scholarly journals Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne

2013 ◽  
Vol 133 (9) ◽  
pp. 2152-2160 ◽  
Author(s):  
Sorel Fitz-Gibbon ◽  
Shuta Tomida ◽  
Bor-Han Chiu ◽  
Lin Nguyen ◽  
Christine Du ◽  
...  
Keyword(s):  
Human Skin ◽  
Propionibacterium Acnes ◽  
Skin Microbiome

scholarly journals Cutibacterium acnesantibiotic production shapes niche competition in the human skin microbiome

2019 ◽  
Author(s):  
Jan Claesen ◽  
Jennifer B Spagnolo ◽  
Stephany Flores Ramos ◽  
Kenji L Kurita ◽  
Allyson L Byrd ◽  
...  
Keyword(s):  
Human Skin ◽  
Propionibacterium Acnes ◽  
Biosynthetic Gene Cluster ◽  
Hair Follicles ◽  
Skin Microbiome ◽  
Experimental Characterization ◽  
Cutibacterium Acnes ◽  
Niche Competition ◽  
Individual Human

AbstractThe composition of the skin microbiome varies widely among individuals sampled at the same body site. A key question is which molecular factors determine strain-level variability within sub-ecosystems of the skin. We used a genomics-guided approach to identify an antibacterial biosynthetic gene cluster inCutibacterium acnes(formerlyPropionibacterium acnes) that is widely distributed across individuals and skin sites. Experimental characterization of this cluster enabled the identification of a new thiopeptide antibiotic, cutimycin. Analysis of individual human skin hair follicles showed that cutimycin is an important factor regulating colonization resistance againstStaphylococcusspecies.One Sentence SummaryCutimycin, a thiopeptide antibiotic produced by a widespread skin commensal, reducesStaphylococcuscolonization of human follicles.

scholarly journals SkinBug: an artificial intelligence approach to predict human skin microbiome-mediated metabolism of biotics and xenobiotics

iScience ◽  
2021 ◽  
Vol 24 (1) ◽  
pp. 101925
Author(s):  
Shubham K. Jaiswal ◽  
Shitij Manojkumar Agarwal ◽  
Parikshit Thodum ◽  
Vineet K. Sharma
Keyword(s):  
Artificial Intelligence ◽  
Human Skin ◽  
Skin Microbiome ◽  
Intelligence Approach ◽  
Artificial Intelligence Approach

scholarly journals Complete Genome Sequence of Malassezia restricta CBS 7877, an Opportunist Pathogen Involved in Dandruff and Seborrheic Dermatitis

2019 ◽  
Vol 8 (6) ◽  
Author(s):  
Stanislas C. Morand ◽  
Morgane Bertignac ◽  
Agnes Iltis ◽  
Iris C. R. M. Kolder ◽  
Walter Pirovano ◽  
...  
Keyword(s):  
Human Skin ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Seborrheic Dermatitis ◽  
Skin Microbiome ◽  
Basidiomycetous Yeasts ◽  
Content Type ◽  
Opportunist Pathogen ◽  
Malassezia Restricta

Malassezia restricta, one of the predominant basidiomycetous yeasts present on human skin, is involved in scalp disorders. Here, we report the complete genome sequence of the lipophilic Malassezia restricta CBS 7877 strain, which will facilitate the study of the mechanisms underlying its commensal and pathogenic roles within the skin microbiome.

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