scholarly journals HLA antigens in colorectal tumours — low expression of HLA class I antigens in mucinous colorectal carcinomas

1987 ◽  
Vol 55 (2) ◽  
pp. 125-130 ◽  
Author(s):  
HF van den Ingh ◽  
DJ Ruiter ◽  
G Griffioen ◽  
GNP van Muijen ◽  
S Ferrone
Keyword(s):  
Hla Antigens ◽  
Hla Class I ◽  
Class I ◽  
Colorectal Carcinomas ◽  
Hla Class I Antigens ◽  
Low Expression ◽  
Colorectal Tumours

MEGAKARYOCYTIC ORIGIN OF PLATELET HLA CLASS I ANTIGEN

1987 ◽  
Author(s):  
N Kieffer ◽  
M Titeux ◽  
A Henri ◽  
J Breton-Gorius ◽  
W Vainchenker
Keyword(s):  
Hla Antigens ◽  
Hla Class I ◽  
Human Platelets ◽  
Class I ◽  
Double Labeling ◽  
Hla Antigen ◽  
Platelet Surface ◽  
Hla Class I Antigens ◽  
Hla Class I Antigen

The existence of HLA class I antigens on human platelets is well established. However, several authors have suggested that platelet HLA antigens are not integral membrane components but are acquired from soluble plasma sources and adsorbed to the platelet surface.In the present study, we used the monoclonal antibody W6/32, directed against a monomorphic epitope of the HLA class I antigen for the immunochemical characterization of platelet HLA. Immunoprecipitation experiments, performed after in vitro metabolic radiolabeling of human platelets revealed a band of molecular weight 44,000 identical to that precipitated from metabolic labeled U937 or HEL cells. When the same antibody was tested by indirected immunofluorescence in a double labeling technique on in vitro cultures of human megakaryocytes, performed in the absence of human serum in the culture medium, megakaryocytes identified by an anti-vWF MoAb revealed a membrane staining with W6/32 identical to that observed on other bone marrow cells, e.g. macrophages. Our results provide evidence that platelet HLA has a megaka-ryocytic origin and that residual biosynthesis of HLA antigen does still occur in circulating platelets. However, our results do not exclude the ability of human platelets to adsord circulating HLA class I antigen from plasma.

scholarly journals Studying HLA class I polymorphism in brain tumour patients

2012 ◽  
Vol 9 (3) ◽  
pp. 481-490
Author(s):  
Baghdad Science Journal
Keyword(s):  
Brain Tumour ◽  
Brain Tumours ◽  
Hla Antigens ◽  
Hla Class I ◽  
Class I ◽  
Tumour Control ◽  
Hla Class I Antigens ◽  
Age Range ◽  
Shed Light ◽  
Apparently Healthy

The present study aimed at shed light on the association between HLA-class I antigens (A, B and Cw) and brain tumours (meningioma and glioma) in the basis of their individual frequencies or two-locus association A total of 52 brain tumour patients were enrolled in this study, with an age range of 7-68 years. The patients were divided into two clinical groups; meningioma (20 cases) and glioma (22 cases), while the remaining 10 cases represented other types of brain tumour. Control samples included 47 Iraqi Arab apparently healthy blood volunteers, with an age range of 15-50 year. Three HLA antigens showed a significant increased frequency in total patients as compared to controls. They were B13 (34.6 vs. 6.5%), B40 (15.4 vs. 2.2%) and Cw3 (15.4 vs. 2.2%). In contrast, B5 was significantly decreased (15.4 vs. 34.8%). In meningioma patients, only B13 was significantly increased (35.0 vs. 6.5%), while in glioma patients, B13 (36.4 vs. 6.5%) and Cw5 (36.4 vs. 2.2%) were significantly increased. Variations between patients and controls have been also encountered for the observed and expected HLA-two locus associations (B13-Cw3, B13-Cw5 and B40-Cw5).

Interaction Between HLA Class I Antigens and γ-Endorphin

1984 ◽  
pp. 643-643
Author(s):  
F. H. J. Claas ◽  
R. Castelli-Visser ◽  
B. M. de Jongh ◽  
J. J. van Rood ◽  
W. M. A. Verhoeven ◽  
...  
Keyword(s):  
Hla Class I ◽  
Class I ◽  
Hla Class I Antigens

The interaction between γ-type endorphins and HLA class I antigens

1986 ◽  
Vol 15 (4) ◽  
pp. 347-356 ◽  
Author(s):  
Frans H.J. Claas ◽  
Jan M. van Ree ◽  
Wim M.A. Verhoeven ◽  
Jan J. van der Poel ◽  
Willem Verduyn ◽  
...  
Keyword(s):  
Hla Class I ◽  
Class I ◽  
Hla Class I Antigens

Hla Class I Antigens in Human Tumors

1995 ◽  
pp. 155-195 ◽  
Author(s):  
Federico Garrido ◽  
Teresa Cabrera ◽  
Miguel Angel Lopez-Nevot ◽  
Francisco Ruiz-Cabello
Keyword(s):  
Hla Class I ◽  
Human Tumors ◽  
Class I ◽  
Hla Class I Antigens

Prevention of xenograft rejection by masking donor HLA class I antigens

Science ◽  
1991 ◽  
Vol 252 (5013) ◽  
pp. 1700-1702 ◽  
Author(s):  
D. Faustman ◽  
C. Coe
Keyword(s):  
Hla Class I ◽  
Class I ◽  
Xenograft Rejection ◽  
Hla Class I Antigens
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