Genetic regulation of glucose phosphate isomerase in mouse oocytes

The dimeric enzyme glucose phosphate isomerase (GPI-1) is regulated in oocytes by a cis-acting temporal gene (Gpi-1t) that maps close to the structural gene (Gpi-1s). Quantitative cellulose acetate electrophoresis of GPI-1 allozymes from unfertilized eggs produced by various Gpi-1sa / Gpi-1sb heterozygous females revealed a new Gpi-1t allele that we have designated Gpi-1tc. This allele is present in 101/H mice and a partially congenie stock that carries the Gpi-lsa gene derived from the AKR strain. We have confirmed that Gpi-1tc is closely linked to Gpi-1s and that it is cis-acting. It produces higher levels of GPI-1 in unfertilized eggs than the other two Gpi-lt alleles that are known (Gpi-1ta and Gpi-1tb) but has no effect on GPI-1 in somatic tissues or spermatozoa. This new Gpi-1t allele represents a third developmental programme for GPI-1 expression in oocytes.

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Cell-Free Translation of Messenger RNAs from Adult and Fetal Human Muscle. Characterization or Neosynthesized Glycogen Phosphorylase, Phosphofructokinase and Glucose Phosphate Isomerase

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1981.tb05293.x ◽

1981 ◽

Vol 116 (1) ◽

pp. 7-12 ◽

Cited By ~ 46

Author(s):

Axel KAHN ◽

Dominique COTTREAU ◽

Dominique DAEGELEN ◽

Jean-Claude DREYFUS

Keyword(s):

Glycogen Phosphorylase ◽

Human Muscle ◽

Messenger Rnas ◽

Glucose Phosphate Isomerase ◽

Glucose Phosphate ◽

Free Translation

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Characterization of the 5′ end of the gene for human glucose phosphate isomerase (GPI)

Genomics ◽

10.1016/0888-7543(90)90212-d ◽

1990 ◽

Vol 7 (4) ◽

pp. 638-643 ◽

Cited By ~ 12

Author(s):

James I.H. Walker ◽

Pelin Faik ◽

Michael J. Morgan

Keyword(s):

Glucose Phosphate Isomerase ◽

Glucose Phosphate

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Comparison of human and murine isolates of Schistosoma mansoni from Richard-Toll, Senegal, by isoelectric focusing

Journal of Helminthology ◽

10.1017/s0022149x00015868 ◽

1997 ◽

Vol 71 (2) ◽

pp. 175-181 ◽

Cited By ~ 7

Author(s):

M. Sène ◽

P. Brémond ◽

J.P. Hervé ◽

V.R. Southgate ◽

B. Sellin ◽

...

Keyword(s):

Genetic Variation ◽

Acid Phosphatase ◽

Lactate Dehydrogenase ◽

Schistosoma Mansoni ◽

Isoelectric Focusing ◽

Glucose Phosphate Isomerase ◽

Glucose Phosphate ◽

Enzyme Systems ◽

Glucose 6 Phosphate Dehydrogenase ◽

Arvicanthis Niloticus

AbstractStudies on human and murine isolates of Schistosoma mansoni, from Richard-Toll, Senegal, were carried out by isoelectric focusing in polyacrylamide gels. Seven enzyme systems; lactate dehydrogenase (LDH), malate dehydrogenase (MDH), glucose-6-phosphate dehydrogenase (G6PD), acid phosphatase (AcP), hexokinase (HK), glucose phosphate isomerase (GPI), and phosphoglucomutase (PGM), were used to compare the two isolates. All systems tested, apart from LDH, were found to be polymorphic for both isolates. Interestingly, one phenotype is more frequent than the remainder. The results show that there is no significant genetic variation between the S. mansoni isolates from man and the rodents, Arvicanthis niloticus and Mastomys huberti.

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