Toll‐like receptor 2 siRNA suppresses corneal inflammation and attenuates Aspergillus fumigatus keratitis in rats

2011 ◽  
Vol 90 (3) ◽  
pp. 352-357 ◽  
Author(s):  
Hui Guo ◽  
Jianlu Gao ◽  
Xinyi Wu
Keyword(s):  
Aspergillus Fumigatus ◽  
Toll Like Receptor ◽  
Corneal Inflammation ◽  
Toll Like Receptor 2

Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2

2007 ◽  
Vol 9 (2) ◽  
pp. 368-381 ◽  
Author(s):  
Kathrin Luther ◽  
Antonella Torosantucci ◽  
Axel A. Brakhage ◽  
Jürgen Heesemann ◽  
Frank Ebel
Keyword(s):  
Aspergillus Fumigatus ◽  
Toll Like Receptor ◽  
Beta Glucan ◽  
Murine Macrophages ◽  
Toll Like Receptor 2

scholarly journals Modulation of Toll-Like Receptor 2 (TLR2) and TLR4 Responses by Aspergillus fumigatus

2009 ◽  
Vol 77 (5) ◽  
pp. 2184-2192 ◽  
Author(s):  
Louis Y. A. Chai ◽  
Bart Jan Kullberg ◽  
Alieke G. Vonk ◽  
Adilia Warris ◽  
Alessandra Cambi ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Mononuclear Cells ◽  
Receptor Expression ◽  
Toll Like Receptor ◽  
Mrna Transcription ◽  
Human Mononuclear Cells ◽  
Tlr4 Mrna ◽  
Proinflammatory Responses ◽  
Surface Receptor ◽  
Toll Like Receptor 2

ABSTRACT Toll-like receptor (TLR)-based signaling pathways in the host may be modulated by pathogens during the course of infection. We describe a novel immunomodulatory mechanism in which Aspergillus fumigatus conidia induce attenuation of TLR2- and TLR4-mediated interleukin (IL)-6 and IL-1β proinflammatory responses in human mononuclear cells with suppression of IL-1β mRNA transcription. Background TLR2 and TLR4 mRNA transcription was not influenced. A. fumigatus conidia induced TLR2 internalization and uptake into the phagosome with a resultant decrease in surface receptor expression. A. fumigatus hyphae, on the other hand, selectively downregulated the TLR4-mediated response. These novel immunosuppressive effects may facilitate the invasiveness of A. fumigatus.

scholarly journals Toll-like receptor 2 and dectin-1 function as promising biomarker for Aspergillus fumigatus infection

2017 ◽  
Vol 14 (4) ◽  
pp. 3836-3840
Author(s):  
Peng-Peng Zhang ◽  
Xiao-Feng Xin ◽  
Xiao-Yong Xu ◽  
Li-Ping Fang ◽  
Jie Wu ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

Toll-like receptor 2 signaling is important for fas ligand on NKT cells, may contribute to liver injury induced by Salmonella infection

2001 ◽  
Vol 120 (5) ◽  
pp. A357-A357
Author(s):  
H SHIMIZU ◽  
Y FUKUDA ◽  
I NAKANO ◽  
Y KATANO ◽  
K NAGANO ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fas Ligand ◽  
Nkt Cells ◽  
Toll Like Receptor ◽  
Salmonella Infection ◽  
Toll Like Receptor 2
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