Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies

10.1038/85520 ◽  
2001 ◽  
Vol 7 (3) ◽  
pp. 365-368 ◽  
Author(s):  
Werner Hoch ◽  
John McConville ◽  
Sigrun Helms ◽  
John Newsom-Davis ◽  
Arthur Melms ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Receptor Tyrosine Kinase ◽  
Receptor Antibodies

Coexistent of muscle specific tyrosine kinase and acetylcholine receptor antibodies in a myasthenia gravis patient

2010 ◽  
Vol 58 (4) ◽  
pp. 668 ◽  
Author(s):  
Madhuri Behari ◽  
Hamid Suhail ◽  
Subbiah Vivekanandhan ◽  
Sumit Singh
Keyword(s):  
Tyrosine Kinase ◽  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Receptor Antibodies

scholarly journals Simultaneous Presence of Acetylcholine Receptor and Muscle Specific Tyrosine Kinase Antibodies in Myasthenia Gravis

2019 ◽  
Vol 4 (4) ◽  
pp. 128-130
Author(s):  
Maryam Poursadeghfard ◽  
Sara Azhdari
Keyword(s):  
Neuromuscular Junction ◽  
Tyrosine Kinase ◽  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Receptor Tyrosine Kinase ◽  
Good Condition ◽  
Autoimmune Disorder ◽  
Simultaneous Presence ◽  
Specific Receptor ◽  
Progressive Course

Myasthenia gravis (MG) is known as an autoimmune disorder which affects transmission in neuromuscular junction. The serologic tests used for diagnosis include acetylcholine receptor and muscle specific receptor tyrosine kinase antibodies. Studies often have reported that patients with formal antibody are negative for the latter one. However, very limited studies have reported positive anti-muscle specific receptor tyrosine kinase antibody in a small percentage of patients with acetylcholine receptor antibody. Here, we reported a young woman who was diagnosed with MG and had a rapid and progressive course of the disease. She was seropositive for both acetylcholine receptor and muscle-specific receptor tyrosine kinase antibodies simultaneously. However, she discharged from the hospital with good condition after treatment.

Therapeutic Immunoadsorption of Acetylcholine Receptor Antibodies in Myasthenia Gravis

1988 ◽  
Vol 540 (1 Advances in N) ◽  
pp. 554-556 ◽  
Author(s):  
TAKESHI SATO ◽  
YASUNORI ISHIGAKI ◽  
TADATOSHI KOMIYA ◽  
HIROSHI TSUDA
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Receptor Antibodies

Subunit specificity of the acetylcholine receptor antibodies in double seropositive myasthenia gravis

2021 ◽  
Author(s):  
Vasiliki Zouvelou ◽  
Maria Michail ◽  
Maria Belimezi ◽  
Paraskevi Zisimopoulou
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Receptor Antibodies

scholarly journals Myasthenia gravis in children: analysis of 18 patients

2001 ◽  
Vol 59 (3B) ◽  
pp. 681-685 ◽  
Author(s):  
Maria da Penha A. Morita ◽  
Alberto A. Gabbai ◽  
Acary S.B. Oliveira ◽  
Audrey S. Penn
Keyword(s):  
Myasthenia Gravis ◽  
Intravenous Immunoglobulin ◽  
Acetylcholine Receptor ◽  
Nerve Stimulation ◽  
Chest Ct ◽  
Clinical Severity ◽  
Myasthenic Crisis ◽  
Repetitive Nerve Stimulation ◽  
Follicular Hyperplasia ◽  
Receptor Antibodies

Myasthenia gravis (MG) in childhood is rare comprising 10 to 20 % of all myasthenic patients. We studied 18 patients with MG whose first symptoms started from 1 to 12 years of age, followed at the Department of Neurology of the UNIFESP-EPM, from January 1983 to August 1997. There were 10 girls and 8 boys (1.2:1). Eleven patients (61%) presented moderate or severe generalized disease and 4 (22%) had at least one myasthenic crisis. EMG with supramaximal repetitive nerve stimulation was diagnostic in 8 (47%) out of 17 patients, and chest CT was normal in 14 patients. Seropositivity to acetylcholine receptor antibodies was found in 81.6% (9 out of 11 tested) and the levels had no relation to clinical severity. Nine out of 16 patients (56%) worsened with pyridostigmine alone and were treated with prednisone. Four out of those nine continued worsening despite steroids and were subjected to thymectomy (all showed thymic lymphoid follicular hyperplasia). Three patients (75%) improved markedly after thymectomy and one (25%) worsened, eventually getting better with intravenous immunoglobulin and oral azathioprine. MG treatment, using all resources available, has to be individualized for each child.

Acetylcholine Receptor Antibodies in Penicillamine-lnduced Myasthenia Gravis

JAMA ◽  
1981 ◽  
Vol 246 (17) ◽  
pp. 1901
Author(s):  
Tomas S. Bocanegra
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Receptor Antibodies

Binding properties and subclass distribution of anti-acetylcholine receptor antibodies in myasthenia gravis

1981 ◽  
Vol 1 (1) ◽  
pp. 125-135 ◽  
Author(s):  
Ann Kari Lefvert ◽  
Sylvia Cuénoud ◽  
Bernard W. Fulpius
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Binding Properties ◽  
Receptor Antibodies ◽  
Anti Acetylcholine

Serum Acetylcholine Receptor Antibodies Before the Clinical Onset of Myasthenia Gravis

2018 ◽  
Vol 5 (2) ◽  
pp. 261-264 ◽  
Author(s):  
Ellen Strijbos ◽  
Jan J.G.M. Verschuuren ◽  
Jan B.M. Kuks
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Clinical Onset ◽  
Receptor Antibodies

Serum acetylcholine receptor antibodies in diagnosis and therapy monitoring of myasthenia gravis

1980 ◽  
Vol 301 (2) ◽  
pp. 127-128 ◽  
Author(s):  
K. Heininger ◽  
A. Fateh-Moghadam ◽  
K. V. Toyka ◽  
U. A. Besinger ◽  
J. Witthöft
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Therapy Monitoring ◽  
Diagnosis And Therapy ◽  
Receptor Antibodies
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