scholarly journals Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven cases

2011 ◽  
Vol 24 (11) ◽  
pp. 1421-1432 ◽  
Author(s):  
Haipeng Shao ◽  
Liqiang Xi ◽  
Mark Raffeld ◽  
Andrew L Feldman ◽  
Rhett P Ketterling ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Small Lymphocytic Lymphoma ◽  
Cell Sarcoma ◽  
Dendritic Cell Sarcoma

Transformation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma to Interdigitating Dendritic Cell Sarcoma

2009 ◽  
Vol 132 (6) ◽  
pp. 928-939 ◽  
Author(s):  
Cory R. Fraser ◽  
Wei Wang ◽  
Mario Gomez ◽  
Taotao Zhang ◽  
Susan Mathew ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Small Lymphocytic Lymphoma ◽  
Cell Sarcoma ◽  
Dendritic Cell Sarcoma ◽  
Interdigitating Dendritic Cell Sarcoma

Interdigitating dendritic cell sarcoma with immunoglobin rearrangement arrose in a chronic lymphocytic leukemia patient

2015 ◽  
Vol 15 ◽  
pp. S67
Author(s):  
Kohno Kentaro ◽  
Tanaka Risa ◽  
Shiratsuchi Hideki ◽  
Kadowaki Masanori ◽  
Takase Ken ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Chronic Lymphocytic Leukemia ◽  
Chronic Lymphocytic Leukemia Patient ◽  
Lymphocytic Leukemia ◽  
Cell Sarcoma ◽  
Leukemia Patient ◽  
Dendritic Cell Sarcoma ◽  
Interdigitating Dendritic Cell Sarcoma

Concurrent cutaneous localization of Langerhans cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma in a patient with a history of chronic lymphocytic leukemia/small lymphocytic lymphoma

2019 ◽  
Vol 47 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Alexandra Papoudou‐Bai ◽  
Amalia Vassou ◽  
Leonidas Marinos ◽  
Konstantina Papathanasiou ◽  
Eleni Kapsali ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Langerhans Cell ◽  
Lymphocytic Leukemia ◽  
Small Lymphocytic Lymphoma ◽  
Cell Sarcoma ◽  
Langerhans Cell Sarcoma ◽  
Cutaneous Localization ◽  
History Of

The Impacts of Zanubrutinib on Immune Cells in Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

2019 ◽  
Author(s):  
Yi-xin Zou ◽  
Hua-Yuan Zhu ◽  
Xiao-tong Li ◽  
Yi Xia ◽  
Kou-rong Miao ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Immune Cells ◽  
Lymphocytic Leukemia ◽  
Small Lymphocytic Lymphoma

scholarly journals The pathological features of leukemic cells infiltrating the renal interstitium in chronic lymphocytic leukemia/small lymphocytic lymphoma from a large single Chinese center

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Hui Wang ◽  
Xiaojuan Yu ◽  
Xu Zhang ◽  
Suxia Wang ◽  
Minghui Zhao
Keyword(s):  
Electron Microscopy ◽  
Chronic Lymphocytic Leukemia ◽  
Renal Injury ◽  
Lymphocytic Leukemia ◽  
Leukemic Cells ◽  
Cell Infiltration ◽  
Small Lymphocytic Lymphoma ◽  
Tubulointerstitial Injury ◽  
Renal Interstitium ◽  
Monoclonal Immunoglobulins

Abstract Background Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is rare in Asians, and patients with CLL/SLL seldomly undergo kidney biopsy. The histopathological features and clinical relevance of tubulointerstitial injury in CLL/SLL have not been extensively characterized. Hence, we attempted to describe the clinical characteristics, renal pathology and clinical outcome of a well-characterized population of CLL/SLL patients with CLL cell infiltration in the renal interstitium from a large single center in China. Methods Between January 1st, 2010 and September 31st, 2020, 31946renal biopsies were performed at Peking University First Hospital, and 10 CLL/SLL patients with CLL cell infiltration in the renal interstitium were included. Complete clinical data were collected from these 10 patients, and renal specimens were examined by routine light microscopy, immunofluorescence and electron microscopy. Results The extent of the infiltrating CLL cells in patients with CLL/SLL varied among different patients and ranged from 10 to 90% of kidney parenchyma. Six (60%) of 10 patients presented with an extent of infiltrating CLL cells ≥50%. Interestingly, we found that three patients (3/10, 30%) expressed monoclonal immunoglobulins in the infiltrating CLL cells, and special cytoplasmic crystalline structures were found in two of the three patients by electron microscopy for the first time. Severe renal insufficiency (Scr ≥200 μmol/L) was associated with ≥50% interstitial infiltration of CLL cells in the renal interstitium. Conclusions The current study confirmed that CLL cells infiltrating the renal interstitium can directly secrete monoclonal immunoglobulins, indicating that the interstitial infiltrating CLL cells possibly cause renal injury directly by secreting monoclonal immunoglobulins in situ. This finding may prove a new clue to elucidate the pathogenetic mechanism of renal injury involved with CLL/SLL.

Veterans with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) have a Markedly Increased Rate of Second Malignancy, which is the Most Common Cause of Death

2004 ◽  
Vol 45 (3) ◽  
pp. 507-513 ◽  
Author(s):  
Mouhammed J Kyasa ◽  
Linda Hazlett ◽  
Rudolph S Parrish ◽  
Steven A Schichman ◽  
Clive S Zent
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Cause Of Death ◽  
Lymphocytic Leukemia ◽  
Second Malignancy ◽  
Small Lymphocytic Lymphoma ◽  
Common Cause
Sign in / Sign up

Export Citation Format

Share Document