scholarly journals From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer

Cell Research ◽  
2011 ◽  
Vol 21 (2) ◽  
pp. 245-257 ◽  
Author(s):  
Benjamin Tiede ◽  
Yibin Kang
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Mammary Stem Cells ◽  
Mammary Stem

Mammary Stem Cells and Breast Cancer—Role of Notch Signalling

2007 ◽  
Vol 3 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Gillian Farnie ◽  
Robert B. Clarke
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Notch Signalling ◽  
Mammary Stem Cells ◽  
Mammary Stem

Mammary stem cells: the root of breast cancer?

2004 ◽  
Vol 7 (9) ◽  
Author(s):  
H. A. Coppock ◽  
R. B. Clarke
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Mammary Gland ◽  
Cancer Prevention ◽  
Breast Cancer Prevention ◽  
Differentiated Cells ◽  
Mammary Stem ◽  
Tissue Specific Stem Cells ◽  
Prevention And Therapy

Tissue-specific stem cells play a key role in organ homoeostasis. They are relatively well characterized in systems which undergo constant proliferation and production of differentiated cells, including the haemopoietic system, skin and intestine. However, little is known about the role and regulation of stem cells in the mammary gland. This review briefly summarizes the current understanding of the role of breast-specific stem cells in normal and cancerous tissues, and how this may identify new targets for breast cancer prevention and therapy.

Abstract 5011: Molecular alterations in mammary stem cells in response to pregnancy or short-term estradiol treatment leads to the reduced risk of breast cancer.

2013 ◽  
Author(s):  
Sushmita B. Nandy ◽  
Arunkumar Arumugam ◽  
Jacqueline Parada ◽  
Rebecca Lopez ◽  
Thiyagarajan Boopalan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Mammary Stem Cells ◽  
Short Term ◽  
Estradiol Treatment ◽  
Molecular Alterations ◽  
Mammary Stem ◽  
Reduced Risk

scholarly journals Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer

2016 ◽  
Vol 156 (2) ◽  
pp. 211-226 ◽  
Author(s):  
Maria Cristina Rangel ◽  
Daniel Bertolette ◽  
Nadia P. Castro ◽  
Malgorzata Klauzinska ◽  
Frank Cuttitta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Signaling Pathways ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Mammary Stem Cells ◽  
Developmental Signaling ◽  
Mammary Stem

scholarly journals The Controversial Clinicobiological Role of Breast Cancer Stem Cells

2008 ◽  
Vol 2008 ◽  
pp. 1-12 ◽  
Author(s):  
Claudia Casarsa ◽  
Saro Oriana ◽  
Danila Coradini
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Experimental Evidence ◽  
Clinical Importance ◽  
Breast Cancer Stem Cells ◽  
Real Nature ◽  
Mammary Stem ◽  
Clinical Potential

Breast cancer remains a leading cause of morbidity and mortality in women mainly because of the propensity of primary breast tumors to metastasize. Growing experimental evidence suggests that cancer stem cells (CSCs) may contribute to tumor progression and metastasis spread. However, despite the tremendous clinical potential of such cells and their possible therapeutic management, the real nature of CSCs remains to be elucidated. Starting from what is currently known about normal mammary stem/progenitor cells, to better define the cell that originates a tumor or is responsible for metastatic spread, this review will discuss experimental evidence of breast cancer stem cells and speculate about the clinical importance and implications of their evaluation.

scholarly journals Functional characterization of mammary stem cells in development and breast cancer

2003 ◽  
Vol 5 (S1) ◽  
Author(s):  
JM Rosen ◽  
BE Welm ◽  
SB Tepera ◽  
F Behbod ◽  
SL Grimm ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Functional Characterization ◽  
Mammary Stem Cells ◽  
Mammary Stem
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