scholarly journals Giant retinal pigment epithelial rip in polypoidal choroidal vasculopathy with vitreous haemorrhage after pars plana vitrectomy

Eye ◽  
2009 ◽  
Vol 24 (5) ◽  
pp. 940-941
Author(s):  
K-J Chen ◽  
K-K Lin ◽  
T-L Chen
Keyword(s):  
Polypoidal Choroidal Vasculopathy ◽  
Pars Plana Vitrectomy ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Vitreous Haemorrhage ◽  
Pigment Epithelial ◽  
Pars Plana ◽  
Choroidal Vasculopathy

Cytoprotective effect of crocin and trans-resveratrol on photodamaged primary human retinal pigment epithelial cells

2019 ◽  
pp. 112067211989596
Author(s):  
Stefan Kassumeh ◽  
Christian M Wertheimer ◽  
Andreas Ohlmann ◽  
Siegfried G Priglinger ◽  
Armin Wolf
Keyword(s):  
Epithelial Cells ◽  
Pars Plana Vitrectomy ◽  
Retinal Pigment Epithelial ◽  
Light Exposure ◽  
Retinal Pigment ◽  
Retinal Pigment Epithelial Cells ◽  
Enzyme Linked Immunosorbent Assay ◽  
Pigment Epithelial ◽  
Pars Plana ◽  
Pigment Epithelial Cells

Purpose: Light-induced damage to retinal pigment epithelium during pars plana vitrectomy remains a hot topic in ophthalmology. Improvements in technology led to a change of light sources, selective filters, and shorter light exposure time. Currently, there is no satisfying solution to the problem. The aim of the study was to investigate the cytoprotective effects of crocin and resveratrol on light-induced damage to primary human retinal pigment epithelial cells in vitro. Methods: Primary human retinal pigment epithelial cells were exposed to light analogous to the illumination during pars plana vitrectomy. To evaluate the cytoprotective effects and potential toxicity of resveratrol and crocin, human retinal pigment epithelial cells were incubated with varying concentrations of both before 3-[4,5-dimethylthiazol-2-yl] tetrazolium bromide (MTT) viability assay. Furthermore, glutathione levels were measured to investigate synergistic antioxidant potential. Apoptosis of human retinal pigment epithelial cells was determined by a nucleosome detection enzyme-linked immunosorbent assay. Results: Crocin and resveratrol improved cell viability in photodamaged human retinal pigment epithelial cells significantly from 40.65 ± 21.99% in illuminated human retinal pigment epithelial cells and reached a peak viability of 85.64 ± 11.37% in crocin and resveratrol pretreated cells (for all: p < 0.001). In line, the combination of the supplements increased glutathione levels significantly from 39.35 ± 21.96% to 80.74 ± 10.32% ( p = 0.017). No toxic effects were detected ( p > 0.99). However, no change in apoptosis rates could be observed following pretreatment with crocin and resveratrol ( p > 0.99). Conclusion: Crocin and trans-resveratrol revealed cytoprotective effects on human retinal pigment epithelial cells supporting both supplement’s development as potential perioperative treatments in light-induced retinal pigment epithelial damage.

RETINAL PIGMENT EPITHELIAL TEAR IN POLYPOIDAL CHOROIDAL VASCULOPATHY

Retina ◽  
2007 ◽  
Vol 27 (7) ◽  
pp. 832-838 ◽  
Author(s):  
AKITAKA TSUJIKAWA ◽  
YASUHIKO HIRAMI ◽  
HIDEO NAKANISHI ◽  
YUMIKO OJIMA ◽  
HIROKO AIKAWA ◽  
...  
Keyword(s):  
Polypoidal Choroidal Vasculopathy ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Pigment Epithelial ◽  
Retinal Pigment Epithelial Tear ◽  
Choroidal Vasculopathy

scholarly journals Polypoidal Choroidal Vasculopathy

2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Sana Nadeem
Keyword(s):  
Polypoidal Choroidal Vasculopathy ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Pigment Epithelial Detachment ◽  
Choroidal Neovascular Membrane ◽  
Hard Exudates ◽  
Pigment Epithelial ◽  
Age Related ◽  
Choroidal Vasculopathy

A 76-year-old, hypertensive lady, presented with a three year history of gradual decrease in vision in her right eye. Examination revealed a large, bullous, serous pigment epithelial detachment (PED) of right fovea, a choroidal neovascular membrane, clusters of hard exudates, drusen and surrounding, multifocal, small PEDs. The left eye showed a series of small PEDs mostly on the inferior macula, pigmentary disturbance of the retinal pigment epithelium and scant hard exudates. A diagnosis of Polypoidal choroidal vasculopathy was made. We decided to treat her with intravitreal Bevacizumab injections in her right eye. At 18 months of follow up, her PEDs had resolved and visual acuity had improved from 6/60 OD to 6/36. Key Words:  Polypoidal Choroidal Vasculopathy, Age Related Macular Degeneration, Pigment Epithelial Detachment, Choroidal Neovascular Membrane.

Retinal pigment epithelial atrophy after anti-vascular endothelial growth factor therapy for polypoidal choroidal vasculopathy

2020 ◽  
Vol 104 (10) ◽  
pp. 1443-1447 ◽  
Author(s):  
Han Joo Cho ◽  
Kunhae Kim ◽  
Soo Hyun Lim ◽  
Dong Hyun Kang ◽  
Jong Woo Kim
Keyword(s):  
Choroidal Thickness ◽  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Vascular Endothelial ◽  
Pigment Epithelial ◽  
Anti Vegf ◽  
Rpe Atrophy ◽  
The Mean ◽  
Endothelial Growth Factor ◽  
Choroidal Vasculopathy

Background/aimsTo describe the risk factors for the development of retinal pigment epithelial (RPE) atrophy following intravitreal anti-vascular endothelial growth factor (VEGF) injection treatment for polypoidal choroidal vasculopathy (PCV).MethodsWe retrospectively included 162 eyes of 162 treatment-naïve patients with PCV in this study. All patients were treated with an initial series of three monthly loading doses of anti-VEGF injections, followed by further injections as required. Baseline ocular characteristics and lesion features were assessed using fluorescein angiography, indocyanine green angiography and spectral domain optical coherence tomography, to determine and evaluate the potential risk factors for RPE atrophy through 2 years of follow-up.ResultsRPE atrophy had developed in 17 of 162 eyes (10.5%) after 2 years of anti-VEGF treatment. Nine cases (53.0%) of RPE atrophy occurred at branching vascular networks, and eight (47.0%) developed at locations with polyp or polyp-associated pigment epithelial detachment. Among the baseline characteristics, the mean subfoveal choroidal thickness was significantly thinner (192±98 vs 288±152; p=0.009) and presence of subretinal drusenoid deposits was significantly more frequent in eyes with RPE atrophy (11.8% vs 2.1%; p=0.028). Using multiple logistic regression analysis, the mean subfoveal choroidal thickness (OR 0.975; 95% CI 0.929 to 1.324; p=0.002) was identified as a significant risk factor for the development of RPE atrophy.ConclusionsApproximately one-tenth of the patients with PCV developed RPE atrophy during the 24 months after intravitreal anti-VEGF injections. Subfoveal choroidal thinning at baseline is associated with increased risk of post-treatment RPE atrophy.

scholarly journals Idiopathic polypoidal choroidal vasculopathy

2012 ◽  
Vol 69 (1) ◽  
pp. 85-89
Author(s):  
Sonja Cekic ◽  
Dijana Risimic ◽  
Ivan Jovanovic ◽  
Jasmina Djordjevic-Jocic
Keyword(s):  
Retinal Pigment Epithelium ◽  
Polypoidal Choroidal Vasculopathy ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Anterior Segment ◽  
Age Related Macular Degeneration ◽  
Slit Lamp ◽  
Pigment Epithelial ◽  
Choroidal Vasculopathy ◽  
Slit Lamp Biomicroscopy

Background. Idiopathic polypoidal choroidal vasculopathy (IPCV) is uncommon condition. It is considered to be a variant of neovascular age-related macular degeneration, but it can be also found in younger patients. Case report. We presented a case of otherwise healthy, 36-year-old women, with sudden unilateral visual impairment in the left eye and metamorphosia. Slit lamp biomicroscopy examination of the eye anterior segment was normal. Intraocular pressure determined by aplanation tonometry was 16 mmHg in both eyes. Indirect slit lamp biomicroscopy examination showed signs of serosanquinous detachments of the retinal pigment epithelium. Fluorescein angiography showed a subretinal vessel network through the pigment epithelial atrophy with hyperfluorescence in superior part of serohemorrhagic pigment epithelial detachment and the inferior hypofluorescence, caused by hemorrhage. Optical coherence tomography proved detachment of the retinal pigment epithelium. Conclusion. In patients with IPCV a mild, natural course with spontaneous resorption of exudations and hemorrhage and improvement in visual acuity can be observed. There is no approved treatment at present.

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