scholarly journals Classical eyeblink conditioning using electrical stimulation of caudal mPFC as conditioned stimulus is dependent on cerebellar interpositus nucleus in guinea pigs

2012 ◽  
Vol 33 (6) ◽  
pp. 717-727 ◽  
Author(s):  
Guang-yan Wu ◽  
Juan Yao ◽  
Zheng-li Fan ◽  
Lang-qian Zhang ◽  
Xuan Li ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Conditioned Stimulus ◽  
Guinea Pigs ◽  
Eyeblink Conditioning ◽  
Interpositus Nucleus ◽  
Cerebellar Interpositus Nucleus ◽  
Stimulation Of

Transfer of classical eyeblink conditioning with electrical stimulation of mPFC or tone as conditioned stimulus in guinea pigs

2014 ◽  
Vol 274 ◽  
pp. 19-29 ◽  
Author(s):  
Juan Yao ◽  
Guang-yan Wu ◽  
Guo-long Liu ◽  
Shu-lei Liu ◽  
Yi Yang ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Conditioned Stimulus ◽  
Guinea Pigs ◽  
Eyeblink Conditioning ◽  
Stimulation Of

scholarly journals Trace eyeblink conditioning is associated with changes in synaptophysin immunoreactivity in the cerebellar interpositus nucleus in guinea pigs

2018 ◽  
Vol 38 (3) ◽  
Author(s):  
Rui Li ◽  
Qi Li ◽  
Xiao-Lei Chu ◽  
Tao Tao ◽  
Lan Li ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Guinea Pigs ◽  
Transmembrane Protein ◽  
Eyeblink Conditioning ◽  
Trace Conditioning ◽  
Interpositus Nucleus ◽  
Important Indicator ◽  
Cerebellar Interpositus Nucleus ◽  
Immunohistochemical Techniques ◽  
Trace Eyeblink Conditioning

Synaptic plasticity plays a role during trace eyeblink conditioning (TEBC). Synaptophysin (Syn) is a major integral transmembrane protein, located particularly in the synaptic vesicles, and is considered a molecular marker of synapses. In addition, Syn immunoreactivity is an important indicator of synaptic plasticity. In the present study, we used immunohistochemical techniques to assess changes in Syn expression in the cerebellar interpositus nucleus (IN) of guinea pigs exposed to TEBC and pseudoconditioning. Additionally, we analyzed the relationship between Syn immunoreactivity and the percentage of trace-conditioned responses. Guinea pigs underwent trace conditioning or pseudoconditioning. Following two, six, or ten sessions, they were perfused and the cerebellum was removed for Syn immunohistochemical evaluation. After sessions 6 and 10, a significant increase in conditioned response (CR) percentage was observed in the trace-conditioned group, with the CR percentage reaching the learning criteria following session 10. Besides, for trace-conditioned animals, the Syn expression in IN was found significantly up-regulated after session 10 compared with pseudoconditioned ones. Our data suggest that the increase in Syn expression links to synaptic plasticity changes in the cerebellar IN and provides a histological substrate in the IN relating to TEBC training. The changing trend of Syn immunoreactivity in the IN is associated with CR percentage.

Neural Responses to Electrical Stimulation of the Cochlea in Guinea Pigs

1994 ◽  
Vol 21 (4) ◽  
pp. 201-208
Author(s):  
Jun-Ichi Matsushima ◽  
Chihiro Harada ◽  
Noboru Sakai ◽  
Tohru Ifukube ◽  
Makoto Takahashi
Keyword(s):  
Electrical Stimulation ◽  
Guinea Pigs ◽  
Neural Responses ◽  
Stimulation Of

Efferent-mediated protection from acoustic overexposure: relation to slow effects of olivocochlear stimulation

1995 ◽  
Vol 73 (2) ◽  
pp. 506-514 ◽  
Author(s):  
E. R. Reiter ◽  
M. C. Liberman
Keyword(s):  
Electrical Stimulation ◽  
Inner Ear ◽  
Guinea Pigs ◽  
Threshold Shift ◽  
Exposure Condition ◽  
Protective Effects ◽  
Acoustic Overstimulation ◽  
Different Levels ◽  
Stimulation Of

1. The present study attempts to resolve discrepancies in the reported role of olivocochlear (OC) efferent activation in protecting the inner ear from acoustic overstimulation: in previous studies, activating the OC system in guinea pigs reduced the threshold shift caused by 1 min monaural exposure to a 10-kHz tone; whereas unilateral OC activation in cats had no effect on threshold shifts following binaural exposure to a 10 min 6-kHz tone. 2. In this study, anesthetized and curarized guinea pigs were exposed either monaurally or binaurally to tones of different duration (1-5 min), frequency (6 to 10 kHz) and intensity (105-118 dB SPL). For each exposure condition, threshold shifts were compared among ears with different levels of OC activation: in some cases, the OC bundle (OCB) was electrically stimulated during (and/or before) the acoustic overexposure; in others, the OCB was cut before the exposure; in control cases, the OCB was neither cut nor electrically stimulated. 3. Electrical stimulation of the OCB delivered simultaneously with acoustic overstimulation produced significant reductions in threshold shift only for acoustic exposures at higher frequencies (8 and 10 kHz) and shorter durations (1 and 2 min). The protective effects on 1-min exposures could be extinguished by prior stimulation of the OCB, i.e., if the OC stimulation was turned on 4 min before the acoustic overexposure.(ABSTRACT TRUNCATED AT 250 WORDS)

Electrical stimulation of the amygdala as a conditioned stimulus in a bait-shyness paradigm

Science ◽  
1978 ◽  
Vol 201 (4355) ◽  
pp. 536-538 ◽  
Author(s):  
A. Phillips ◽  
F. LePiane
Keyword(s):  
Electrical Stimulation ◽  
Conditioned Stimulus ◽  
Stimulation Of

scholarly journals Associative Plasticity in the Medial Auditory Thalamus and Cerebellar Interpositus Nucleus during Eyeblink Conditioning

2010 ◽  
Vol 30 (26) ◽  
pp. 8787-8796 ◽  
Author(s):  
H. E. Halverson ◽  
I. Lee ◽  
J. H. Freeman
Keyword(s):  
Eyeblink Conditioning ◽  
Interpositus Nucleus ◽  
Auditory Thalamus ◽  
Cerebellar Interpositus Nucleus
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