Growth induced by pulsatile infusion of an amidated fragment of human growth hormone releasing factor in normal and GHRF-deficient rats

Nature ◽  
1985 ◽  
Vol 314 (6008) ◽  
pp. 281-283 ◽  
Author(s):  
R. G. Clark ◽  
I. C. A. F. Robinson
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Growth Hormone Releasing Factor ◽  
Pulsatile Infusion

Periodic interactions of GH-releasing factor and somatostatin can augment GH release in vitro

1987 ◽  
Vol 253 (5) ◽  
pp. E508-E514
Author(s):  
J. Weiss ◽  
M. J. Cronin ◽  
M. O. Thorner
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Male Rat ◽  
Base Line ◽  
Additive Effects ◽  
Growth Hormone Releasing Factor ◽  
The Impact

Growth hormone (GH) is secreted as pulses in vivo. To understand the signals governing this periodicity, we have established a perifusion-based model of pulsatile GH release. Male rat anterior pituitaries were dispersed and perifused with pulses of human growth hormone-releasing factor-(1--40) (GHRF), with or without a continuous or discontinuous somatostatin tonus. An experiment was composed of a 1-h base-line collection followed by four 3-h cycles; each contained single or paired 10-min infusion(s) of 3 nM GHRF. In testing the impact of somatostatin, the protocol was identical except that 0.3 nM somatostatin was added 30 min into the base-line period and then was either continued throughout the study or withdrawn during the periods of GHRF infusion. GH base lines with somatostatin were lower than vehicle base lines (P less than 0.05). GHRF pulses generated consistent peaks of GH release between 200 and 300 ng. min-1. (10(7) cells)-1, and these peaks were not altered by continuous somatostatin. In contrast, withdrawal of somatostatin during GHRF administration elicited markedly higher GH peaks (P less than 0.05) and more total GH release (P less than 0.05). This response could not be accounted for by the additive effects of GHRF and somatostatin withdrawal.

Degradation of aspartic acid and asparagine residues in human growth hormone-releasing factor

2009 ◽  
Vol 39 (4) ◽  
pp. 364-374 ◽  
Author(s):  
JACOB BONGERS ◽  
EDGAR P. HEIMER ◽  
THEODORE LAMBROS ◽  
YU-CHING E. PAN ◽  
ROBERT M. CAMPBELL ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Aspartic Acid ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Growth Hormone Releasing Factor

scholarly journals Non-Clinical Pharmacology and Safety Evaluation of TH9507, a Human Growth Hormone-Releasing Factor Analogue

2007 ◽  
Vol 100 (1) ◽  
pp. 49-58 ◽  
Author(s):  
Eckhardt S. Ferdinandi ◽  
Paul Brazeau ◽  
Kim High ◽  
Bryan Procter ◽  
Stephen Fennell ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Clinical Pharmacology ◽  
Human Growth Hormone ◽  
Safety Evaluation ◽  
Human Growth ◽  
Growth Hormone Releasing Factor

Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth

Nature ◽  
1985 ◽  
Vol 315 (6018) ◽  
pp. 413-416 ◽  
Author(s):  
Robert E. Hammer ◽  
Ralph L. Brinster ◽  
Michael G. Rosenfeld ◽  
Ronald M. Evans ◽  
Kelly E. Mayo
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Human Growth Hormone ◽  
Somatic Growth ◽  
Human Growth ◽  
Growth Hormone Releasing Factor
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