scholarly journals High-dose folinic acid and 5-fluorouracil bolus and continuous infusion in advanced colorectal cancer: poor response rate in unselected patients

1995 ◽  
Vol 72 (3) ◽  
pp. 774-776 ◽  
Author(s):  
CL Hanna ◽  
FE McKinna ◽  
LB Williams ◽  
D Morrey ◽  
M Adams ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Continuous Infusion ◽  
Folinic Acid ◽  
Advanced Colorectal Cancer ◽  
Response Rate ◽  
Poor Response ◽  
High Dose

scholarly journals High dose folinic acid and 5-fluorouracil bolus and continuous infusion for patients with advanced colorectal cancer

Cancer ◽  
1995 ◽  
Vol 76 (7) ◽  
pp. 1126-1131 ◽  
Author(s):  
Yves H. Bécouarn ◽  
René C. Brunet ◽  
Marie-Laurence P. Rouhier ◽  
Emmanuel J. Bussières ◽  
Antoine R. Avril ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Continuous Infusion ◽  
Folinic Acid ◽  
Advanced Colorectal Cancer ◽  
High Dose

High-dose folinic acid and 5-fluorouracil bolus and continuous infusion in advanced colorectal cancer

1988 ◽  
Vol 24 (9) ◽  
pp. 1499-1503 ◽  
Author(s):  
Aimery de Gramont ◽  
Marcel Krulik ◽  
Jean Cady ◽  
Bertrand Lagadec ◽  
Jean-Eric Maisani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Continuous Infusion ◽  
Folinic Acid ◽  
Advanced Colorectal Cancer ◽  
High Dose

High-dose continuous infusion folinic acid and bolus 5-fluorouracil in patients with advanced colorectal cancer: a phase II study.

1986 ◽  
Vol 4 (7) ◽  
pp. 1058-1061 ◽  
Author(s):  
M Bertrand ◽  
J H Doroshow ◽  
P Multhauf ◽  
D W Blayney ◽  
B I Carr ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Ionizing Radiation ◽  
Continuous Infusion ◽  
Folinic Acid ◽  
Phase Ii ◽  
Initial Dose ◽  
Advanced Colorectal Cancer ◽  
Phase Ii Study ◽  
High Dose ◽  
Previously Treated

Encouraging results have recently been reported for studies using folinic acid in combination with 5-fluorouracil (5-FU) in the treatment of patients with gastrointestinal (GI) malignancies. Thirty-six patients with advanced colorectal cancer with unequivocal evidence of progression while treated with fluoropyrimidines were treated with a six-day continuous infusion of 500 mg/m2/d of folinic acid initiated 24 hours before a five-day course of 5-FU administered as an intravenous (IV) bolus of 370 mg/m2/d. An initial dose of 250 mg/m2/d of 5-FU was used in patients previously treated with ionizing radiation and/or a nitrosourea. Three objective partial responses were observed. The overall median duration of survival was 8.1 months. Toxicity was acceptable and not in excess of that expected for 5-FU alone.

Randomized Trial of 5-Fluorouracil and High-Dose Folinic Acid With or Without Alpha-2B Interferon in Advanced Colorectal Cancer

1996 ◽  
Vol 19 (3) ◽  
pp. 301-304 ◽  
Author(s):  
Francesco Recchia ◽  
Antonio Nuzzo ◽  
Angelo Lalli ◽  
Marco Lombardo ◽  
Liberato Di Lullo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Randomized Trial ◽  
Folinic Acid ◽  
Advanced Colorectal Cancer ◽  
High Dose

scholarly journals A phase II trial of weekly high dose continuous infusion 5-fluorouracil plus oral leucovorin in patients with advanced colorectal cancer

Cancer ◽  
1995 ◽  
Vol 76 (4) ◽  
pp. 559-563 ◽  
Author(s):  
Enrique Aranda ◽  
Andrés Cervantes ◽  
Javier Dorta ◽  
Esperanza Blanco ◽  
Carlos Fernández-Martos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Continuous Infusion ◽  
Phase Ii ◽  
Advanced Colorectal Cancer ◽  
Phase Ii Trial ◽  
High Dose
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