorong (kunci) ialah memiliki legalitas formal (Peraturan Desa dan AD/ART) dan pembentukan kepengurusan dilakukan secara demokratis, sedangkan faktor penghambat (kunci) ialah kegiatan usaha masih terbatas pada pengadaan sarana produksi dan jasa pemasaran produk olahan berbasis ikan lele. Kesimpulan penelitian didapatkan bahwa nilai medan kekuatan lebih kecil jika dibandingkan dengan nilai medan kelemahan, sehingga membutuhkan upaya-upaya tertentu untuk pengembangan BUM Desa Labruk Lor. Rekomendasi strategi pengembangan BUM Desa dengan cara memperluas jaringan kerjasama dengan pemasok sarana produksi perikanan dan pemanfaatan teknologi informasi sebagai media pemasaran olahan.