Neonatal hyperglycemia and diminished long-term growth in very low birth weight preterm infants

Abstract Background Antenatal corticosteroids (ACS) treatment is critical to support survival and lung maturation in preterm infants, however, its effect on feeding and growth is unclear. Prior preterm delivery, it remains uncertain whether ACS treatment should be continued if possible (repeated course ACS), until a certain gestational age is reached. We hypothesized that the association of single-course ACS with feeding competence and postnatal growth outcomes might be different from that of repeated course ACS in very-low-birth-weight preterm infants. Methods A multicenter retrospective cohort study was conducted in very-low-birth-weight preterm infants born at 23–37 weeks’ gestation in South China from 2011 to 2014. Data on growth, nutritional and clinical outcomes were collected. Repeated course ACS was defined in this study as two or more courses ACS (more than single-course). Infants were stratified by gestational age (GA), including GA < 28 weeks, 28 weeks ≤ GA < 32 weeks and 32 weeks ≤ GA < 37 weeks. Multiple linear regression and multilevel model were applied to analyze the association of ACS with feeding and growth outcomes. Results A total of 841 infants were recruited. The results, just in very-low-birth-weight preterm infants born at 28–32 weeks’ gestation, showed both single and repeated course of ACS regimens had shorter intubated ventilation time compared to non-ACS regimen. Single-course ACS promoted the earlier application of amino acid and enteral nutrition, and higher rate of weight increase (15.71; 95%CI 5.54–25.88) than non-ACS after adjusting for potential confounding factors. No associations of repeated course ACS with feeding, mean weight and weight increase rate were observed. Conclusions Single-course ACS was positively related to feeding and growth outcomes in very-low-birth-weight preterm infants born at 28–32 weeks’ gestation. However, the similar phenomenon was not observed in the repeated course of ACS regimen.

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A pioneering study: oral clarithromycin treatment for feeding intolerance in very low birth weight preterm infants

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767058.2017.1304908 ◽

2017 ◽

Vol 31 (8) ◽

pp. 988-992

Author(s):

Selim Sancak ◽

Tugba Gursoy ◽

Abdulhamit Tuten ◽

Didem Arman ◽

Guner Karatekin ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Preterm Infants ◽

Very Low Birth Weight ◽

Feeding Intolerance

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Late-Onset Sepsis in Very Low Birth Weight Preterm Infants: 7 years’ Experience at a Tertiary Hospital in China

Pediatrics & Neonatology ◽

10.1016/j.pedneo.2021.05.011 ◽

2021 ◽

Author(s):

Liya Ma ◽

Qiongling Peng ◽

Wei Wang ◽

Yi Yang ◽

You Chen ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Preterm Infants ◽

Very Low Birth Weight ◽

Late Onset ◽

Tertiary Hospital ◽

Late Onset Sepsis

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Very Low Birth Weight Outcomes

PEDIATRICS ◽

10.1542/peds.89.2.357a ◽

1992 ◽

Vol 89 (2) ◽

pp. 357-357

Author(s):

HELEN HARRISON

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Neonatal Intensive Care ◽

Very Low Birth Weight ◽

Meta Analysis ◽

Low Birth Weight Infants ◽

Randomized Controlled Clinical Trials ◽

Weight Outcomes ◽

Term Evaluation

To the Editor.— The authors of the National Institute of Child Health and Human Development report on neonatal care1 found "important" variations among neonatal intensive care units in philosophies of treatment, methods of treatment, and short-term outcomes. In a recent meta-analysis of follow-up studies,2 researchers document a similarly haphazard approach to the long-term evaluation of very low birth weight survivors. Until randomized controlled clinical trials validate the safety and efficacy of neonatal therapies, and until long-term outcomes are assessed accurately, the treatment of very low birth weight infants should be declared experimental.

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